RA CAPITAL MANAGEMENT, L.P. Q4 2025 Filing
Filed February 17, 2026
Portfolio Value
$9.8B
Holdings
71
Report Date
Q4 2025
Filing Type
13F-HR
All Holdings (71 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | ASNDASCENDIS PHARMA A/S - ADR | 10,281,496 | $2.2B | 22.46% | |
| 2 | CDTXCIDARA THERAPEUTICS INC | 3,365,523 | $743.4M | 7.62% | |
| 3 | RYTMRHYTHM PHARMACEUTICALS INC | 6,666,837 | $713.6M | 7.31% | |
| 4 | RNAAVIDITY BIOSCIENCES INC | 8,641,031 | $623.3M | 6.39% | |
| 5 | PCVXVAXCYTE INC | 10,724,599 | $494.8M | 5.07% | |
| 6 | SIONSIONNA THERAPEUTICS INC | 9,905,045 | $407.5M | 4.17% | |
| 7 | NAMSNEWAMSTERDAM PHARMA CO NV | 9,550,191 | $335.0M | 3.43% | |
| 8 | TYRATYRA BIOSCIENCES INC | 12,198,625 | $320.7M | 3.29% | |
| 9 | WVEWAVE LIFE SCIENCES LTD | 18,203,009 | $309.5M | 3.17% | |
| 10 | MLYSMINERALYS THERAPEUTICS INC | 7,323,750 | $265.8M | 2.72% | |
| 11 | EWTXEDGEWISE THERAPEUTICS INC | 10,428,437 | $258.8M | 2.65% | |
| 12 | SEPNSEPTERNA INC | 6,995,858 | $195.0M | 2.00% | |
| 13 | NUVLNUVALENT INC-A | 1,880,057 | $189.1M | 1.94% | |
| 14 | IRONDISC MEDICINE INC | 1,976,132 | $156.9M | 1.61% | |
| 15 | JANXJANUX THERAPEUTICS INC | 11,189,693 | $154.4M | 1.58% | |
| 16 | PEPGPEPGEN INC | 20,064,545 | $130.6M | 1.34% | |
| 17 | TSHATAYSHA GENE THERAPIES INC | 23,555,648 | $129.6M | 1.33% | |
| 18 | SPRYARS PHARMACEUTICALS INC | 10,860,977 | $126.5M | 1.30% | |
| 19 | BCRXBIOCRYST PHARMACEUTICALS INC | 15,827,186 | $123.5M | 1.26% | |
| 20 | BCAXBICARA THERAPEUTICS INC | 6,955,993 | $117.1M | 1.20% | |
| 21 | PRAXPRAXIS PRECISION MEDICINES I | 373,787 | $110.2M | 1.13% | |
| 22 | GHRSGH RESEARCH PLC | 7,676,697 | $97.5M | 1.00% | |
| 23 | GONGERON CORP | 63,771,366 | $84.2M | 0.86% | |
| 24 | ACLXARCELLX INC | 1,267,156 | $82.6M | 0.85% | |
| 25 | CLYMCLIMB BIO INC | 11,293,828 | $77.7M | 0.80% | |
| 26 | VORVOR BIOPHARMA INC | 5,404,998 | $70.7M | 0.72% | |
| 27 | BLTEBELITE BIO INC - ADR | 432,484 | $69.2M | 0.71% | |
| 28 | FULCFULCRUM THERAPEUTICS INC | 6,053,960 | $68.5M | 0.70% | |
| 29 | LENZLENZ THERAPEUTICS INC | 4,178,823 | $66.9M | 0.68% | |
| 30 | DNTHDIANTHUS THERAPEUTICS INC | 1,611,733 | $66.4M | 0.68% | |
| 31 | OLMAOLEMA PHARMACEUTICALS INC | 2,600,000 | $65.0M | 0.67% | |
| 32 | EVMNEVOMMUNE INC | 3,458,770 | $59.2M | 0.61% | |
| 33 | JBIOJADE BIOSCIENCES INC | 3,671,083 | $56.6M | 0.58% | |
| 34 | SYRESPYRE THERAPEUTICS INC | 1,621,620 | $53.1M | 0.54% | |
