| 1 | VANGUARD GROUP INC | 2,742,447 | $252.9M | 0.00% | Share |
| 2 | BlackRock, Inc. | 2,478,164 | $228.0M | 0.00% | Share |
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,002,529 | $184.0M | 0.03% | Share |
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,505,872 | $138.9M | 1.77% | Share |
| 5 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,161,285 | $107.1M | 0.30% | Share |
| 6 | STATE STREET CORP | 918,504 | $84.0M | 0.00% | Share |
| 7 | D. E. Shaw & Co., Inc. | 846,547 | $78.0M | 0.04% | Share |
| 8 | Artisan Partners Limited Partnership | 785,742 | $72.0M | 0.11% | Share |
| 9 | BlackRock, Inc. | 707,557 | $65.0M | 0.00% | Share |
| 10 | MORGAN STANLEY | 682,353 | $62.0M | 0.00% | Share |
| 11 | FULLER & THALER ASSET MANAGEMENT, INC. | 668,099 | $61.0M | 0.21% | Share |
| 12 | BRAIDWELL LP | 540,890 | $49.9M | 1.60% | Share |
| 13 | JANUS HENDERSON GROUP PLC | 519,328 | $47.0M | 0.02% | Share |
| 14 | DEUTSCHE BANK AG\ | 510,941 | $47.0M | 0.02% | Share |
| 15 | Aberdeen Group plc | 460,901 | $42.5M | 0.07% | Share |
| 16 | MARSHALL WACE, LLP | 447,345 | $41.0M | 0.04% | Share |
| 17 | BNP PARIBAS FINANCIAL MARKETS | 454,810 | $41.0M | 0.02% | Share |
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 440,205 | $40.6M | 0.63% | Share |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 427,488 | $39.0M | 0.00% | Share |
| 20 | RENAISSANCE TECHNOLOGIES LLC | 410,768 | $37.0M | 0.06% | Share |
| 21 | UBS Group AG | 390,076 | $36.0M | 0.01% | Share |
| 22 | Amundi | 364,622 | $33.0M | 0.01% | Share |
| 23 | D. E. Shaw & Co., Inc. | 365,615 | $33.0M | 0.02% | Share |
| 24 | DRIEHAUS CAPITAL MANAGEMENT LLC | 348,500 | $32.1M | 0.22% | Share |
| 25 | BAMCO INC /NY/ | 337,486 | $31.1M | 0.08% | Share |
| 26 | CITADEL ADVISORS LLC | 336,773 | $31.0M | 0.00% | Share |
| 27 | DIMENSIONAL FUND ADVISORS LP | 316,429 | $29.0M | 0.01% | Share |
| 28 | Jefferies Financial Group Inc. | 307,588 | $28.0M | 0.14% | Share |
| 29 | Soleus Capital Management, L.P. | 299,399 | $27.6M | 1.02% | Share |
| 30 | PRICE T ROWE ASSOCIATES INC /MD/ | 283,466 | $26.0M | 0.00% | Share |
| 31 | Assenagon Asset Management S.A. | 264,999 | $24.4M | 0.03% | Share |
| 32 | Jain Global LLC | 268,250 | $24.0M | 0.12% | Share |
| 33 | MORGAN STANLEY | 258,155 | $23.0M | 0.00% | Share |
| 34 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 230,761 | $21.0M | 0.00% | Share |
| 35 | Trexquant Investment LP | 213,249 | $19.7M | 0.18% | Share |
| 36 | FRANKLIN RESOURCES INC | 207,290 | $19.0M | 0.00% | Share |
| 37 | Champlain Investment Partners, LLC | 203,098 | $18.7M | 0.19% | Share |
| 38 | KEYBANK NATIONAL ASSOCIATION/OH | 200,042 | $18.4M | 0.07% | Share |
| 39 | MILLENNIUM MANAGEMENT LLC | 202,140 | $18.0M | 0.01% | Share |
| 40 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 198,368 | $18.0M | 0.00% | Share |
| 41 | Regal Partners Ltd | 185,038 | $17.1M | 0.98% | Share |
| 42 | BALYASNY ASSET MANAGEMENT L.P. | 187,226 | $17.0M | 0.02% | Share |
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 194,155 | $17.0M | 0.00% | Share |
| 44 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 188,100 | $17.0M | 0.06% | Share |
| 45 | CITADEL ADVISORS LLC | 174,545 | $16.0M | 0.00% | Share |
| 46 | VANGUARD GROUP INC | 167,838 | $15.5M | 0.00% | Share |
| 47 | MORGAN STANLEY | 160,599 | $14.0M | 0.00% | Share |
| 48 | FRONTIER CAPITAL MANAGEMENT CO LLC | 142,007 | $13.1M | 0.14% | Share |
| 49 | RA CAPITAL MANAGEMENT, L.P. | 141,964 | $13.1M | 0.13% | Share |
| 50 | GOLDMAN SACHS GROUP INC | 141,327 | $13.0M | 0.00% | Share |