| 1 | Point72 Asset Management, L.P. | 9,439,328 | $18.0M | 0.02% | Share |
| 2 | MORGAN STANLEY | 8,897,942 | $16.0M | 0.00% | Share |
| 3 | RA CAPITAL MANAGEMENT, L.P. | 8,000,000 | $15.3M | 0.16% | Share |
| 4 | Bain Capital Life Sciences Investors, LLC | 7,171,910 | $13.7M | 1.05% | Share |
| 5 | Lynx1 Capital Management LP | 7,098,133 | $13.6M | 2.74% | Share |
| 6 | WASATCH ADVISORS LP | 4,344,918 | $8.3M | 0.05% | Share |
| 7 | VANGUARD GROUP INC | 3,861,852 | $7.4M | 0.00% | Share |
| 8 | Soleus Capital Management, L.P. | 3,803,942 | $7.3M | 0.27% | Share |
| 9 | SILVERARC CAPITAL MANAGEMENT, LLC | 1,994,224 | $3.8M | 0.53% | Share |
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,775,783 | $3.0M | 0.00% | Share |
| 11 | RENAISSANCE TECHNOLOGIES LLC | 1,602,580 | $3.0M | 0.00% | Share |
| 12 | ORBIMED ADVISORS LLC | 1,404,902 | $2.7M | 0.05% | Share |
| 13 | GOLDMAN SACHS GROUP INC | 1,075,244 | $2.0M | 0.00% | Share |
| 14 | BlackRock, Inc. | 1,094,349 | $2.0M | 0.00% | Share |
| 15 | BANK OF AMERICA CORP /DE/ | 1,108,194 | $2.0M | 0.00% | Share |
| 16 | BANK OF AMERICA CORP /DE/ | 1,279,392 | $2.0M | 0.00% | Share |
| 17 | MILLENNIUM MANAGEMENT LLC | 1,188,969 | $2.0M | 0.00% | Share |
| 18 | TWO SIGMA INVESTMENTS, LP | 1,509,603 | $2.0M | 0.00% | Share |
| 19 | TWO SIGMA ADVISERS, LP | 1,068,200 | $2.0M | 0.00% | Share |
| 20 | WELLS FARGO & COMPANY/MN | 600,000 | $1.0M | 0.00% | Share |
| 21 | BlackRock, Inc. | 734,514 | $1.0M | 0.00% | Share |
| 22 | ACADIAN ASSET MANAGEMENT LLC | 657,173 | $1.0M | 0.00% | Share |
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 803,787 | $1.0M | 0.00% | Share |
| 24 | VANGUARD GROUP INC | 484,131 | $924K | 0.00% | Share |
| 25 | 683 Capital Management, LLC | 400,000 | $764K | 0.03% | Share |
| 26 | GROUP ONE TRADING LLC | 275,000 | $525K | 0.00% | Call |
| 27 | Invesco Ltd. | 268,350 | $512K | 0.00% | Share |
| 28 | Hennion & Walsh Asset Management, Inc. | 237,137 | $452K | 0.02% | Share |
| 29 | ArrowMark Colorado Holdings LLC | 204,505 | $390K | 0.01% | Share |
| 30 | Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | $162K | 0.08% | Share |
| 31 | Crestwood Advisors Group, LLC | 64,664 | $123K | 0.00% | Share |
| 32 | INTREPID FAMILY OFFICE LLC | 55,000 | $105K | 0.09% | Share |
| 33 | Catalyst Funds Management Pty Ltd | 42,500 | $81K | 0.02% | Share |
| 34 | GROUP ONE TRADING LLC | 38,994 | $74K | 0.00% | Share |
| 35 | VANGUARD GROUP INC | 33,832 | $64K | 0.00% | Share |
| 36 | UBS Group AG | 29,321 | $56K | 0.00% | Share |
| 37 | FARALLON CAPITAL MANAGEMENT LLC | 28,000 | $53K | 0.00% | Share |
| 38 | UBS Group AG | 22,635 | $43K | 0.00% | Share |
| 39 | Corient Private Wealth LLC | 21,387 | $40K | 0.00% | Share |
| 40 | Virtu Financial LLC | 20,655 | $39K | 0.00% | Share |
| 41 | Delta Investment Management, LLC | 20,000 | $38K | 0.01% | Share |
| 42 | EWA, LLC | 16,889 | $32K | 0.01% | Share |
| 43 | China Universal Asset Management Co., Ltd. | 15,792 | $30K | 0.00% | Share |
| 44 | R Squared Ltd | 13,674 | $26K | 0.01% | Share |
| 45 | HSBC HOLDINGS PLC | 13,629 | $26K | 0.00% | Share |
| 46 | NINE MASTS CAPITAL Ltd | 11,472 | $21K | 0.00% | Share |
| 47 | Ethic Inc. | 10,278 | $19K | 0.00% | Share |
| 48 | Bronte Capital Management Pty Ltd. | 10,033 | $19K | 0.00% | Share |
| 49 | Simplicity Wealth,LLC | 10,202 | $19K | 0.00% | Share |
| 50 | Blackston Financial Advisory Group, LLC | 10,000 | $19K | 0.01% | Share |