Who Owns Structure Therapeutics Inc. (GPCR)?Hedge Fund & Institutional Holders

$53.78-0.80 (-1.47%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$5.15000455938432e+249T

% of Float Held

—

QoQ Change in Holders

+14 / -2

Price History

$14.15$34.06$53.97$73.88$93.79Aug 24Jun 25Mar 26

GPCR — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
PRICE T ROWE ASSOCIATES INC /MD/Increased+1.4M+$107.9M
PRINCIPAL FINANCIAL GROUP INCNew Position+1.3M+$89.3M
Capitolis Liquid Global Markets LLCNew Position+878K+$61.0M
DEUTSCHE BANK AG\New Position+841K+$58.0M
PACIFIC HEIGHTS ASSET MANAGEMENT LLCNew Position+700K+$48.7M
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUNDNew Position+468K+$32.0M
FARALLON CAPITAL MANAGEMENT LLCNew Position+454K+$31.6M
EcoR1 Capital, LLCNew Position+334K+$23.3M
Capricorn Fund Managers LtdNew Position+253K+$17.6M
VOLORIDGE INVESTMENT MANAGEMENT, LLCNew Position+250K+$17.0M
Sio Capital Management, LLCNew Position+202K+$14.0M
MARSHALL WACE, LLPNew Position+169K+$11.0M
JANE STREET GROUP, LLCNew Position+147K+$10.0M
RTW INVESTMENTS, LPNew Position+100K+$7.0M
SummitTX Capital, L.P.New Position+95K+$6.6M

