Siren, L.L.C. Q4 2025 Filing
Filed February 13, 2026
Portfolio Value
$3.4B
Holdings
113
Report Date
Q4 2025
Filing Type
13F-HR
All Holdings (113 positions)
| Stock | Value |
|---|---|
SRRKScholar Rock Holding Corp | $476.8M |
KYMRKymera Therapeutics Inc | $255.7M |
ONCBeOne Medicines AG | $151.9M |
EWTXEdgewise Therapeutics Inc | $112.4M |
RVMDRevolution Medicines Inc | $106.3M |
CNTACentessa Pharmaceuticals PLC | $100.7M |
ARWRArrowhead Pharmaceuticals Inc | $99.6M |
BCAXBicara Therapeutics Inc | $87.8M |
OLMAOlema Pharmaceuticals Inc | $82.5M |
IRONDisc Medicine Inc | $78.5M |
GPCRStructure Therapeutics Inc | $75.0M |
TNGXTango Therapeutics Inc | $72.3M |
RCUSArcus Biosciences Inc | $71.7M |
STOKStoke Therapeutics Inc | $71.3M |
CRNXCrinetics Pharmaceuticals Inc | $70.2M |
DYNDyne Therapeutics Inc | $68.5M |
APLSApellis Pharmaceuticals Inc | $64.8M |
COGTCogent Biosciences Inc | $57.9M |
SEPNSepterna Inc | $55.8M |
TSHATaysha Gene Therapies Inc | $55.7M |
RYTMRhythm Pharmaceuticals Inc | $53.5M |
ASNDAscendis Pharma A/S | $50.3M |
RAPTRAPT Therapeutics Inc | $46.6M |
TBLATaboola.com Ltd | $46.0M |
LXRXLexicon Pharmaceuticals Inc | $44.8M |
ZYMEZymeworks Inc | $44.2M |
SLDBSolid Biosciences Inc | $43.4M |
WVEWAVE Life Sciences Ltd | $41.6M |
XENEXenon Pharmaceuticals Inc | $36.4M |
DBVTDbv Technologies SA | $35.6M |
ERASErasca Inc | $32.6M |
ENGNenGene Holdings Inc | $30.1M |
TRVITrevi Therapeutics Inc | $28.6M |
SYRESpyre Therapeutics Inc | $26.8M |
MLYSMineralys Therapeutics Inc | $25.4M |
DNLIDenali Therapeutics Inc | $23.1M |
RELYRemitly Global Inc | $22.3M |
FULCFulcrum Therapeutics Inc | $22.1M |
RAPPRapport Therapeutics Inc | $21.5M |
SLNSilence Therapeutics PLC | $17.7M |
IHSIHS Holding Limited | $17.6M |
GOSSGossamer Bio Inc | $16.1M |
UPBUpstream Bio Inc | $16.0M |
BCYCBicycle Therapeutics PLC | $14.3M |
MNPRMonopar Therapeutics Inc | $13.9M |
CGEMCullinan Therapeutics Inc | $12.4M |
SIONSionna Therapeutics Inc | $12.3M |
IKTInhibikase Therapeutics Inc | $12.0M |
NBPNovaBridge Biosciences | $11.9M |
AMZNAmazon.com Inc | $11.9M |
NMRANeumora Therapeutics Inc | $11.3M |
BRD1EURMind Medicine (MindMed) Inc | $10.7M |
BNTCBenitec Biopharma Inc | $10.4M |
IVVDInvivyd Inc | $9.9M |
TSMTaiwan Semiconductor Manufacturing Co Ltd | $8.4M |
ORICOric Pharmaceuticals Inc | $8.2M |
MPLTMapLight Therapeutics Inc | $7.9M |
PVLAPalvella Therapeutics Inc | $7.8M |
CRWDCrowdStrike Holdings Inc | $7.7M |
IONQIONQ Inc | $7.6M |
SEERSeer Inc | $7.3M |
MSFTMicrosoft Corp | $7.3M |
PDDPDD Holdings Inc | $7.2M |
LXEOLexeo Therapeutics Inc | $7.2M |
NVDANVIDIA Corp | $7.0M |
CRMSalesforce Inc | $6.9M |
CMPSCompass Pathways PLC | $6.9M |
BLLNBillionToOne Inc | $6.9M |
WKWorkiva Inc | $6.8M |
ZURAZura Bio Ltd | $6.8M |
VTVTvTv Therapeutics Inc | $6.5M |
GOOGLAlphabet Inc | $6.5M |
NBISNebius Group NV | $6.4M |
YB4PSavara Inc | $6.0M |
XFORX4 Pharmaceuticals Inc | $6.0M |
FROGJfrog Ltd | $5.8M |
NOWServiceNow Inc | $5.5M |
TENXTenax Therapeutics Inc | $5.2M |
WHWKWhitehawk Therapeutics Inc | $5.0M |
DTDynatrace Inc | $5.0M |
DDOGDatadog Inc | $5.0M |
ALMSAlumis Inc | $4.9M |
METAMeta Platforms Inc | $4.7M |
PEPGPepGen Inc | $4.6M |
SGMTSagimet Biosciences Inc | $4.3M |
ADBEAdobe Inc | $4.2M |
FHTXFoghorn Therapeutics Inc | $3.9M |
GTLBGitLab Inc | $3.7M |
KLRSKalaris Therapeutics Inc | $3.7M |
N1UANew Oriental Education & Technology Group Inc | $3.4M |
AGENAgenus Inc | $3.3M |
MDLNMedline Inc | $3.1M |
KRROKorro Bio Inc | $2.8M |
CLBTCellebrite DI Ltd | $2.7M |
RANIRani Therapeutics Holdings Inc | $2.7M |
ZSZscaler Inc | $2.7M |
BDTXBlack Diamond Therapeutics Inc | $2.5M |
MNDYmonday.com Ltd | $2.5M |
AVGOBroadcom Inc | $2.4M |
QCOMQualcomm Inc | $2.4M |
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