Who Owns Septerna, Inc. (SEPN)?Hedge Fund & Institutional Holders

$25.21-1.24 (-4.67%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$1.950441732901341e+217T

% of Float Held

3.7312851926795716e+289%

QoQ Change in Holders

+15 / -3

Price History

$5.02$11.34$17.66$23.98$30.30Oct 24Jul 25Mar 26

SEPN — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
First Light Asset Management, LLCNew Position+621K+$17.3M
PRIMECAP MANAGEMENT CO/CA/New Position+546K+$15.2M
Universal- Beteiligungs- und Servicegesellschaft mbHNew Position+223K+$6.2M
Kalehua Capital Management LLCNew Position+195K+$5.4M
MARSHALL WACE, LLPNew Position+227K+$5.0M
FEDERATED HERMES, INC.New Position+79K+$2.0M
HighVista Strategies LLCNew Position+79K+$2.0M
Trexquant Investment LPNew Position+44K+$1.2M
Bank of New York Mellon CorpNew Position+55K+$1.0M
CITADEL ADVISORS LLCNew Position+76K+$1.0M
JANE STREET GROUP, LLCNew Position+44K+$1.0M
Numerai GP LLCNew Position+46K+$1.0M
ExodusPoint Capital Management, LPNew Position+38K+$1.0M
VARCOV Co.New Position+23K+$631K
STRS OHIONew Position+15K+$407K

SEPN — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
DRIEHAUS CAPITAL MANAGEMENT LLCDecreased-110K-$92.4B
BVF INC/ILDecreased-2.3M-$75.5B
Siren, L.L.C.Decreased-203K-$41.4B
VANGUARD GROUP INCDecreased-11K-$28.5B
ADAR1 Capital Management, LLCDecreased-19K-$22.1B
PERCEPTIVE ADVISORS LLCDecreased-108K-$10.2B
MILLENNIUM MANAGEMENT LLCDecreased-277K-$7.2B
Checkpoint Capital L.P.Closed Position-283K-$5.3B
Sio Capital Management, LLCClosed Position-189K-$3.6B
Invesco Ltd.Decreased-15K-$3.3B
NORTHERN TRUST CORPDecreased-13K-$3.1B
Rangeley Capital, LLCDecreased-22K-$1.7B
Logos Global Management LPDecreased-60K-$1.6B
Walleye Capital LLCClosed Position-80K-$1.5B
Longaeva Partners L.P.Decreased-7K-$1.1B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1RA CAPITAL MANAGEMENT, L.P.6,995,858$195.0M2.00%Share
2TRV GP V, LLC6,215,591$173.3M40.38%Share
3DRIEHAUS CAPITAL MANAGEMENT LLC4,809,470$134.1M0.91%Share
4TRV GP VI, LLC4,211,659$117.4M79.05%Share
5Samsara BioCapital, LLC3,149,128$87.8M9.06%Share
6Siren, L.L.C.2,000,000$55.8M1.66%Share
7BVF INC/IL1,720,782$48.0M1.61%Share
8GOLDMAN SACHS GROUP INC1,446,982$40.0M0.00%Share
9VANGUARD GROUP INC1,346,965$37.6M0.00%Share
10Avoro Capital Advisors LLC1,337,500$37.3M0.37%Share
11GOLDMAN SACHS GROUP INC1,268,147$35.0M0.00%Share
12ADAR1 Capital Management, LLC1,157,611$32.3M2.34%Share
13BlackRock, Inc.1,021,290$28.0M0.00%Share
14First Light Asset Management, LLC620,811$17.3M1.32%Share
15VR Adviser, LLC610,808$17.0M0.84%Share
16BlackRock, Inc.605,396$16.0M0.00%Share
17Casdin Capital, LLC553,268$15.4M0.96%Share
18PRIMECAP MANAGEMENT CO/CA/546,100$15.2M0.01%Share
19STATE STREET CORP540,028$15.0M0.00%Share
20GEODE CAPITAL MANAGEMENT, LLC499,514$13.0M0.00%Share
21PERCEPTIVE ADVISORS LLC433,160$12.1M0.22%Share
22Soleus Capital Management, L.P.383,368$10.7M0.39%Share
23Woodline Partners LP385,310$10.0M0.04%Share
24Catalio Capital Management, LP294,360$8.2M1.45%Share
25Universal- Beteiligungs- und Servicegesellschaft mbH222,702$6.2M0.01%Share
26Kalehua Capital Management LLC194,544$5.4M5.36%Share
27MARSHALL WACE, LLP199,576$5.0M0.00%Share
28CHARLES SCHWAB INVESTMENT MANAGEMENT INC187,241$5.0M0.00%Share
29Invesco Ltd.150,133$4.2M0.00%Share
30VANGUARD GROUP INC149,641$4.2M0.00%Share
31NORTHERN TRUST CORP150,584$4.0M0.00%Share
32GEODE CAPITAL MANAGEMENT, LLC73,220$2.0M0.00%Share
33TWO SIGMA INVESTMENTS, LP92,809$2.0M0.00%Share
34MILLENNIUM MANAGEMENT LLC107,463$2.0M0.00%Share
35JANE STREET GROUP, LLC80,200$2.0M0.00%Put
36SUSQUEHANNA INTERNATIONAL GROUP, LLP99,400$2.0M0.00%Put
37FEDERATED HERMES, INC.75,328$2.0M0.00%Share
38HighVista Strategies LLC78,682$2.0M0.52%Share
39UBS Group AG68,525$1.9M0.00%Share
40Rangeley Capital, LLC65,800$1.8M1.52%Share
41Longaeva Partners L.P.49,902$1.4M0.12%Share
42Trexquant Investment LP44,005$1.2M0.01%Share
43JACOBS LEVY EQUITY MANAGEMENT, INC61,370$1.0M0.00%Share
44Bank of New York Mellon Corp35,975$1.0M0.00%Share
45SUSQUEHANNA INTERNATIONAL GROUP, LLP69,200$1.0M0.00%Call
46MORGAN STANLEY37,045$1.0M0.00%Share
47BlackRock, Inc.63,772$1.0M0.00%Share
48CITADEL ADVISORS LLC42,179$1.0M0.00%Share
49JANE STREET GROUP, LLC42,472$1.0M0.00%Share
50BARCLAYS PLC38,137$1.0M0.00%Share

SEPN Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025122$1.2B+51
Q3 202571$832.1B-1
Q2 202572$367.1B+1
Q1 202571$261.8B+1
Q4 202470$997.7B—

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As of Q4 2025, 50 institutional investors hold SEPN (Septerna, Inc.). The largest holder is RA CAPITAL MANAGEMENT, L.P. with $195.0M in shares. This quarter, 15 institutions opened new positions and 3 closed their positions.

Frequently Asked Questions

How many hedge funds own SEPN?

As of Q4 2025, 50 institutional investors report holding SEPN (Septerna, Inc.) in their 13F filings.

Who is the largest institutional holder of SEPN?

The largest institutional holder of SEPN is RA CAPITAL MANAGEMENT, L.P. with $195.0M in shares.

Is institutional ownership of SEPN increasing or decreasing?

This quarter, 15 institutions opened new positions in SEPN and 3 closed their positions.