| 1 | SUVRETTA CAPITAL MANAGEMENT, LLC | 892,400 | $93.4M | 1.91% | Share |
| 2 | BVF INC/IL | 879,009 | $92.0M | 3.10% | Share |
| 3 | Frazier Life Sciences Management, L.P. | 722,400 | $75.6M | 2.03% | Share |
| 4 | First Light Asset Management, LLC | 709,141 | $74.2M | 5.67% | Share |
| 5 | VANGUARD GROUP INC | 495,710 | $51.9M | 0.00% | Share |
| 6 | STATE STREET CORP | 420,462 | $44.0M | 0.00% | Share |
| 7 | SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 389,420 | $40.8M | 0.85% | Share |
| 8 | JENNISON ASSOCIATES LLC | 387,483 | $40.6M | 0.02% | Share |
| 9 | FEDERATED HERMES, INC. | 368,038 | $38.0M | 0.06% | Share |
| 10 | Woodline Partners LP | 300,536 | $31.0M | 0.12% | Share |
| 11 | BlackRock, Inc. | 282,836 | $29.0M | 0.00% | Share |
| 12 | ALLIANCEBERNSTEIN L.P. | 269,027 | $28.0M | 0.01% | Share |
| 13 | PERCEPTIVE ADVISORS LLC | 266,287 | $27.9M | 0.50% | Share |
| 14 | FMR LLC | 231,671 | $24.0M | 0.00% | Share |
| 15 | BlackRock, Inc. | 224,558 | $23.0M | 0.00% | Share |
| 16 | Artisan Partners Limited Partnership | 211,553 | $22.0M | 0.03% | Share |
| 17 | MPM BioImpact LLC | 205,745 | $21.5M | 2.46% | Share |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 154,492 | $16.0M | 0.00% | Share |
| 19 | FRED ALGER MANAGEMENT, LLC | 150,026 | $15.0M | 0.06% | Share |
| 20 | MORGAN STANLEY | 120,510 | $12.0M | 0.00% | Share |
| 21 | BALYASNY ASSET MANAGEMENT L.P. | 108,880 | $11.0M | 0.01% | Share |
| 22 | Samsara BioCapital, LLC | 104,817 | $11.0M | 1.13% | Share |
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 101,748 | $10.6M | 0.17% | Share |
| 24 | Caption Management, LLC | 96,000 | $10.0M | 0.07% | Call |
| 25 | Caption Management, LLC | 95,300 | $10.0M | 0.07% | Put |
| 26 | Clio Asset Management LLC | 91,642 | $9.6M | 7.45% | Share |
| 27 | GOLDMAN SACHS GROUP INC | 92,112 | $9.0M | 0.00% | Share |
| 28 | NEXTBio Capital Management LP | 82,686 | $8.7M | 5.08% | Share |
| 29 | Point72 Asset Management, L.P. | 77,297 | $8.0M | 0.01% | Share |
| 30 | MORGAN STANLEY | 77,070 | $8.0M | 0.00% | Share |
| 31 | Siren, L.L.C. | 75,000 | $7.8M | 0.23% | Share |
| 32 | AWM Investment Company, Inc. | 69,416 | $7.3M | 0.70% | Share |
| 33 | Artia Global Partners LP | 59,200 | $6.2M | 0.88% | Share |
| 34 | Clearbridge Investments, LLC | 60,628 | $6.0M | 0.00% | Share |
| 35 | VANGUARD GROUP INC | 53,879 | $5.6M | 0.00% | Share |
| 36 | Invesco Ltd. | 50,550 | $5.3M | 0.00% | Share |
| 37 | NORTHERN TRUST CORP | 52,682 | $5.0M | 0.00% | Share |
| 38 | Lisanti Capital Growth, LLC | 41,470 | $4.3M | 1.03% | Share |
| 39 | Blue Owl Capital Holdings LP | 40,259 | $4.2M | 0.32% | Share |
| 40 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,650 | $4.0M | 0.00% | Share |
| 41 | ROYCE & ASSOCIATES LP | 30,010 | $3.1M | 0.03% | Share |
| 42 | Neuberger Berman Group LLC | 31,123 | $3.0M | 0.00% | Share |
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,200 | $3.0M | 0.00% | Call |
| 44 | UBS Group AG | 27,543 | $2.9M | 0.00% | Share |
| 45 | SUPERSTRING CAPITAL MANAGEMENT LP | 25,469 | $2.7M | 1.43% | Share |
| 46 | Avidity Partners Management LP | 19,300 | $2.0M | 0.58% | Share |
| 47 | RENAISSANCE TECHNOLOGIES LLC | 22,530 | $2.0M | 0.00% | Share |
| 48 | GEODE CAPITAL MANAGEMENT, LLC | 24,500 | $2.0M | 0.00% | Share |
| 49 | JANE STREET GROUP, LLC | 24,000 | $2.0M | 0.00% | Call |
| 50 | SIG BROKERAGE, LP | 22,500 | $2.0M | 0.06% | Call |