| 1 | RA CAPITAL MANAGEMENT, L.P. | 5,404,998 | $70.7M | 0.72% | Share |
| 2 | FCPM III SERVICES B.V. | 3,617,354 | $47.3M | 6.20% | Share |
| 3 | Frazier Life Sciences Management, L.P. | 2,543,939 | $33.3M | 0.89% | Share |
| 4 | FMR LLC | 2,522,625 | $32.0M | 0.00% | Share |
| 5 | VR Adviser, LLC | 1,943,766 | $25.4M | 1.26% | Share |
| 6 | Paradigm Biocapital Advisors LP | 1,750,000 | $22.9M | 0.58% | Share |
| 7 | GREAT POINT PARTNERS LLC | 1,370,107 | $17.9M | 5.81% | Share |
| 8 | NEXTBio Capital Management LP | 999,967 | $13.1M | 7.67% | Share |
| 9 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 999,300 | $13.0M | 0.00% | Call |
| 10 | Caligan Partners LP | 925,067 | $10.0M | 0.82% | Share |
| 11 | VANGUARD GROUP INC | 669,843 | $8.8M | 0.00% | Share |
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 410,417 | $5.4M | 1.04% | Share |
| 13 | CITADEL ADVISORS LLC | 433,894 | $5.0M | 0.00% | Share |
| 14 | Laurion Capital Management LP | 317,243 | $4.1M | 0.13% | Share |
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 355,900 | $4.0M | 0.00% | Put |
| 16 | UBS Group AG | 245,223 | $3.2M | 0.00% | Share |
| 17 | FINDELL CAPITAL MANAGEMENT LLC | 231,000 | $3.0M | 0.87% | Share |
| 18 | BlackRock, Inc. | 248,208 | $3.0M | 0.00% | Share |
| 19 | GROUP ONE TRADING LLC | 185,000 | $2.4M | 0.00% | Call |
| 20 | TUDOR INVESTMENT CORP ET AL | 167,673 | $2.0M | 0.00% | Share |
| 21 | MILLENNIUM MANAGEMENT LLC | 224,534 | $2.0M | 0.00% | Share |
| 22 | BlackRock, Inc. | 169,670 | $2.0M | 0.00% | Share |
| 23 | AMERIPRISE FINANCIAL INC | 163,061 | $2.0M | 0.00% | Share |
| 24 | Logos Global Management LP | 100,000 | $1.3M | 0.08% | Share |
| 25 | VANGUARD GROUP INC | 93,838 | $1.2M | 0.00% | Share |
| 26 | GROUP ONE TRADING LLC | 85,000 | $1.1M | 0.00% | Put |
| 27 | JANE STREET GROUP, LLC | 91,810 | $1.0M | 0.00% | Share |
| 28 | STATE STREET CORP | 91,053 | $1.0M | 0.00% | Share |
| 29 | GOLDMAN SACHS GROUP INC | 145,640 | $1.0M | 0.00% | Share |
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 150,219 | $1.0M | 0.00% | Share |
| 31 | JOHNSON & JOHNSON | 53,732 | $702K | 0.13% | Share |
| 32 | UBS Group AG | 46,895 | $613K | 0.00% | Share |
| 33 | Sarissa Capital Management LP | 25,399 | $332K | 0.15% | Share |
| 34 | Bollard Group LLC | 23,987 | $314K | 0.01% | Share |
| 35 | Persistent Asset Partners Ltd | 10,798 | $141K | 0.06% | Share |
| 36 | Shay Capital LLC | 10,745 | $140K | 0.01% | Share |
| 37 | Chung Wu Investment Group, LLC | 8,300 | $108K | 0.09% | Share |
| 38 | VANGUARD GROUP INC | 6,569 | $85K | 0.00% | Share |
| 39 | China Universal Asset Management Co., Ltd. | 2,746 | $35K | 0.00% | Share |
| 40 | Mirae Asset Global Investments Co., Ltd. | 819 | $10K | 0.00% | Share |
| 41 | GF FUND MANAGEMENT CO. LTD. | 330 | $4K | 0.00% | Share |
| 42 | BNP PARIBAS FINANCIAL MARKETS | 291 | $0 | 0.00% | Share |
| 43 | Belvedere Trading LLC | 57,400 | $0 | 0.00% | Call |
| 44 | Belvedere Trading LLC | 200 | $0 | 0.00% | Put |
| 45 | MORGAN STANLEY | 12,069 | $0 | 0.00% | Share |
| 46 | MORGAN STANLEY | 25 | $0 | 0.00% | Share |
| 47 | JPMORGAN CHASE & CO | 1,000 | $0 | 0.00% | Share |
| 48 | JPMORGAN CHASE & CO | 1,312 | $0 | 0.00% | Share |
| 49 | Susquehanna Portfolio Strategies, LLC | 10,207 | $0 | 0.00% | Share |
| 50 | Hudson Bay Capital Management LP | 5,110 | $0 | 0.00% | Share |