| 1 | BVF INC/IL | 1,559,595 | $65.9M | 2.22% | Share |
| 2 | VANGUARD GROUP INC | 883,951 | $37.4M | 0.00% | Share |
| 3 | Two Seas Capital LP | 745,185 | $31.5M | 0.65% | Share |
| 4 | ARMISTICE CAPITAL, LLC | 596,000 | $25.2M | 0.30% | Share |
| 5 | Prosight Management, LP | 554,633 | $23.4M | 4.85% | Share |
| 6 | TWO SIGMA INVESTMENTS, LP | 473,014 | $19.0M | 0.03% | Share |
| 7 | MILLENNIUM MANAGEMENT LLC | 454,075 | $19.0M | 0.01% | Share |
| 8 | Sofinnova Investments, Inc. | 438,630 | $18.5M | 0.80% | Share |
| 9 | Point72 Asset Management, L.P. | 433,419 | $18.0M | 0.02% | Share |
| 10 | Invesco Ltd. | 402,750 | $17.0M | 0.00% | Share |
| 11 | BlackRock, Inc. | 413,934 | $17.0M | 0.00% | Share |
| 12 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 410,600 | $17.0M | 0.00% | Call |
| 13 | EMERALD ADVISERS, LLC | 384,342 | $16.2M | 0.50% | Share |
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 374,537 | $15.0M | 0.00% | Share |
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 364,400 | $15.0M | 0.00% | Put |
| 16 | MORGAN STANLEY | 358,140 | $15.0M | 0.00% | Share |
| 17 | TWO SIGMA ADVISERS, LP | 308,414 | $13.0M | 0.03% | Share |
| 18 | Qube Research & Technologies Ltd | 323,915 | $13.0M | 0.01% | Share |
| 19 | UBS Group AG | 287,171 | $12.1M | 0.00% | Share |
| 20 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 295,716 | $12.0M | 0.04% | Share |
| 21 | PRIMECAP MANAGEMENT CO/CA/ | 280,150 | $11.8M | 0.01% | Share |
| 22 | BALYASNY ASSET MANAGEMENT L.P. | 282,021 | $11.0M | 0.01% | Share |
| 23 | EMERALD MUTUAL FUND ADVISERS TRUST | 253,125 | $10.7M | 0.52% | Share |
| 24 | GREAT POINT PARTNERS LLC | 210,732 | $8.9M | 2.89% | Share |
| 25 | GILDER GAGNON HOWE & CO LLC | 208,302 | $8.8M | 0.09% | Share |
| 26 | BNP PARIBAS FINANCIAL MARKETS | 210,298 | $8.0M | 0.00% | Share |
| 27 | STATE STREET CORP | 195,656 | $8.0M | 0.00% | Share |
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 211,070 | $8.0M | 0.00% | Share |
| 29 | Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 188,112 | $8.0M | 0.71% | Share |
| 30 | Creek Drive Management Group LLC | 185,500 | $7.8M | 5.84% | Share |
| 31 | STEMPOINT CAPITAL LP | 178,274 | $7.5M | 1.29% | Share |
| 32 | CITADEL ADVISORS LLC | 181,641 | $7.0M | 0.00% | Share |
| 33 | HRT FINANCIAL LP | 173,443 | $7.0M | 0.02% | Share |
| 34 | RENAISSANCE TECHNOLOGIES LLC | 172,881 | $7.0M | 0.01% | Share |
| 35 | MORGAN STANLEY | 163,063 | $6.0M | 0.00% | Share |
| 36 | JANE STREET GROUP, LLC | 155,574 | $6.0M | 0.00% | Share |
| 37 | GOLDMAN SACHS GROUP INC | 142,290 | $6.0M | 0.00% | Share |
| 38 | GROUP ONE TRADING LLC | 138,200 | $5.8M | 0.01% | Call |
| 39 | VANGUARD GROUP INC | 120,255 | $5.1M | 0.00% | Share |
| 40 | CITADEL ADVISORS LLC | 128,136 | $5.0M | 0.00% | Share |
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,380 | $5.0M | 0.00% | Share |
| 42 | Nantahala Capital Management, LLC | 112,946 | $4.8M | 0.16% | Share |
| 43 | Woodline Partners LP | 104,000 | $4.0M | 0.02% | Share |
| 44 | Connor, Clark & Lunn Investment Management Ltd. | 101,166 | $4.0M | 0.01% | Share |
| 45 | JPMORGAN CHASE & CO | 107,504 | $4.0M | 0.00% | Share |
| 46 | ING GROEP NV | 100,000 | $4.0M | 0.02% | Share |
| 47 | Jefferies Financial Group Inc. | 111,900 | $4.0M | 0.02% | Share |
| 48 | Monashee Investment Management LLC | 94,134 | $4.0M | 2.24% | Share |
| 49 | Quinn Opportunity Partners LLC | 85,868 | $3.6M | 0.15% | Share |
| 50 | Stonepine Capital Management, LLC | 85,000 | $3.6M | 2.62% | Share |