$74.51
+2.62 (+3.64%)
Market Cap
$4.2B
Shares Outstanding
60,401,468
Institutional Holders
130
Total Inst. Value
$1.1B
% of Float Held
141.3%
QoQ Holder Change
+40
Institutional data as of Q1 2025
New Positions
20
Closed Positions
21
Increased
53
Decreased
35
Institutional Ownership Trend
Top 10 Institutional Holders(Q1 2025)
| # | Fund | Value | Shares |
|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | $203.3M | 12,600,000 |
| 2 | FMR LLC | $145.8M | 9,038,553 |
| 3 | Fairmount Funds Management LLC | $64.8M | 4,018,101 |
| 4 | BlackRock, Inc. | $57.6M | 3,572,674 |
| 5 | VANGUARD GROUP INC | $46.8M | 2,898,267 |
| 6 | DRIEHAUS CAPITAL MANAGEMENT LLC | $43.8M | 2,717,312 |
| 7 | VR Adviser, LLC | $43.3M | 2,685,448 |
| 8 | BRAIDWELL LP | $41.6M | 2,578,404 |
| 9 | Capital International InvestorsNew | $38.6M | 2,392,541 |
| 10 | PERCEPTIVE ADVISORS LLC | $37.3M | 2,313,272 |
Biggest Buyers & Sellers This Quarter
Top Buyers
| Fund | Shares Added | Value |
|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | +12.2M | $203.3M |
| FMR LLC | +237K | $145.8M |
| BlackRock, Inc. | +173K | $57.6M |
| VANGUARD GROUP INC | +52K | $46.8M |
| Capital International InvestorsNew | +2.4M | $38.6M |
Top Sellers
| Fund | Shares Removed | Value |
|---|---|---|
| CITADEL ADVISORS LLC | -948K | $62K |
| GOLDMAN SACHS GROUP INC | -550K | $3.2M |
| JANUS HENDERSON GROUP PLC | -415K | $252K |
| Affinity Asset Advisors, LLC | -343K | $7.8M |
| PERCEPTIVE ADVISORS LLC | -261K | $37.3M |
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Frequently Asked Questions
How many institutional investors hold SYRE?
As of Q1 2025, 130 institutional investors report holding SYRE (Spyre Therapeutics, Inc.) in their 13F filings.
What percentage of Spyre Therapeutics, Inc. is owned by institutions?
Institutional investors hold approximately 141.3% of Spyre Therapeutics, Inc.'s float as reported in SEC 13F filings.
Which hedge fund owns the most SYRE?
The largest institutional holder of SYRE is DEERFIELD MANAGEMENT COMPANY, L.P. with $203.3M in shares.
Are institutions buying or selling SYRE?
This quarter, 20 institutions opened new positions in SYRE and 21 closed their positions.
What is 13F institutional ownership?
SEC Form 13F is a quarterly report filed by institutional investment managers with over $100M in qualifying assets. It discloses their US equity holdings, providing transparency into what the largest investors are buying and selling.
How often is institutional ownership data updated?
13F filings are due 45 days after each calendar quarter end (May 15, Aug 14, Nov 14, Feb 14). Data is updated on HedgeTrace as new filings are processed.