SYRE
Spyre Therapeutics, Inc.$40.22-0.19 (-0.47%)HealthcareNASDAQ
Institutional Holders
50
as of Q4 2025
Total Shares Held
InfinityB
Total Value
$2.7400013667413166e+240T
% of Float
Infinity%
Price History
Top Institutional Holders(Q4 2025)
| # | Fund | Shares | Value | % of Portfolio | Type |
|---|---|---|---|---|---|
| 1 | FMR LLC | 8,365,485 | $274.0M | 0.01% | Share |
| 2 | RTW INVESTMENTS, LP | 4,171,996 | $136.7M | 1.37% | Share |
| 3 | Fairmount Funds Management LLC | 4,018,101 | $131.6M | 10.02% | Share |
| 4 | VR Adviser, LLC | 3,685,448 | $120.7M | 5.96% | Share |
| 5 | VANGUARD GROUP INC | 3,500,641 | $114.7M | 0.00% | Share |
| 6 | Capital International Investors | 3,492,541 | $114.0M | 0.02% | Share |
| 7 | FMR LLC | 3,165,797 | $103.0M | 0.01% | Share |
| 8 | PERCEPTIVE ADVISORS LLC | 3,069,225 | $100.5M | 1.79% | Share |
| 9 | BlackRock, Inc. | 3,013,796 | $98.0M | 0.00% | Share |
| 10 | DRIEHAUS CAPITAL MANAGEMENT LLC | 2,882,420 | $94.4M | 0.64% | Share |
| 11 | Commodore Capital LP | 2,388,245 | $78.2M | 5.21% | Share |
| 12 | STATE STREET CORP | 2,262,839 | $74.0M | 0.00% | Share |
| 13 | BlackRock, Inc. | 1,979,486 | $64.0M | 0.00% | Share |
| 14 | TCG Crossover Management, LLC | 1,900,582 | $62.3M | 2.06% | Share |
| 15 | TANG CAPITAL MANAGEMENT LLC | 1,892,200 | $62.0M | 3.06% | Share |
| 16 | JANUS HENDERSON GROUP PLC | 1,807,609 | $59.0M | 0.03% | Share |
| 17 | BRAIDWELL LP | 1,634,615 | $53.5M | 1.71% | Share |
| 18 | RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | $53.1M | 0.54% | Share |
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,524,649 | $49.0M | 0.01% | Share |
| 20 | Paradigm Biocapital Advisors LP | 1,467,266 | $48.1M | 1.23% | Share |
| 21 | Remedium Capital Partners, LLC | 1,456,231 | $47.7M | 28.03% | Share |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 1,436,198 | $47.0M | 0.00% | Share |
| 23 | Affinity Asset Advisors, LLC | 1,432,591 | $46.9M | 2.67% | Share |
| 24 | FRANKLIN RESOURCES INC | 1,109,227 | $36.0M | 0.01% | Share |
| 25 | BAKER BROS. ADVISORS LP | 1,000,000 | $32.8M | 0.19% | Share |
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 976,583 | $31.0M | 0.01% | Share |
| 27 | Pictet Asset Management Holding SA | 913,960 | $29.9M | 0.03% | Share |
| 28 | Siren, L.L.C. | 818,598 | $26.8M | 0.80% | Share |
| 29 | Polar Capital Holdings Plc | 740,326 | $24.0M | 0.09% | Share |
| 30 | DEERFIELD MANAGEMENT COMPANY, L.P. | 710,626 | $23.3M | 0.30% | Share |
| 31 | UBS Group AG | 676,123 | $22.1M | 0.00% | Share |
| 32 | Point72 Asset Management, L.P. | 662,351 | $21.0M | 0.02% | Share |
| 33 | EMERALD ADVISERS, LLC | 636,109 | $20.8M | 0.64% | Share |
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 574,622 | $18.0M | 0.00% | Share |
| 35 | Blackstone Inc. | 500,998 | $16.4M | 0.06% | Share |
| 36 | NORTHERN TRUST CORP | 515,556 | $16.0M | 0.00% | Share |
| 37 | VANGUARD GROUP INC | 460,091 | $15.1M | 0.00% | Share |
| 38 | EMERALD MUTUAL FUND ADVISERS TRUST | 412,371 | $13.5M | 0.66% | Share |
| 39 | Caption Management, LLC | 399,900 | $13.1M | 0.09% | Call |
| 40 | Candriam S.C.A. | 425,534 | $13.0M | 0.06% | Share |
| 41 | BANK OF AMERICA CORP /DE/ | 379,165 | $12.0M | 0.00% | Share |
| 42 | WELLINGTON MANAGEMENT GROUP LLP | 383,209 | $12.0M | 0.00% | Share |
| 43 | Woodline Partners LP | 265,892 | $8.0M | 0.03% | Share |
| 44 | GEODE CAPITAL MANAGEMENT, LLC | 222,942 | $7.0M | 0.00% | Share |
| 45 | ARMISTICE CAPITAL, LLC | 196,426 | $6.4M | 0.08% | Share |
| 46 | SILVERARC CAPITAL MANAGEMENT, LLC | 187,737 | $6.2M | 0.85% | Share |
| 47 | Capital World Investors | 200,172 | $6.0M | 0.00% | Share |
| 48 | HighVista Strategies LLC | 188,206 | $6.0M | 1.55% | Share |
| 49 | BlackRock, Inc. | 196,384 | $6.0M | 0.00% | Share |
| 50 | Universal- Beteiligungs- und Servicegesellschaft mbH | 171,211 | $5.6M | 0.01% | Share |