Who Owns MBX Biosciences, Inc. Common Stock (MBX)?Hedge Fund & Institutional Holders

$27.45-0.50 (-1.79%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

4.553063752292158e+284%

QoQ Change in Holders

+5 / -10

Price History

$5.79$15.13$24.46$33.80$43.14Sep 24Jun 25Mar 26

MBX — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
EVENTIDE ASSET MANAGEMENT, LLCNew Position+890K+$28.1B
D. E. Shaw & Co., Inc.New Position+672K+$21.0B
Point72 Asset Management, L.P.Increased+53K+$10.0B
Soleus Capital Management, L.P.Increased+134K+$8.1B
UBS Group AGIncreased+220K+$7.8B
Goelzer Investment Management, Inc.New Position+222K+$7.0B
Affinity Asset Advisors, LLCIncreased+85K+$5.0B
CHARLES SCHWAB INVESTMENT MANAGEMENT INCIncreased+52K+$4.0B
TWO SIGMA INVESTMENTS, LPIncreased+125K+$3.8B
NORTHERN TRUST CORPIncreased+58K+$2.7B
BALYASNY ASSET MANAGEMENT L.P.Increased+94K+$2.6B
SUSQUEHANNA INTERNATIONAL GROUP, LLPNew Position+77K+$2.0B
OSAIC HOLDINGS, INC.New Position+78K+$2.0B
Nuveen, LLCIncreased+53K+$1.6B
Aaron Wealth Advisors LLCIncreased+20K+$1.3B

MBX — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
FRANKLIN RESOURCES INCClosed Position-1.3M-$22.9B
Kynam Capital Management, LPDecreased-1.1M-$5.5B
Schonfeld Strategic Advisors LLCDecreased-116K-$4.9B
BAKER BROS. ADVISORS LPClosed Position-278K-$4.9B
Longaeva Partners L.P.Closed Position-224K-$3.9B
SECTORAL ASSET MANAGEMENT INCClosed Position-195K-$3.4B
Hudson Bay Capital Management LPClosed Position-85K-$1.5B
Murchinson Ltd.Closed Position-80K-$1.4B
PFM Health Sciences, LPDecreased-142K-$1.4B
Exome Asset Management LLCClosed Position-52K-$917.0M
Ikarian Capital, LLCClosed Position-48K-$841.2M
ExodusPoint Capital Management, LPDecreased-43K-$750.0M
BOOTHBAY FUND MANAGEMENT, LLCClosed Position-39K-$691.2M
XTX Topco LtdDecreased-18K-$671.6M
Ghisallo Capital Management LLCClosed Position-38K-$669.4M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1Frazier Life Sciences Management, L.P.6,652,013$209.8B5.64%Share
2ORBIMED ADVISORS LLC3,935,203$124.1B2.53%Share
3NEA Management Company, LLC3,614,486$114.0B5.81%Share
4WELLINGTON MANAGEMENT GROUP LLP2,845,090$89.0B0.02%Share
5NVP Associates, LLC2,136,335$67.4B26.40%Share
6EcoR1 Capital, LLC2,123,604$67.0B3.04%Share
7DRIEHAUS CAPITAL MANAGEMENT LLC1,408,159$44.4B0.30%Share
8Cormorant Asset Management, LP1,120,000$35.3B1.63%Share
9Woodline Partners LP1,000,063$31.0B0.12%Share
10Kynam Capital Management, LP934,799$29.5B1.88%Share
11EVENTIDE ASSET MANAGEMENT, LLC890,000$28.1B0.44%Share
12CITADEL ADVISORS LLC809,857$25.0B0.00%Share
13D. E. Shaw & Co., Inc.671,838$21.0B0.01%Share
14Point72 Asset Management, L.P.680,609$21.0B0.02%Share
15TCG Crossover Management, LLC650,000$20.5B0.68%Share
16MILLENNIUM MANAGEMENT LLC462,049$14.0B0.01%Share
17WELLINGTON MANAGEMENT GROUP LLP437,672$13.0B0.00%Share
18Soleus Capital Management, L.P.408,900$12.9B0.48%Share
19GOLDMAN SACHS GROUP INC317,404$10.0B0.00%Share
20Rock Springs Capital Management LP282,624$8.9B0.46%Share
21UBS Group AG281,181$8.9B0.00%Share
22Affinity Asset Advisors, LLC250,000$7.9B0.45%Share
23CHARLES SCHWAB INVESTMENT MANAGEMENT INC222,180$7.0B0.00%Share
24SUSQUEHANNA INTERNATIONAL GROUP, LLP228,000$7.0B0.00%Put
25Goelzer Investment Management, Inc.221,672$7.0B0.32%Share
26683 Capital Management, LLC158,800$5.0B0.22%Put
27NORTHERN TRUST CORP186,375$5.0B0.00%Share
28TWO SIGMA INVESTMENTS, LP138,571$4.0B0.01%Share
29Burkehill Global Management, LP100,000$3.2B0.21%Share
30TD ASSET MANAGEMENT INC101,450$3.0B0.00%Share
31BALYASNY ASSET MANAGEMENT L.P.119,726$3.0B0.00%Share
32PFM Health Sciences, LP79,310$2.5B0.25%Share
33STEMPOINT CAPITAL LP78,553$2.5B0.42%Share
34Aaron Wealth Advisors LLC70,000$2.2B0.12%Share
35SCHRODER INVESTMENT MANAGEMENT GROUP73,736$2.0B0.00%Share
36MANUFACTURERS LIFE INSURANCE COMPANY, THE69,551$2.0B0.00%Share
37OSAIC HOLDINGS, INC.77,601$2.0B0.00%Share
38Nuveen, LLC67,908$2.0B0.00%Share
39SUSQUEHANNA INTERNATIONAL GROUP, LLP76,528$2.0B0.00%Share
40SIMPLEX TRADING, LLC44,700$1.0B0.00%Put
41BARCLAYS PLC52,691$1.0B0.00%Share
42RHUMBLINE ADVISERS33,420$1.0B0.00%Share
43PLATINUM INVESTMENT MANAGEMENT LTD43,597$1.0B0.23%Share
44WELLINGTON MANAGEMENT GROUP LLP38,398$1.0B0.00%Share
45RENAISSANCE TECHNOLOGIES LLC32,644$1.0B0.00%Share
46SUSQUEHANNA INTERNATIONAL GROUP, LLP49,900$1.0B0.00%Call
47ExodusPoint Capital Management, LP57,005$1.0B0.01%Share
48ALPS ADVISORS INC36,872$1.0B0.01%Share
49WELLS FARGO & COMPANY/MN31,931$1.0B0.00%Share
50Caption Management, LLC25,100$791.0M0.01%Call

MBX Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025136$1.1T+30
Q3 2025106$659.0B+31
Q2 202575$270.7B-4
Q1 202579$211.7B+17
Q4 202462$490.3B+22
Q3 202440$81.0T—

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As of Q4 2025, 50 institutional investors hold MBX (MBX Biosciences, Inc. Common Stock). The largest holder is Frazier Life Sciences Management, L.P. with $209.8B in shares. This quarter, 5 institutions opened new positions and 10 closed their positions.

Frequently Asked Questions

How many hedge funds own MBX?

As of Q4 2025, 50 institutional investors report holding MBX (MBX Biosciences, Inc. Common Stock) in their 13F filings.

Who is the largest institutional holder of MBX?

The largest institutional holder of MBX is Frazier Life Sciences Management, L.P. with $209.8B in shares.

Is institutional ownership of MBX increasing or decreasing?

This quarter, 5 institutions opened new positions in MBX and 10 closed their positions.