GPCR — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Deep Track Capital, LPDecreased-104K-$117.8B
BAKER BROS. ADVISORS LPDecreased-124K-$43.5B
Casdin Capital, LLCDecreased-380K-$43.5B
RA CAPITAL MANAGEMENT, L.P.Closed Position-1.5M-$42.5B
MILLENNIUM MANAGEMENT LLCDecreased-1.1M-$35.7B
AMERIPRISE FINANCIAL INCDecreased-939K-$34.3B
TCG Crossover Management, LLCDecreased-142K-$29.7B
Rock Springs Capital Management LPDecreased-203K-$26.6B
Logos Global Management LPDecreased-250K-$23.8B
Catalio Capital Management, LPDecreased-399K-$18.2B
Aberdeen Group plcDecreased-322K-$16.4B
GOLDMAN SACHS GROUP INCDecreased-280K-$14.1B
BALYASNY ASSET MANAGEMENT L.P.Decreased-245K-$12.9B
Invesco Ltd.Decreased-441K-$12.4B
Point72 Asset Management, L.P.Closed Position-408K-$11.4B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1FMR LLC7,413,121$515.0M0.03%Share
2Avoro Capital Advisors LLC6,555,555$455.9M4.48%Share
3WELLINGTON MANAGEMENT GROUP LLP6,215,242$432.0M0.08%Share
4JANUS HENDERSON GROUP PLC4,945,939$343.0M0.15%Share
5Deep Track Capital, LP4,111,782$286.0M5.10%Share
6BVF INC/IL3,479,022$242.0M8.15%Share
7MORGAN STANLEY1,723,086$119.0M0.01%Share
8PRICE T ROWE ASSOCIATES INC /MD/1,671,138$116.0M0.01%Share
9DRIEHAUS CAPITAL MANAGEMENT LLC1,642,444$114.2M0.78%Share
10BAKER BROS. ADVISORS LP1,432,529$99.6M0.58%Share
11PRINCIPAL FINANCIAL GROUP INC1,284,210$89.3M0.05%Share
12Casdin Capital, LLC1,175,000$81.7M5.08%Share
13ORBIMED ADVISORS LLC1,161,803$80.8M1.65%Share
14Siren, L.L.C.1,078,698$75.0M2.24%Share
15TCG Crossover Management, LLC920,857$64.0M2.12%Share
16Capitolis Liquid Global Markets LLC878,300$61.0M0.36%Share
17FRANKLIN RESOURCES INC864,632$60.0M0.01%Share
18ALLIANCEBERNSTEIN L.P.848,851$59.0M0.02%Share
19DEUTSCHE BANK AG\841,162$58.0M0.02%Share
20DEERFIELD MANAGEMENT COMPANY, L.P.767,993$53.4M0.68%Share
21CITADEL ADVISORS LLC772,518$53.0M0.01%Share
22Rock Springs Capital Management LP748,236$52.0M2.67%Share
23PACIFIC HEIGHTS ASSET MANAGEMENT LLC700,000$48.7M1.82%Share
24Logos Global Management LP600,000$41.7M2.52%Share
25FMR LLC561,516$39.0M0.00%Share
26WELLINGTON MANAGEMENT GROUP LLP533,138$37.0M0.01%Share
27AMERICAN CENTURY COMPANIES INC506,959$35.0M0.02%Share
28HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND467,800$32.0M0.05%Share
29FARALLON CAPITAL MANAGEMENT LLC454,000$31.6M0.15%Share
30FMR LLC457,859$31.0M0.00%Share
31BlackRock, Inc.385,494$26.0M0.00%Share
32STEMPOINT CAPITAL LP351,073$24.4M4.19%Share
33HSG Holding Ltd254,750$23.4M1.24%Share
34EcoR1 Capital, LLC334,380$23.3M1.06%Share
35FMR LLC279,095$19.0M0.00%Share
36ArrowMark Colorado Holdings LLC271,213$18.9M0.42%Share
37Aberdeen Group plc264,869$18.4M0.03%Share
38NATIONAL BANK OF CANADA /FI/265,400$18.0M0.02%Share
39Catalio Capital Management, LP252,901$17.6M3.11%Share
40Capricorn Fund Managers Ltd252,600$17.6M4.23%Share
41VOLORIDGE INVESTMENT MANAGEMENT, LLC250,000$17.0M0.06%Share
42SUSQUEHANNA INTERNATIONAL GROUP, LLP236,100$16.0M0.00%Call
43Monashee Investment Management LLC225,000$15.6M8.82%Share
44BALYASNY ASSET MANAGEMENT L.P.216,199$15.0M0.02%Share
45MORGAN STANLEY224,422$15.0M0.00%Share
46UBS Group AG202,347$14.1M0.00%Share
47Sio Capital Management, LLC201,500$14.0M2.20%Share
48GOLDMAN SACHS GROUP INC213,684$14.0M0.00%Share
49DIADEMA PARTNERS LP191,700$13.3M2.30%Call
50HighVista Strategies LLC193,001$13.0M3.35%Share

GPCR Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025195$4.5B+63
Q3 2025132$1.5T-12
Q2 2025144$845.9B-7
Q1 2025151$969.5B-9
Q4 2024160$3.6T+22
Q3 2024138$1671.4T-8
Q2 2024146$1363.1T+42
Q1 2024104$1103.7T—

Similar Stocks by Institutional Ownership

LLY

Eli Lilly and Company

JNJ

Johnson & Johnson

ABBV

AbbVie Inc.

NVS

Novartis AG

AZN

AstraZeneca PLC

MRK

Merck & Co., Inc.

UNH

UnitedHealth Group Incorporated

AMGN

Amgen Inc.

As of Q4 2025, 50 institutional investors hold GPCR (Structure Therapeutics Inc.). The largest holder is FMR LLC with $515.0M in shares. This quarter, 14 institutions opened new positions and 2 closed their positions.

Frequently Asked Questions

How many hedge funds own GPCR?

As of Q4 2025, 50 institutional investors report holding GPCR (Structure Therapeutics Inc.) in their 13F filings.

Who is the largest institutional holder of GPCR?

The largest institutional holder of GPCR is FMR LLC with $515.0M in shares.

Is institutional ownership of GPCR increasing or decreasing?

This quarter, 14 institutions opened new positions in GPCR and 2 closed their positions.