| 1 | ARMISTICE CAPITAL, LLC | 1,118,925 | $9.3M | 0.11% | Share |
| 2 | Caligan Partners LP | 923,910 | $7.7M | 0.63% | Share |
| 3 | Affinity Asset Advisors, LLC | 707,338 | $5.9M | 0.33% | Share |
| 4 | Velan Capital Investment Management LP | 471,559 | $3.9M | 2.27% | Share |
| 5 | Stonepine Capital Management, LLC | 353,669 | $2.9M | 2.14% | Share |
| 6 | BOOTHBAY FUND MANAGEMENT, LLC | 280,734 | $2.0M | 0.03% | Share |
| 7 | Kalehua Capital Management LLC | 235,779 | $2.0M | 1.94% | Share |
| 8 | DAFNA Capital Management LLC | 173,451 | $1.4M | 0.33% | Share |
| 9 | VANGUARD GROUP INC | 110,606 | $919K | 0.00% | Share |
| 10 | Sovran Advisors, LLC | 32,658 | $248K | 0.02% | Share |
| 11 | VANGUARD GROUP INC | 26,726 | $222K | 0.00% | Share |
| 12 | Legacy Trust | 17,234 | $143K | 0.03% | Share |
| 13 | BECK MACK & OLIVER LLC | 12,000 | $99K | 0.00% | Share |
| 14 | Capital Analysts, LLC | 1,500 | $12K | 0.00% | Share |
| 15 | VANGUARD GROUP INC | 862 | $7K | 0.00% | Share |
| 16 | Fortitude Family Office, LLC | 608 | $5K | 0.00% | Share |
| 17 | Salomon & Ludwin, LLC | 290 | $2K | 0.00% | Share |
| 18 | New England Capital Financial Advisors LLC | 200 | $1K | 0.00% | Share |
| 19 | INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 175 | $1K | 0.00% | Share |
| 20 | STATE STREET CORP | 23,481 | $0 | 0.00% | Share |
| 21 | RENAISSANCE TECHNOLOGIES LLC | 26,400 | $0 | 0.00% | Share |
| 22 | JANE STREET GROUP, LLC | 75,035 | $0 | 0.00% | Share |
| 23 | JANE STREET GROUP, LLC | 6 | $0 | 0.00% | Share |
| 24 | JANE STREET GROUP, LLC | 26,681 | $0 | 0.00% | Share |
| 25 | Covestor Ltd | 54 | $0 | 0.00% | Share |
| 26 | GOLDMAN SACHS GROUP INC | 18,621 | $0 | 0.00% | Share |
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 12,697 | $0 | 0.00% | Share |
| 28 | TWO SIGMA INVESTMENTS, LP | 118,218 | $0 | 0.00% | Share |
| 29 | MILLENNIUM MANAGEMENT LLC | 23,123 | $0 | 0.00% | Share |
| 30 | BANK OF AMERICA CORP /DE/ | 4,337 | $0 | 0.00% | Share |
| 31 | BANK OF AMERICA CORP /DE/ | 6 | $0 | 0.00% | Share |
| 32 | MAI Capital Management | 2 | $0 | 0.00% | Share |
| 33 | OMERS ADMINISTRATION Corp | 22,600 | $0 | 0.00% | Share |
| 34 | Walleye Capital LLC | 15,240 | $0 | 0.00% | Share |
| 35 | BNP PARIBAS FINANCIAL MARKETS | 110 | $0 | 0.00% | Share |
| 36 | MORGAN STANLEY | 22,008 | $0 | 0.00% | Share |
| 37 | JPMORGAN CHASE & CO | 47 | $0 | 0.00% | Share |
| 38 | XTX Topco Ltd | 14,662 | $0 | 0.00% | Share |
| 39 | Man Group plc | 11,287 | $0 | 0.00% | Share |
| 40 | HRT FINANCIAL LP | 17,356 | $0 | 0.00% | Share |
| 41 | UBS Group AG | 24 | $0 | 0.00% | Share |
| 42 | GROUP ONE TRADING LLC | 3 | $0 | 0.00% | Share |
| 43 | Quadrature Capital Ltd | 11,954 | $0 | 0.00% | Share |
| 44 | BARCLAYS PLC | 1 | $0 | 0.00% | Share |
| 45 | ROYAL BANK OF CANADA | 7 | $0 | 0.00% | Share |
| 46 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 12,000 | $0 | 0.00% | Share |
| 47 | TWO SIGMA ADVISERS, LP | 44,430 | $0 | 0.00% | Share |
| 48 | Tower Research Capital LLC (TRC) | 3,342 | $0 | 0.00% | Share |
| 49 | ROYAL BANK OF CANADA | 409 | $0 | 0.00% | Share |
| 50 | NORTHERN TRUST CORP | 19,244 | $0 | 0.00% | Share |