| 1 | ORBIMED ADVISORS LLC | 1,027,944 | $8.7M | 0.18% | Share |
| 2 | RA CAPITAL MANAGEMENT, L.P. | 948,249 | $8.0M | 0.08% | Share |
| 3 | FRANKLIN RESOURCES INC | 626,571 | $5.0M | 0.00% | Share |
| 4 | Woodline Partners LP | 625,000 | $5.0M | 0.02% | Share |
| 5 | Prosight Management, LP | 250,244 | $2.1M | 0.44% | Share |
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 274,375 | $2.0M | 0.00% | Share |
| 7 | RENAISSANCE TECHNOLOGIES LLC | 242,945 | $2.0M | 0.00% | Share |
| 8 | VANGUARD GROUP INC | 235,722 | $2.0M | 0.00% | Share |
| 9 | Stonepine Capital Management, LLC | 220,011 | $1.9M | 1.35% | Share |
| 10 | Carlyle Group Inc. | 184,295 | $1.5M | 0.01% | Share |
| 11 | NEXTBio Capital Management LP | 157,827 | $1.3M | 0.78% | Share |
| 12 | ADAR1 Capital Management, LLC | 128,646 | $1.1M | 0.08% | Share |
| 13 | ACADIAN ASSET MANAGEMENT LLC | 181,395 | $1.0M | 0.00% | Share |
| 14 | TWO SIGMA INVESTMENTS, LP | 144,796 | $1.0M | 0.00% | Share |
| 15 | GOLDMAN SACHS GROUP INC | 234,510 | $1.0M | 0.00% | Share |
| 16 | Alyeska Investment Group, L.P. | 203,799 | $1.0M | 0.00% | Share |
| 17 | DAFNA Capital Management LLC | 93,812 | $789K | 0.18% | Share |
| 18 | Burkehill Global Management, LP | 62,500 | $526K | 0.03% | Share |
| 19 | LUMINUS MANAGEMENT LLC | 59,558 | $501K | 0.44% | Share |
| 20 | VANGUARD GROUP INC | 50,334 | $423K | 0.00% | Share |
| 21 | Maven Securities LTD | 31,250 | $263K | 0.01% | Share |
| 22 | Rangeley Capital, LLC | 25,001 | $210K | 0.17% | Share |
| 23 | JOHNSON & JOHNSON | 22,779 | $191K | 0.03% | Share |
| 24 | FNY Investment Advisers, LLC | 6,100 | $51K | 0.01% | Share |
| 25 | TANG CAPITAL MANAGEMENT LLC | 6,158 | $51K | 0.00% | Share |
| 26 | VANGUARD GROUP INC | 5,221 | $43K | 0.00% | Share |
| 27 | UBS Group AG | 2,844 | $23K | 0.00% | Share |
| 28 | UBS Group AG | 953 | $8K | 0.00% | Share |
| 29 | JPMORGAN CHASE & CO | 8 | $0 | 0.00% | Share |
| 30 | SBI Securities Co., Ltd. | 19 | $0 | 0.00% | Share |
| 31 | GSA CAPITAL PARTNERS LLP | 17,763 | $0 | 0.00% | Share |
| 32 | SIMPLEX TRADING, LLC | 1,700 | $0 | 0.00% | Call |
| 33 | SIMPLEX TRADING, LLC | 87 | $0 | 0.00% | Share |
| 34 | SIMPLEX TRADING, LLC | 400 | $0 | 0.00% | Put |
| 35 | XTX Topco Ltd | 18,610 | $0 | 0.00% | Share |
| 36 | BARCLAYS PLC | 25,000 | $0 | 0.00% | Share |
| 37 | STATE STREET CORP | 25,896 | $0 | 0.00% | Share |
| 38 | HOLLENCREST CAPITAL MANAGEMENT | 250 | $0 | 0.00% | Share |
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 64,699 | $0 | 0.00% | Share |
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 24,157 | $0 | 0.00% | Share |
| 41 | ROYAL BANK OF CANADA | 5,437 | $0 | 0.00% | Share |
| 42 | ROYAL BANK OF CANADA | 12 | $0 | 0.00% | Share |
| 43 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56,350 | $0 | 0.00% | Share |
| 44 | RBF Capital, LLC | 38,582 | $0 | 0.00% | Share |
| 45 | CITADEL ADVISORS LLC | 107,814 | $0 | 0.00% | Share |
| 46 | TWO SIGMA ADVISERS, LP | 111,336 | $0 | 0.00% | Share |
| 47 | Tower Research Capital LLC (TRC) | 1,072 | $0 | 0.00% | Share |
| 48 | FMR LLC | 34 | $0 | 0.00% | Share |
| 49 | BANK OF AMERICA CORP /DE/ | 1,275 | $0 | 0.00% | Share |
| 50 | BANK OF AMERICA CORP /DE/ | 8 | $0 | 0.00% | Share |