Who Owns Lexicon Pharmaceuticals, Inc. (LXRX)?Hedge Fund & Institutional Holders

$1.69-0.04 (-2.03%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$4.4756000220000006e+260T

% of Float Held

2.1647800350948595e+278%

QoQ Change in Holders

+12 / -2

Price History

$0.29$0.74$1.19$1.63$2.08Sep 24Jun 25Mar 26

LXRX — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
UBS Group AGIncreased+2.7M+$3.0B
Hennion & Walsh Asset Management, Inc.New Position+901K+$1.0B
GOLDMAN SACHS GROUP INCIncreased+862K+$919.9M
Quarry LPNew Position+88K+$101.0M
Straight Path Wealth ManagementNew Position+63K+$72.0M
State of WyomingNew Position+61K+$69.0M
EntryPoint Capital, LLCNew Position+34K+$38.0M
SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/New Position+27K+$30.0M
OPPENHEIMER & CO INCNew Position+24K+$27.0M
Invera Wealth Advisors, LLCNew Position+20K+$23.0M
Chemistry Wealth Management LLCNew Position+12K+$13.0M
NBT BANK N A /NYNew Position+10K+$11.0M
R Squared LtdIncreased+15K+$9.7M
Golden State Wealth Management, LLCNew Position+4K+$4.0M
SBI Securities Co., Ltd.New Position+3K+$3.0M

LXRX — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
CIBC Bancorp USA Inc.Closed Position-2.4M-$3.2B
CITADEL ADVISORS LLCDecreased-923K-$2.6B
CIBC Private Wealth Group LLCDecreased-450K-$1.2B
Schonfeld Strategic Advisors LLCDecreased-813K-$1.1B
ROYAL BANK OF CANADADecreased-716K-$975.0M
JACOBS LEVY EQUITY MANAGEMENT, INCClosed Position-693K-$935.2M
CHARLES SCHWAB INVESTMENT MANAGEMENT INCDecreased-90K-$545.3M
XTX Topco LtdDecreased-233K-$444.9M
AQR CAPITAL MANAGEMENT LLCDecreased-158K-$409.0M
RENAISSANCE TECHNOLOGIES LLCDecreased-29K-$394.7M
Monaco Asset Management SAMDecreased-233K-$338.5M
Quadrature Capital LtdDecreased-210K-$309.2M
Ikarian Capital, LLCDecreased-12K-$238.1M
Jefferies Financial Group Inc.Decreased-5K-$131.5M
LPL Financial LLCDecreased-4K-$123.2M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1Siren, L.L.C.38,918,903$44.8B1.34%Share
2FMR LLC19,587,729$22.0B1.12%Share
3FMR LLC18,243,478$20.0B1.02%Share
4MILLENNIUM MANAGEMENT LLC4,821,733$5.0B2.10%Share
5UBS Group AG2,939,035$3.4B0.55%Share
6CIBC Private Wealth Group LLC1,950,000$2.0B3.38%Share
7Hennion & Walsh Asset Management, Inc.901,222$1.0B0.04%Share
8GOLDMAN SACHS GROUP INC900,438$1.0B0.12%Share
9CHARLES SCHWAB INVESTMENT MANAGEMENT INC1,055,123$1.0B0.16%Share
10CITADEL ADVISORS LLC1,710,975$1.0B0.15%Share
11SUSQUEHANNA INTERNATIONAL GROUP, LLP1,194,085$1.0B0.12%Share
12Invesco Ltd.594,883$684.0M0.10%Share
13Compagnie Lombard Odier SCmA410,000$471.0M5.12%Share
14GROUP ONE TRADING LLC224,308$257.0M0.45%Share
15Artal Group S.A.136,180,481$156.6M21.91%Share
16GROUP ONE TRADING LLC123,500$142.0M0.25%Call
17Monaco Asset Management SAM117,188$134.0M0.02%Share
18Quarry LP88,000$101.0M0.02%Share
19Straight Path Wealth Management62,666$72.0M0.02%Share
20State of Wyoming60,571$69.0M0.01%Share
21UBS Group AG56,352$64.0M0.01%Share
22Optiver Holding B.V.52,595$60.0M0.02%Share
23Fortis Group Advisors, LLC50,000$58.0M0.01%Share
24R Squared Ltd46,579$53.0M0.02%Share
25KWB Wealth40,640$46.0M0.00%Share
26Catalyst Funds Management Pty Ltd40,300$46.0M0.01%Share
27EntryPoint Capital, LLC33,618$38.0M0.01%Share
28Vermillion & White Wealth Management Group, LLC32,000$36.0M0.02%Share
29PINNACLE ASSOCIATES LTD29,015$33.0M0.42%Share
30SECURITY NATIONAL BANK OF SIOUX CITY IOWA /IA/26,650$30.0M0.02%Share
31GROUP ONE TRADING LLC25,100$28.0M0.05%Put
32OPPENHEIMER & CO INC23,500$27.0M0.38%Share
33Invera Wealth Advisors, LLC20,000$23.0M0.01%Share
34Chemistry Wealth Management LLC12,000$13.0M0.00%Share
35Perennial Investment Advisors, LLC10,990$12.0M0.00%Share
36Berger Financial Group, Inc10,000$11.0M0.00%Share
37UBS Group AG9,636$11.0M0.00%Share
38NBT BANK N A /NY10,000$11.0M0.00%Share
39VANGUARD GROUP INC8,424,399$9.0M0.13%Share
40Golden State Wealth Management, LLC3,700$4.0M0.00%Share
41Sessa Capital IM, L.P.3,000,000$3.5M0.06%Share
42SBI Securities Co., Ltd.3,018$3.0M0.00%Share
43BlackRock, Inc.3,168,726$3.0M0.05%Share
44Farther Finance Advisors, LLC2,755$3.0M0.03%Share
45Caitong International Asset Management Co., Ltd2,484$2.0M0.01%Share
46NISA INVESTMENT ADVISORS, LLC2,592$2.0M0.01%Share
47UBS Group AG2,214$2.0M0.00%Share
48Ishara Investments LP880,000$1.0M1.16%Share
49VANGUARD GROUP INC1,110,945$1.0M0.01%Share
50STATE STREET CORP884,738$1.0M0.00%Share

LXRX Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025123$104.7B+27
Q3 202596$269.4B-8
Q2 2025104$53.8B-22
Q1 2025126$83.5B+2
Q4 2024124$161.4B+5
Q3 2024119$2.5T+9
Q2 2024110$15.1T+15
Q1 202495$27.6T—

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As of Q4 2025, 50 institutional investors hold LXRX (Lexicon Pharmaceuticals, Inc.). The largest holder is Siren, L.L.C. with $44.8B in shares. This quarter, 12 institutions opened new positions and 2 closed their positions.

Frequently Asked Questions

How many hedge funds own LXRX?

As of Q4 2025, 50 institutional investors report holding LXRX (Lexicon Pharmaceuticals, Inc.) in their 13F filings.

Who is the largest institutional holder of LXRX?

The largest institutional holder of LXRX is Siren, L.L.C. with $44.8B in shares.

Is institutional ownership of LXRX increasing or decreasing?

This quarter, 12 institutions opened new positions in LXRX and 2 closed their positions.