| 35 | LXEOLEXEO THERAPEUTICS INC | 5,000,000 | $49.6M | 0.51% | |
| 36 | LBRXLB PHARMACEUTICALS INC | 2,208,604 | $49.2M | 0.50% | |
| 37 | MNPRMONOPAR THERAPEUTICS INC | 667,207 | $43.6M | 0.45% | |
| 38 | CAPRCAPRICOR THERAPEUTICS INC | 1,507,844 | $43.5M | 0.45% | |
| 39 | FDMT4D MOLECULAR THERAPEUTICS IN | 5,653,211 | $42.4M | 0.43% | |
| 40 | IVVDINVIVYD INC | 17,119,096 | $42.3M | 0.43% | |
| 41 | ARTVARTIVA BIOTHERAPEUTICS INC | 9,853,302 | $42.3M | 0.43% | |
| 42 | GRALGRAIL INC | 428,266 | $36.7M | 0.38% | |
| 43 | ASMBASSEMBLY BIOSCIENCES INC | 1,020,410 | $34.7M | 0.36% | |
| 44 | SLDBSOLID BIOSCIENCES INC | 5,811,423 | $32.8M | 0.34% | |
| 45 | ABOSACUMEN PHARMACEUTICALS INC | 14,932,063 | $31.5M | 0.32% | |
| 46 | BNTCBENITEC BIOPHARMA INC | 1,850,000 | $24.9M | 0.26% | |
| 47 | CTNMCONTINEUM THERAPEUTICS INC-A | 2,179,711 | $24.9M | 0.26% | |
| 48 | RZLTREZOLUTE INC | 9,180,000 | $21.7M | 0.22% | |
| 49 | ACRVACRIVON THERAPEUTICS INC | 8,340,508 | $20.1M | 0.21% | |
| 50 | NKTXNKARTA INC | 10,805,129 | $20.0M | 0.20% | |
| 51 | OVIDOVID THERAPEUTICS INC | 10,714,000 | $17.5M | 0.18% | |
| 52 | PALIPALISADE BIO INC | 7,124,116 | $16.7M | 0.17% | |
| 53 | SABSSAB BIOTHERAPEUTICS INC | 4,401,500 | $16.5M | 0.17% | |
| 54 | CCCCC4 THERAPEUTICS INC | 8,000,000 | $15.3M | 0.16% | |
| 55 | MDLNMEDLINE INC-CL A | 335,000 | $14.1M | 0.14% | |
| 56 | DSGNDESIGN THERAPEUTICS INC | 1,461,381 | $13.7M | 0.14% | |
| 57 | INSPINSPIRE MEDICAL SYSTEMS INC | 141,964 | $13.1M | 0.13% | |
| 58 | AVTXAVALO THERAPEUTICS INC | 662,968 | $12.0M | 0.12% | |
| 59 | RANIRANI THERAPEUTICS HOLDINGS-A | 8,500,000 | $11.5M | 0.12% | |
| 60 | —PERCEPTIVE CAPITAL SOLUTIONS | 750,000 | $9.8M | 0.10% | |
| 61 | ACETADICET BIO INC | 948,249 | $8.0M | 0.08% | |
| 62 | NAMSNEWAMSTERDAM PHARMA CO NV-27 | 333,333 | $7.7M | 0.08% | |
| 63 | WGSGENEDX HOLDINGS CORP | 58,044 | $7.5M | 0.08% | |
| 64 | WAYWAYSTAR HOLDING CORP | 144,400 | $4.7M | 0.05% | |
| 65 | HOWLWEREWOLF THERAPEUTICS INC | 6,681,307 | $4.2M | 0.04% | |
| 66 | HNGEHINGE HEALTH INC-A | 80,113 | $3.7M | 0.04% | |
| 67 | PGNYPROGYNY INC | 96,628 | $2.5M | 0.03% | |
| 68 | QGENQIAGEN N.V. | 43,976 | $2.1M | 0.02% | |
| 69 | KIDSORTHOPEDIATRICS CORP | 109,959 | $2.0M | 0.02% | |
| 70 | HCATHEALTH CATALYST INC | 793,749 | $1.9M | 0.02% | |
| 71 | PTNPALATIN TECHNOLOGIES INC | 70,000 | $1.1M | 0.01% |