Who Owns Orchestra BioMed Holdings, Inc. (OBIO)?Hedge Fund & Institutional Holders

$4.21-0.17 (-3.77%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$3.44702127856884e+96T

% of Float Held

—

QoQ Change in Holders

+15 / -4

Price History

$2.35$3.44$4.53$5.61$6.70Aug 24Jun 25Mar 26

OBIO — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
683 Capital Management, LLCNew Position+204K+$846K
Holos Integrated Wealth LLCNew Position+103K+$384K
Meramec Financial Planners, LLCNew Position+30K+$117K
Daytona Street Capital LLCNew Position+22K+$89K
Virtu Financial LLCNew Position+14K+$57K
China Universal Asset Management Co., Ltd.New Position+9K+$38K
Mirae Asset Global Investments Co., Ltd.New Position+3K+$11K
GF FUND MANAGEMENT CO. LTD.New Position+1K+$4K
OMERS ADMINISTRATION CorpNew Position+67K+$0
TWO SIGMA INVESTMENTS, LPNew Position+87K+$0
BALYASNY ASSET MANAGEMENT L.P.New Position+18K+$0
CANADA PENSION PLAN INVESTMENT BOARDNew Position+7K+$0
MARSHALL WACE, LLPNew Position+172K+$0
GSA CAPITAL PARTNERS LLPNew Position+11K+$0
Hudson Bay Capital Management LPNew Position+49K+$0

OBIO — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
PERCEPTIVE ADVISORS LLCDecreased-165K-$13.1B
Alyeska Investment Group, L.P.Decreased-365K-$3.4B
Pathstone Holdings, LLCClosed Position-1.0M-$2.5B
Affinity Asset Advisors, LLCDecreased-154K-$1.8B
BlackRock, Inc.Decreased-33K-$1.6B
RENAISSANCE TECHNOLOGIES LLCDecreased-229K-$943.7M
MILLENNIUM MANAGEMENT LLCDecreased-131K-$926.5M
DAFNA Capital Management LLCDecreased-237K-$901.3M
Knoll Capital Management, LLCClosed Position-455K-$421.2M
TD ASSET MANAGEMENT INCDecreased-47K-$229.8M
Cubist Systematic Strategies, LLCClosed Position-78K-$193.2M
LASRY MARCClosed Position-61K-$151.0M
CITADEL ADVISORS LLCDecreased-24K-$133.9M
BANK OF AMERICA CORP /DE/Decreased-14K-$77.2M
Cresset Asset Management, LLCDecreased-10K-$74.4M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1RTW INVESTMENTS, LP8,306,063$34.5M0.35%Share
2PERCEPTIVE ADVISORS LLC5,127,256$21.3M0.38%Share
3VANGUARD GROUP INC1,370,668$5.7M0.00%Share
4Alyeska Investment Group, L.P.1,000,000$4.0M0.01%Share
5Affinity Asset Advisors, LLC572,804$2.4M0.14%Share
6Knott David M Jr250,000$1.0M0.48%Share
7BlackRock, Inc.254,800$1.0M0.00%Share
8MILLENNIUM MANAGEMENT LLC243,473$1.0M0.00%Share
9GEODE CAPITAL MANAGEMENT, LLC387,700$1.0M0.00%Share
10CHARLES SCHWAB INVESTMENT MANAGEMENT INC263,788$1.0M0.00%Share
11PRICE T ROWE ASSOCIATES INC /MD/364,645$1.0M0.00%Share
12VANGUARD GROUP INC219,940$912K0.00%Share
13683 Capital Management, LLC204,076$846K0.04%Share
14DAFNA Capital Management LLC126,841$526K0.12%Share
15Holos Integrated Wealth LLC51,595$222K0.12%Share
16Holos Integrated Wealth LLC51,595$162K0.10%Share
17Meramec Financial Planners, LLC30,000$117K0.05%Share
18Daytona Street Capital LLC21,500$89K0.07%Share
19GROUP ONE TRADING LLC16,900$70K0.00%Call
20Virtu Financial LLC13,623$57K0.00%Share
21VANGUARD GROUP INC13,948$57K0.00%Share
22ABLE Financial Group, LLC13,402$55K0.01%Share
23China Universal Asset Management Co., Ltd.9,201$38K0.00%Share
24UBS Group AG7,124$29K0.00%Share
25UBS Group AG4,265$17K0.00%Share
26Mirae Asset Global Investments Co., Ltd.2,744$11K0.00%Share
27HARBOUR INVESTMENTS, INC.1,988$8K0.00%Share
28GF FUND MANAGEMENT CO. LTD.1,109$4K0.00%Share
29Optiver Holding B.V.312$1K0.00%Share
30AQR CAPITAL MANAGEMENT LLC16,290$00.00%Share
31TWO SIGMA INVESTMENTS, LP86,552$00.00%Share
32BALYASNY ASSET MANAGEMENT L.P.18,268$00.00%Share
33CANADA PENSION PLAN INVESTMENT BOARD7,100$00.00%Share
34CITADEL ADVISORS LLC24,200$00.00%Call
35CITADEL ADVISORS LLC30,175$00.00%Share
36CITADEL ADVISORS LLC16,600$00.00%Put
37SUSQUEHANNA INTERNATIONAL GROUP, LLP155,130$00.00%Share
38TWO SIGMA ADVISERS, LP27,100$00.00%Share
39Tower Research Capital LLC (TRC)646$00.00%Share
40Creative Planning16,290$00.00%Share
41BANK OF AMERICA CORP /DE/6,382$00.00%Share
42BANK OF AMERICA CORP /DE/11,165$00.00%Share
43NORTHERN TRUST CORP110,899$00.00%Share
44OMERS ADMINISTRATION Corp67,100$00.00%Share
45Hudson Bay Capital Management LP49,425$00.00%Share
46Squarepoint Ops LLC44,343$00.00%Share
47TD ASSET MANAGEMENT INC45,692$00.00%Share
48BNP PARIBAS FINANCIAL MARKETS17,007$00.00%Share
49GSA CAPITAL PARTNERS LLP10,773$00.00%Share
50MORGAN STANLEY400$00.00%Share

OBIO Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 202563$77.0M+14
Q3 202549$54.5B-1
Q2 202550$45.5B-5
Q1 202555$79.0B+3
Q4 202452$74.9B+10
Q3 202442$91.4T+1
Q2 202441$90.2T+4
Q1 202437$55.7T—

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As of Q4 2025, 50 institutional investors hold OBIO (Orchestra BioMed Holdings, Inc.). The largest holder is RTW INVESTMENTS, LP with $34.5M in shares. This quarter, 15 institutions opened new positions and 4 closed their positions.

Frequently Asked Questions

How many hedge funds own OBIO?

As of Q4 2025, 50 institutional investors report holding OBIO (Orchestra BioMed Holdings, Inc.) in their 13F filings.

Who is the largest institutional holder of OBIO?

The largest institutional holder of OBIO is RTW INVESTMENTS, LP with $34.5M in shares.

Is institutional ownership of OBIO increasing or decreasing?

This quarter, 15 institutions opened new positions in OBIO and 4 closed their positions.