DAFNA Capital Management LLC
CIK: 0001389933Latest portfolio: $430.5M · Q4 2025
Holdings
77
Total Value
$430.5M
New Positions
12
Closed Positions
10
Top Holdings
View All 77 Holdings →| # | Stock | Shares | Value | % Portfolio | Change | Type |
|---|---|---|---|---|---|---|
| 1 | RVMDREVOLUTION MEDICINES INC | 604,514 | $48.1M | 11.18% | -52,662 | |
| 2 | XBISPDR S&P BIOTECH ETF | 336,505 | $41.0M | 9.53% | -65,000 | |
| 3 | RJR1STEREOTAXIS INC | 13,680,554 | $31.5M | 7.31% | — | |
| 4 | ATRCATRICURE INC | 597,431 | $23.6M | 5.49% | +5K | |
| 5 | CYTKCYTOKINETICS INC | 370,997 | $23.6M | 5.48% | -23,943 | |
| 6 | IDYAIDEAYA BIOSCIENCES INC | 506,740 | $17.5M | 4.07% | -33,183 | |
| 7 | AXGNAXOGEN INC | 476,826 | $15.6M | 3.62% | -265,456 | |
| 8 | XENEXENON PHARMACEUTICALS INC | 287,939 | $12.9M | 3.00% | — | |
| 9 | IBBISHARES NASDAQ BIOTECH INDX | 68,095 | $11.5M | 2.67% | -34,405 | |
| 10 | BHVNBIOHAVEN LTD | 955,235 | $10.8M | 2.50% | +720K | |
| 11 | RCUSARCUS BIOSCIENCES INC | 431,329 | $10.3M | 2.39% | -196,297 | |
| 12 | NBIXNEUROCRINE BIOSCIENCES INC | 70,615 | $10.0M | 2.33% | — | |
| 13 | DAWNDAY ONE BIOPHARMACEUTICALS I | 999,163 | $9.3M | 2.16% | — | |
| 14 | TNDMTANDEM DIABETES CARE INC | 355,208 | $7.8M | 1.81% | — | |
| 15 | ASNDASCENDIS PHARMA A/S | 28,177 | $6.0M | 1.40% | -5,000 | |
| 16 | DC4DEXCOM INC | 88,279 | $5.9M | 1.36% | +23K | |
| 17 | SNDXSYNDAX PHARMACEUTICALS INC | 277,855 | $5.8M | 1.36% | -222,847 | |
| 18 | KALVKALVISTA PHARMACEUTICALS INC | 356,802 | $5.8M | 1.34% | -65,929 | |
| 19 | CMPSCOMPASS PATHWAYS PLC | 811,046 | $5.6M | 1.30% | — | |
| 20 | INGNINOGEN INC | 827,071 | $5.6M | 1.29% | +221K | |
| 21 | ASND 2.25 04/01/28ASCENDIS PHARMA A/S | 4,000,000 | $5.5M | 1.27% | — | |
| 22 | DNLIDENALI THERAPEUTICS INC | 318,500 | $5.3M | 1.22% | +150K | |
| 23 | MBXMBX BIOSCIENCES INC | 165,265 | $5.2M | 1.21% | +80K | |
| 24 | BCAXBICARA THERAPEUTICS INC | 261,583 | $4.4M | 1.02% | -55,418 | |
| 25 | GLPGGALAPAGOS NV | 130,175 | $4.3M | 0.99% | — |
Quarterly Changes
New Positions
Increased Positions
Sector Breakdown
Healthcare0.0% ($4.814923634235732e+250T)
Unknown0.0% ($31465585954603991040.0T)
Financial Services0.0% ($41030.1T)
Filing History
Fund Information
DAFNA Capital Management LLC is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $430.5M across 77 holdings. The largest position is REVOLUTION MEDICINES INC (RVMD), representing 11.2% of the portfolio. Compared to the previous quarter, the fund opened 12 new positions and closed 10 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.