Who Owns Sionna Therapeutics, Inc. (SION)?Hedge Fund & Institutional Holders

$37.13+0.46 (+1.24%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

1.422200412668955e+278%

QoQ Change in Holders

+7 / -4

Price History

$7.66$16.86$26.07$35.27$44.48Feb 25Aug 25Mar 26

SION — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
JENNISON ASSOCIATES LLCNew Position+1.1M+$45.9B
CITADEL ADVISORS LLCIncreased+1.1M+$42.9B
EVENTIDE ASSET MANAGEMENT, LLCNew Position+639K+$26.3B
Artia Global Partners LPNew Position+120K+$4.9B
Invesco Ltd.New Position+111K+$4.6B
Ensign Peak Advisors, IncNew Position+80K+$3.0B
UBS Group AGIncreased+43K+$2.3B
CHARLES SCHWAB INVESTMENT MANAGEMENT INCIncreased+12K+$1.7B
Longaeva Partners L.P.Increased+18K+$1.5B
TD ASSET MANAGEMENT INCIncreased+26K+$1.4B
NORTHERN TRUST CORPIncreased+14K+$1.1B
MANUFACTURERS LIFE INSURANCE COMPANY, THEIncreased+37K+$1.1B
ALPS ADVISORS INCNew Position+37K+$1.0B
Rafferty Asset Management, LLCNew Position+25K+$1.0B
BANK OF AMERICA CORP /DE/Increased+37K+$999.8M

SION — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
RA CAPITAL MANAGEMENT, L.P.Decreased-540K-$306.8B
JPMORGAN CHASE & CODecreased-747K-$9.2B
MILLENNIUM MANAGEMENT LLCDecreased-134K-$3.3B
SILVERARC CAPITAL MANAGEMENT, LLCDecreased-67K-$1.5B
Holocene Advisors, LPClosed Position-50K-$1.5B
Soleus Capital Management, L.P.Decreased-145K-$1.1B
MARSHALL WACE, LLPClosed Position-30K-$885.3M
AMERIPRISE FINANCIAL INCDecreased-52K-$504.2M
Alyeska Investment Group, L.P.Decreased-50K-$476.8M
RENAISSANCE TECHNOLOGIES LLCClosed Position-15K-$429.4M
Jain Global LLCClosed Position-9K-$250.4M
WELLINGTON MANAGEMENT GROUP LLPDecreased-4K-$242.1M
Legal & General Group PlcDecreased-6K-$217.2M
Tower Research Capital LLC (TRC)Decreased-3K-$132.1M
FRANKLIN RESOURCES INCDecreased-67K-$121.5M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1ORBIMED ADVISORS LLC3,561,655$146.5B2.99%Share
2VIKING GLOBAL INVESTORS LP3,195,181$131.4B0.35%Share
3Atlas Venture Life Science Advisors, LLC2,995,602$123.2B14.24%Share
4Enavate Sciences GP, LLC2,478,030$101.9B20.12%Share
5PERCEPTIVE ADVISORS LLC1,179,098$48.5B0.86%Share
6JENNISON ASSOCIATES LLC1,115,278$45.9B0.03%Share
7CITADEL ADVISORS LLC1,087,325$44.0B0.01%Share
8JPMORGAN CHASE & CO1,025,078$42.0B0.00%Share
9DEERFIELD MANAGEMENT COMPANY, L.P.970,590$39.9B0.51%Share
10Aberdeen Group plc839,960$34.6B0.05%Share
11EVENTIDE ASSET MANAGEMENT, LLC639,045$26.3B0.41%Share
12BAKER BROS. ADVISORS LP400,000$16.5B0.10%Share
13Siren, L.L.C.300,000$12.3B0.37%Share
14Soleus Capital Management, L.P.268,500$11.0B0.41%Share
15FRANKLIN RESOURCES INC175,483$7.0B0.00%Share
16JPMORGAN CHASE & CO167,619$6.0B0.00%Share
17Alyeska Investment Group, L.P.136,222$5.0B0.01%Share
18CHARLES SCHWAB INVESTMENT MANAGEMENT INC123,686$5.0B0.00%Share
19Artia Global Partners LP119,741$4.9B0.70%Share
20Invesco Ltd.104,268$4.3B0.00%Share
21Rock Springs Capital Management LP99,429$4.1B0.21%Share
22AMERIPRISE FINANCIAL INC101,643$4.0B0.00%Share
23TD ASSET MANAGEMENT INC113,352$4.0B0.00%Share
24NORTHERN TRUST CORP109,600$4.0B0.00%Share
25UBS Group AG88,446$3.6B0.00%Share
26DRIEHAUS CAPITAL MANAGEMENT LLC83,850$3.4B0.02%Share
27Longaeva Partners L.P.79,729$3.3B0.28%Share
28MILLENNIUM MANAGEMENT LLC80,546$3.0B0.00%Share
29Ensign Peak Advisors, Inc79,862$3.0B0.01%Share
30MANUFACTURERS LIFE INSURANCE COMPANY, THE69,424$2.0B0.00%Share
31SILVERARC CAPITAL MANAGEMENT, LLC41,460$1.7B0.24%Share
32POLEN CAPITAL MANAGEMENT LLC31,258$1.3B0.01%Share
33ALPS ADVISORS INC36,648$1.0B0.01%Share
34GOLDMAN SACHS GROUP INC26,886$1.0B0.00%Share
35JPMORGAN CHASE & CO35,604$1.0B0.00%Share
36WELLINGTON MANAGEMENT GROUP LLP25,696$1.0B0.00%Share
37Rafferty Asset Management, LLC24,690$1.0B0.00%Share
38BANK OF AMERICA CORP /DE/31,351$1.0B0.00%Share
39BARCLAYS PLC48,172$1.0B0.00%Share
40RA CAPITAL MANAGEMENT, L.P.9,905,045$407.5M4.17%Share
41TPG GP A, LLC6,744,962$277.5M10.33%Share
42KENNEDY CAPITAL MANAGEMENT LLC6,752$277.0M0.01%Share
43Virtus Investment Advisers, LLC6,220$255.0M0.07%Share
44Invesco Ltd.4,676$192.0M0.00%Share
45Invesco Ltd.2,218$91.0M0.00%Share
46VANGUARD GROUP INC1,070,817$44.0M0.00%Share
47GF FUND MANAGEMENT CO. LTD.876$36.0M0.00%Share
48PRICE T ROWE ASSOCIATES INC /MD/818,250$33.0M0.00%Share
49BlackRock, Inc.783,071$32.0M0.00%Share
50STATE STREET CORP693,395$28.0M0.00%Share

SION Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025100$902.6B+28
Q3 202572$1.1T+19
Q2 202553$674.3B+6
Q1 202547$325.3B—

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As of Q4 2025, 50 institutional investors hold SION (Sionna Therapeutics, Inc.). The largest holder is ORBIMED ADVISORS LLC with $146.5B in shares. This quarter, 7 institutions opened new positions and 4 closed their positions.

Frequently Asked Questions

How many hedge funds own SION?

As of Q4 2025, 50 institutional investors report holding SION (Sionna Therapeutics, Inc.) in their 13F filings.

Who is the largest institutional holder of SION?

The largest institutional holder of SION is ORBIMED ADVISORS LLC with $146.5B in shares.

Is institutional ownership of SION increasing or decreasing?

This quarter, 7 institutions opened new positions in SION and 4 closed their positions.