DAFNA Capital Management LLC Q4 2025 Filing

Filed February 17, 2026

Portfolio Value

$430.5M

Holdings

77

Report Date

Q4 2025

Filing Type

13F-HR

All Holdings (77 positions)

#StockSharesValue% PortfolioType
1
RVMDREVOLUTION MEDICINES INC
604,514$48.1M11.18%
2
XBISPDR S&P BIOTECH ETF
336,505$41.0M9.53%
3
RJR1STEREOTAXIS INC
13,680,554$31.5M7.31%
4
ATRCATRICURE INC
597,431$23.6M5.49%
5
CYTKCYTOKINETICS INC
370,997$23.6M5.48%
6
IDYAIDEAYA BIOSCIENCES INC
506,740$17.5M4.07%
7
AXGNAXOGEN INC
476,826$15.6M3.62%
8
XENEXENON PHARMACEUTICALS INC
287,939$12.9M3.00%
9
IBBISHARES NASDAQ BIOTECH INDX
68,095$11.5M2.67%
10
BHVNBIOHAVEN LTD
955,235$10.8M2.50%
11
RCUSARCUS BIOSCIENCES INC
431,329$10.3M2.39%
12
NBIXNEUROCRINE BIOSCIENCES INC
70,615$10.0M2.33%
13
DAWNDAY ONE BIOPHARMACEUTICALS I
999,163$9.3M2.16%
14
TNDMTANDEM DIABETES CARE INC
355,208$7.8M1.81%
15
ASNDASCENDIS PHARMA A/S
28,177$6.0M1.40%
16
DC4DEXCOM INC
88,279$5.9M1.36%
17
SNDXSYNDAX PHARMACEUTICALS INC
277,855$5.8M1.36%
18
KALVKALVISTA PHARMACEUTICALS INC
356,802$5.8M1.34%
19
CMPSCOMPASS PATHWAYS PLC
811,046$5.6M1.30%
20
INGNINOGEN INC
827,071$5.6M1.29%
21
ASND 2.25 04/01/28ASCENDIS PHARMA A/S
4,000,000$5.5M1.27%
22
DNLIDENALI THERAPEUTICS INC
318,500$5.3M1.22%
23
MBXMBX BIOSCIENCES INC
165,265$5.2M1.21%
24
BCAXBICARA THERAPEUTICS INC
261,583$4.4M1.02%
25
GLPGGALAPAGOS NV
130,175$4.3M0.99%
26
CATBUSDASTRIA THERAPEUTICS INC
304,775$4.0M0.93%
27
EWTXEDGEWISE THERAPEUTICS INC
159,736$4.0M0.92%
28
IMVTIMMUNOVANT INC
150,524$3.8M0.89%
29
PRCTPROCEPT BIOROBOTICS CORP
120,000$3.8M0.88%
30
HELPCYBIN INC
455,018$3.7M0.86%
31
ALKSALKERMES PLC
130,248$3.6M0.85%
32
LRMRLARIMAR THERAPEUTICS INC
939,164$3.6M0.83%
33
STOKSTOKE THERAPEUTICS INC
108,875$3.5M0.80%
34
LXEOLEXEO THERAPEUTICS INC
340,859$3.4M0.79%
35
BCRXBIOCRYST PHARMACEUTICALS INC
418,255$3.3M0.76%
36
NKTRNEKTAR THERAPEUTICS
74,998$3.2M0.74%
37
PRQRPROQR THERAPEUTICS N V
1,567,561$3.2M0.74%
38
IPSCCENTURY THERAPEUTICS INC
2,793,586$2.8M0.65%
39
IMTXIMMATICS NV
261,138$2.7M0.64%
40
GPCRSTRUCTURE THERAPEUTICS INC
37,000$2.6M0.60%
41
MPLTMAPLIGHT THERAPEUTICS INC
143,764$2.5M0.59%
42
AFWALIGN TECHNOLOGY INC
16,000$2.5M0.58%
43
KURAKURA ONCOLOGY INC
235,868$2.5M0.57%
44
AQSTAQUESTIVE THERAPEUTICS INC
375,915$2.4M0.56%
45
RAPPRAPPORT THERAPEUTICS INC
75,000$2.3M0.53%
46
PRNPROFOUND MEDICAL CORP
285,710$2.2M0.52%
47
SPRYARS PHARMACEUTICALS INC
190,065$2.2M0.51%
48
MDWDMEDIWOUND LTD
113,612$2.1M0.49%
49
VKTXVIKING THERAPEUTICS INC
59,516$2.1M0.49%
50
PODDINSULET CORP
6,870$2.0M0.45%
51
ALLOALLOGENE THERAPEUTICS INC
1,380,118$1.9M0.44%
52
TCE2CELLDEX THERAPEUTICS INC NEW
68,518$1.9M0.43%
53
TELATELA BIO INC
1,441,029$1.7M0.39%
54
ENGNENGENE HOLDINGS INC
163,645$1.5M0.34%
55
VRCAVERRICA PHARMACEUTICALS INC
173,451$1.4M0.33%
56
ALECALECTOR INC
908,351$1.4M0.33%
57
MLYSMINERALYS THERAPEUTICS INC
38,490$1.4M0.32%
58
ANNXANNEXON INC
272,812$1.4M0.32%
59
ORICORIC PHARMACEUTICALS INC
141,045$1.2M0.27%
60
XEJACCURAY INC
1,395,508$1.1M0.27%
61
ERASERASCA INC
254,436$946K0.22%
62
PYPDPOLYPID LTD
207,900$902K0.21%
63
INSPINSPIRE MEDICAL SYSTEMS INC
8,600$793K0.18%
64
ACETADICET BIO INC
93,812$789K0.18%
65
FHTXFOGHORN THERAPEUTICS INC
126,859$685K0.16%
66
BNTXBIONTECH SE
7,000$666K0.15%
67
NGNENEUROGENE INC
27,974$576K0.13%
68
FATEFATE THERAPEUTICS INC
550,000$540K0.13%
69
OBIOORCHESTRA BIOMED HOLDINGS INC
126,841$526K0.12%
70
BCYCBICYCLE THERAPEUTICS PLC
64,492$456K0.11%
71
CGENCOMPUGEN LTD
272,402$416K0.10%
72
KPTIKARYOPHARM THERAPEUTICS
51,000$375K0.09%
73
RAREULTRAGENYX PHARMACEUTICAL INC
16,000$368K0.09%
74
AUTLAUTOLUS THERAPEUTICS PLC
179,316$356K0.08%
75
ADCTADC THERAPEUTICS SA
77,081$272K0.06%
76
BWAYBRAINSWAY LTD
12,965$246K0.06%
77
CATXPERSPECTIVE THERAPEUTICS INC
50,000$137K0.03%