| 1 | Syncona Portfolio Ltd | 1,213,056 | $1.2B | 3.52% | Share |
| 2 | Point72 Asset Management, L.P. | 5,961,631 | $5.0M | 0.01% | Share |
| 3 | DAFNA Capital Management LLC | 2,793,586 | $2.8M | 0.65% | Share |
| 4 | VANGUARD GROUP INC | 1,826,165 | $1.8M | 0.00% | Share |
| 5 | Spruce Street Capital LP | 1,421,532 | $1.4M | 0.47% | Share |
| 6 | Casdin Capital, LLC | 1,228,190 | $1.2M | 0.08% | Share |
| 7 | ACADIAN ASSET MANAGEMENT LLC | 1,217,103 | $1.0M | 0.00% | Share |
| 8 | RENAISSANCE TECHNOLOGIES LLC | 1,349,200 | $1.0M | 0.00% | Share |
| 9 | TWO SIGMA ADVISERS, LP | 1,267,700 | $1.0M | 0.00% | Share |
| 10 | TWO SIGMA INVESTMENTS, LP | 1,495,916 | $1.0M | 0.00% | Share |
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,838,700 | $1.0M | 0.00% | Share |
| 12 | SUPERSTRING CAPITAL MANAGEMENT LP | 462,963 | $460K | 0.25% | Share |
| 13 | VANGUARD GROUP INC | 267,814 | $266K | 0.00% | Share |
| 14 | UBS Group AG | 214,501 | $213K | 0.00% | Share |
| 15 | WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 77,797 | $70K | 0.00% | Share |
| 16 | HARBOURVEST PARTNERS LLC | 29,018 | $28K | 0.02% | Share |
| 17 | Parametrica Management Ltd | 27,840 | $27K | 0.04% | Share |
| 18 | Quadrant Private Wealth Management, LLC | 15,286 | $15K | 0.00% | Share |
| 19 | Scientech Research LLC | 12,355 | $12K | 0.01% | Share |
| 20 | VANGUARD GROUP INC | 9,890 | $9K | 0.00% | Share |
| 21 | SBI Securities Co., Ltd. | 1,530 | $1K | 0.00% | Share |
| 22 | FMR LLC | 71,540 | $0 | 0.00% | Share |
| 23 | NORTHERN TRUST CORP | 105,052 | $0 | 0.00% | Share |
| 24 | Smartleaf Asset Management LLC | 1 | $0 | 0.00% | Share |
| 25 | CITADEL ADVISORS LLC | 319,457 | $0 | 0.00% | Share |
| 26 | BlackRock, Inc. | 2,210 | $0 | 0.00% | Share |
| 27 | BlackRock, Inc. | 599,656 | $0 | 0.00% | Share |
| 28 | ALGERT GLOBAL LLC | 76,800 | $0 | 0.00% | Share |
| 29 | JANE STREET GROUP, LLC | 45,194 | $0 | 0.00% | Share |
| 30 | MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | $0 | 0.00% | Share |
| 31 | Advisors Asset Management, Inc. | 8,313 | $0 | 0.00% | Share |
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 379,097 | $0 | 0.00% | Share |
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 77,018 | $0 | 0.00% | Share |
| 34 | PRUDENTIAL FINANCIAL INC | 59,800 | $0 | 0.00% | Share |
| 35 | RAYMOND JAMES FINANCIAL INC | 91,323 | $0 | 0.00% | Share |
| 36 | ROYAL BANK OF CANADA | 69 | $0 | 0.00% | Share |
| 37 | WELLS FARGO & COMPANY/MN | 40 | $0 | 0.00% | Share |
| 38 | MILLENNIUM MANAGEMENT LLC | 610,387 | $0 | 0.00% | Share |
| 39 | SIMPLEX TRADING, LLC | 2,397 | $0 | 0.00% | Share |
| 40 | NISA INVESTMENT ADVISORS, LLC | 883 | $0 | 0.00% | Share |
| 41 | BANK OF AMERICA CORP /DE/ | 475 | $0 | 0.00% | Share |
| 42 | BANK OF AMERICA CORP /DE/ | 50 | $0 | 0.00% | Share |
| 43 | Arax Advisory Partners | 99 | $0 | 0.00% | Share |
| 44 | BNP PARIBAS FINANCIAL MARKETS | 1,447 | $0 | 0.00% | Share |
| 45 | GSA CAPITAL PARTNERS LLP | 333,199 | $0 | 0.00% | Share |
| 46 | JPMORGAN CHASE & CO | 1,662 | $0 | 0.00% | Share |
| 47 | JPMORGAN CHASE & CO | 1,415 | $0 | 0.00% | Share |
| 48 | Optiver Holding B.V. | 32 | $0 | 0.00% | Share |
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,104 | $0 | 0.00% | Share |
| 50 | SIMPLEX TRADING, LLC | 1,900 | $0 | 0.00% | Put |