Who Owns Rhythm Pharmaceuticals, Inc. (RYTM)?Hedge Fund & Institutional Holders

$86.67-4.48 (-4.91%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

Infinity%

QoQ Change in Holders

+6 / -5

Price History

$46.95$64.62$82.28$99.95$117.62Sep 24Jun 25Mar 26

RYTM — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
FEDERATED HERMES, INC.New Position+1.6M+$172.0B
JENNISON ASSOCIATES LLCNew Position+919K+$98.3B
Point72 Asset Management, L.P.New Position+429K+$45.0B
Capital Research Global InvestorsIncreased+387K+$44.6B
JPMORGAN CHASE & COIncreased+236K+$30.0B
Checkpoint Capital L.P.Increased+228K+$29.1B
Integral Health Asset Management, LLCIncreased+255K+$28.6B
WESTFIELD CAPITAL MANAGEMENT CO LPIncreased+198K+$27.0B
WELLINGTON MANAGEMENT GROUP LLPIncreased+226K+$20.5B
Invesco Ltd.Increased+148K+$16.7B
First Turn Management, LLCNew Position+146K+$15.7B
FRANKLIN RESOURCES INCIncreased+128K+$15.7B
Woodline Partners LPIncreased+109K+$14.4B
M&G PlcNew Position+137K+$14.0B
M&T BANK CORPNew Position+86K+$13.8B

RYTM — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
ALKEON CAPITAL MANAGEMENT LLCClosed Position-1.0M-$102.8B
PRIMECAP MANAGEMENT CO/CA/Decreased-784K-$58.2B
VOLORIDGE INVESTMENT MANAGEMENT, LLCDecreased-308K-$37.2B
BALYASNY ASSET MANAGEMENT L.P.Decreased-278K-$28.3B
SILVERARC CAPITAL MANAGEMENT, LLCDecreased-234K-$22.8B
Assenagon Asset Management S.A.Closed Position-224K-$22.6B
COMERICA BANKDecreased-205K-$20.7B
RENAISSANCE TECHNOLOGIES LLCDecreased-205K-$19.2B
MARSHALL WACE, LLPClosed Position-172K-$17.4B
PERCEPTIVE ADVISORS LLCDecreased-416.6M-$15.8B
ROYAL BANK OF CANADADecreased-124K-$12.7B
Man Group plcDecreased-120K-$12.1B
Ensign Peak Advisors, IncDecreased-108K-$11.3B
PANAGORA ASSET MANAGEMENT INCClosed Position-65K-$6.5B
Walleye Capital LLCClosed Position-50K-$5.1B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1BAKER BROS. ADVISORS LP5,604,483$599.9B3512.60%Share
2PRIMECAP MANAGEMENT CO/CA/3,478,669$372.4B281.85%Share
3NEA Management Company, LLC2,909,956$311.5B15.88%Share
4PERCEPTIVE ADVISORS LLC2,546,391$272.6B4858.31%Share
5GOLDMAN SACHS GROUP INC1,629,650$174.0B21.45%Share
6FEDERATED HERMES, INC.1,395,672$149.0B248.93%Share
7FMR LLC1,381,054$147.0B7.50%Share
8JPMORGAN CHASE & CO1,297,904$138.0B8.66%Share
9DRIEHAUS CAPITAL MANAGEMENT LLC1,285,222$137.6B934.45%Share
10WESTFIELD CAPITAL MANAGEMENT CO LP1,267,158$135.0B562.38%Share
11Polar Capital Holdings Plc1,185,392$126.0B486.92%Share
12JANUS HENDERSON GROUP PLC1,096,903$117.0B52.39%Share
13Checkpoint Capital L.P.992,200$106.2B33.18%Share
14Capital Research Global Investors985,086$105.0B19.38%Share
15ALLIANCEBERNSTEIN L.P.930,233$99.0B31.26%Share
16JENNISON ASSOCIATES LLC789,784$84.5B50.75%Share
17Rock Springs Capital Management LP695,010$74.4B3.81%Share
18Woodline Partners LP688,779$73.0B282.85%Share
19ADAGE CAPITAL PARTNERS GP, L.L.C.621,585$66.0B99.89%Share
20CHARLES SCHWAB INVESTMENT MANAGEMENT INC532,447$56.0B8.70%Share
21Clearbridge Investments, LLC506,109$54.0B43.23%Share
22Siren, L.L.C.499,975$53.5B1.60%Share
23Integral Health Asset Management, LLC475,000$50.8B2.52%Share
24NORTHERN TRUST CORP433,779$46.0B5.86%Share
25Point72 Asset Management, L.P.429,420$45.0B50.32%Share
26LOOMIS SAYLES & CO L P411,449$44.0B53.04%Share
27FRANKLIN RESOURCES INC403,897$43.0B10.55%Share
28RENAISSANCE TECHNOLOGIES LLC341,193$36.0B55.85%Share
29First Light Asset Management, LLC295,844$31.7B2.42%Share
30UBS Group AG283,049$30.3B4.91%Share
31Candriam S.C.A.287,907$30.0B149.39%Share
32Sofinnova Investments, Inc.271,394$29.1B1.25%Share
33Sio Capital Management, LLC265,700$28.4B4.47%Put
34Artisan Partners Limited Partnership263,591$28.0B41.92%Share
35FMR LLC245,160$26.0B1.33%Share
36ORBIMED ADVISORS LLC239,800$25.7B0.52%Share
37Hood River Capital Management LLC237,043$25.4B278.16%Share
38FEDERATED HERMES, INC.222,933$23.0B38.43%Share
39SUSQUEHANNA INTERNATIONAL GROUP, LLP212,800$22.0B2.53%Call
40AMERIPRISE FINANCIAL INC210,155$22.0B4.97%Share
41GOLDMAN SACHS GROUP INC198,860$21.0B2.59%Share
42Logos Global Management LP190,000$20.3B1.23%Share
43Invesco Ltd.188,964$20.2B3.10%Share
44MILLENNIUM MANAGEMENT LLC186,709$19.0B7.99%Share
45First Turn Management, LLC146,303$15.7B1.79%Share
46BANK OF AMERICA CORP /DE/146,519$15.0B1.09%Share
47FRANKLIN RESOURCES INC147,375$15.0B3.68%Share
48VOYA INVESTMENT MANAGEMENT LLC143,371$15.0B14.79%Share
49FRANKLIN RESOURCES INC144,288$15.0B3.68%Share
50Connor, Clark & Lunn Investment Management Ltd.149,373$15.0B39.34%Share

RYTM Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025277$4.7T+66
Q3 2025211$4.7T+16
Q2 2025195$2.6T-34
Q1 2025229$2.9T+32
Q4 2024197$2.7T+45
Q3 2024152$30.3T+10
Q2 2024142$29.6T+4
Q1 2024138$872.3T—

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As of Q4 2025, 50 institutional investors hold RYTM (Rhythm Pharmaceuticals, Inc.). The largest holder is BAKER BROS. ADVISORS LP with $599.9B in shares. This quarter, 6 institutions opened new positions and 5 closed their positions.

Frequently Asked Questions

How many hedge funds own RYTM?

As of Q4 2025, 50 institutional investors report holding RYTM (Rhythm Pharmaceuticals, Inc.) in their 13F filings.

Who is the largest institutional holder of RYTM?

The largest institutional holder of RYTM is BAKER BROS. ADVISORS LP with $599.9B in shares.

Is institutional ownership of RYTM increasing or decreasing?

This quarter, 6 institutions opened new positions in RYTM and 5 closed their positions.