UPB

Upstream Bio, Inc.
$9.01-0.43 (-4.56%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Shares Held

InfinityB

Total Value

$1.8400015458085336e+221T

% of Float

Infinity%

Price History

$6.07$12.70$19.34$25.97$32.60Oct 24Jul 25Mar 26

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1FMR LLC6,795,985$184.0M0.01%Share
2ORBIMED ADVISORS LLC5,693,589$154.6M3.16%Share
3Decheng Capital LLC3,143,078$85.3M11.48%Share
4NORGES BANK2,882,647$78.0M0.01%Share
5Enavate Sciences GP, LLC2,459,703$66.8M13.18%Share
6VANGUARD GROUP INC2,133,212$57.9M0.00%Share
7UBS Group AG1,805,824$49.0M0.01%Share
8JANUS HENDERSON GROUP PLC1,519,258$41.0M0.02%Share
9BlackRock, Inc.1,376,866$37.0M0.00%Share
10Bain Capital Life Sciences Investors, LLC1,329,544$36.1M2.76%Share
11Omega Fund Management, LLC1,326,293$36.0M12.57%Share
12STATE STREET CORP1,319,226$35.0M0.00%Share
13VR Adviser, LLC1,169,298$31.7M1.57%Share
14BlackRock, Inc.926,116$25.0M0.00%Share
15WELLINGTON MANAGEMENT GROUP LLP894,733$24.0M0.00%Share
16Parkman Healthcare Partners LLC834,559$22.7M2.16%Share
17Pictet Asset Management Holding SA773,148$21.0M0.02%Share
18Integral Health Asset Management, LLC750,000$20.4M1.01%Share
19TCG Crossover Management, LLC743,886$20.2M0.67%Share
20GEODE CAPITAL MANAGEMENT, LLC742,084$20.0M0.00%Share
21Woodline Partners LP760,252$20.0M0.08%Share
22Samsara BioCapital, LLC736,047$20.0M2.06%Share
23Vestal Point Capital, LP720,000$19.5M0.66%Share
24Siren, L.L.C.588,450$16.0M0.48%Share
25BARCLAYS PLC524,499$14.0M0.00%Share
26MILLENNIUM MANAGEMENT LLC517,264$14.0M0.01%Share
27Nantahala Capital Management, LLC494,971$13.4M0.44%Share
28BlackRock, Inc.496,990$13.0M0.00%Share
29FMR LLC475,794$12.0M0.00%Share
30GOLDMAN SACHS GROUP INC333,481$9.0M0.00%Share
31MARSHALL WACE, LLP343,791$9.0M0.01%Share
32GREAT POINT PARTNERS LLC300,000$8.1M2.64%Share
33Alyeska Investment Group, L.P.298,329$8.0M0.02%Share
34JENNISON ASSOCIATES LLC288,847$7.8M0.00%Share
35CHARLES SCHWAB INVESTMENT MANAGEMENT INC284,931$7.0M0.00%Share
36Squadron Capital Management LLC230,650$6.3M2.65%Share
37VANGUARD GROUP INC224,394$6.1M0.00%Share
38BlackRock, Inc.240,260$6.0M0.00%Share
39NORTHERN TRUST CORP230,350$6.0M0.00%Share
40Boxer Capital Management, LLC150,000$4.1M0.89%Share
41FMR LLC162,500$4.0M0.00%Share
42Invesco Ltd.145,555$4.0M0.00%Share
43SummitTX Capital, L.P.116,724$3.2M0.10%Share
44Schonfeld Strategic Advisors LLC115,807$3.1M0.01%Share
45BlackRock, Inc.122,351$3.0M0.00%Share
46DEUTSCHE BANK AG\100,000$2.0M0.00%Share
47ExodusPoint Capital Management, LP75,402$2.0M0.02%Share
48FMR LLC83,898$2.0M0.00%Share
49JPMORGAN CHASE & CO87,233$2.0M0.00%Share
50AMERICAN CENTURY COMPANIES INC87,756$2.0M0.00%Share