| 1 | Artisan Partners Limited Partnership | 3,309,055 | $63.0M | 0.09% | Share |
| 2 | Vivo Capital, LLC | 2,461,626 | $47.2M | 3.05% | Share |
| 3 | Siren, L.L.C. | 1,857,362 | $35.6M | 1.06% | Share |
| 4 | BAKER BROS. ADVISORS LP | 1,461,425 | $28.0M | 0.16% | Share |
| 5 | MPM BioImpact LLC | 996,825 | $19.1M | 2.19% | Share |
| 6 | Yiheng Capital Management, L.P. | 639,769 | $12.3M | 2.48% | Share |
| 7 | MILLENNIUM MANAGEMENT LLC | 640,885 | $12.0M | 0.01% | Share |
| 8 | Octagon Capital Advisors LP | 574,200 | $11.0M | 1.34% | Share |
| 9 | Redmile Group, LLC | 549,840 | $10.5M | 0.78% | Share |
| 10 | Schonfeld Strategic Advisors LLC | 454,343 | $8.7M | 0.04% | Share |
| 11 | Patient Square Capital LP | 359,050 | $6.9M | 1.47% | Share |
| 12 | Vestal Point Capital, LP | 300,000 | $5.8M | 0.20% | Share |
| 13 | Squadron Capital Management LLC | 240,000 | $4.6M | 1.95% | Share |
| 14 | UBS Group AG | 234,762 | $4.5M | 0.00% | Share |
| 15 | BALYASNY ASSET MANAGEMENT L.P. | 235,023 | $4.0M | 0.01% | Share |
| 16 | NEW YORK STATE COMMON RETIREMENT FUND | 223,186 | $4.0M | 0.01% | Share |
| 17 | BOOTHBAY FUND MANAGEMENT, LLC | 163,401 | $3.0M | 0.04% | Share |
| 18 | Ikarian Capital, LLC | 525,000 | $2.1M | 0.16% | Share |
| 19 | MORGAN STANLEY | 122,129 | $2.0M | 0.00% | Share |
| 20 | CITADEL ADVISORS LLC | 145,129 | $2.0M | 0.00% | Share |
| 21 | Atika Capital Management LLC | 116,735 | $2.0M | 0.21% | Share |
| 22 | Polymer Capital Management (HK) LTD | 64,500 | $1.2M | 0.18% | Share |
| 23 | SEI INVESTMENTS CO | 66,341 | $1.0M | 0.00% | Share |
| 24 | Atika Capital Management LLC | 57,275 | $1.0M | 0.11% | Share |
| 25 | Optiver Holding B.V. | 47,728 | $914K | 0.00% | Share |
| 26 | NAN FUNG TRINITY (HK) Ltd | 37,095 | $711K | 0.06% | Share |
| 27 | Logos Global Management LP | 25,000 | $479K | 0.03% | Share |
| 28 | UBS Group AG | 10,100 | $193K | 0.00% | Share |
| 29 | Persistent Asset Partners Ltd | 6,019 | $115K | 0.05% | Share |
| 30 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 1,257 | $108K | 0.00% | Share |
| 31 | Truvestments Capital LLC | 3,892 | $74K | 0.01% | Share |
| 32 | GAMMA Investing LLC | 2,680 | $51K | 0.00% | Share |
| 33 | Allworth Financial LP | 1,683 | $32K | 0.00% | Share |
| 34 | EverSource Wealth Advisors, LLC | 479 | $9K | 0.00% | Share |
| 35 | MARK SHEPTOFF FINANCIAL PLANNING, LLC | 300 | $5K | 0.00% | Share |
| 36 | WELLS FARGO & COMPANY/MN | 300 | $0 | 0.00% | Share |
| 37 | CURIO WEALTH, LLC | 27 | $0 | 0.00% | Share |
| 38 | Engineers Gate Manager LP | 24,984 | $0 | 0.00% | Share |
| 39 | JPMORGAN CHASE & CO | 28,359 | $0 | 0.00% | Share |
| 40 | TRUST CO OF TOLEDO NA /OH/ | 10 | $0 | 0.00% | Share |
| 41 | Cetera Investment Advisers | 13,115 | $0 | 0.00% | Share |
| 42 | OSAIC HOLDINGS, INC. | 343 | $0 | 0.00% | Share |
| 43 | Qube Research & Technologies Ltd | 13,736 | $0 | 0.00% | Share |
| 44 | ExodusPoint Capital Management, LP | 27,211 | $0 | 0.00% | Share |
| 45 | Federation des caisses Desjardins du Quebec | 145 | $0 | 0.00% | Share |
| 46 | RHUMBLINE ADVISERS | 6,433 | $0 | 0.00% | Share |
| 47 | MARSHALL WACE, LLP | 2,877 | $0 | 0.00% | Share |
| 48 | MARSHALL WACE, LLP | 18,084 | $0 | 0.00% | Share |
| 49 | ROYAL BANK OF CANADA | 44 | $0 | 0.00% | Share |
| 50 | ROYAL BANK OF CANADA | 1,708 | $0 | 0.00% | Share |