| 1 | RA CAPITAL MANAGEMENT, L.P. | 8,340,508 | $16.9T | 100.00% | — |
| 2 | PERCEPTIVE ADVISORS LLC | 5,360,858 | $10.9T | 0.38% | — |
| 3 | Sands Capital Alternatives, LLC | 2,122,605 | $4.3T | 1.05% | — |
| 4 | CITADEL ADVISORS LLC | 1,895,519 | $3.8T | 0.73% | — |
| 5 | BlackRock, Inc. | 938,707 | $1.9T | 0.04% | — |
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 888,130 | $1.8T | 0.35% | — |
| 7 | MARSHALL WACE, LLP | 450,391 | $914.3B | 1.16% | — |
| 8 | ACORN CAPITAL ADVISORS, LLC | 405,237 | $822.6B | 0.57% | — |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | 306,111 | $620.0B | 0.05% | — |
| 10 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,320 | $226.0B | 0.04% | — |
| 11 | NORTHERN TRUST CORP | 109,025 | $221.3B | 0.03% | — |
| 12 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,900 | $158.1B | 0.00% | — |
| 13 | GOLDMAN SACHS GROUP INC | 57,519 | $116.8B | 0.02% | — |
| 14 | WEALTHEDGE INVESTMENT ADVISORS, LLC | 56,467 | $114.6B | 0.05% | — |
| 15 | RENAISSANCE TECHNOLOGIES LLC | 52,100 | $105.8B | 0.16% | — |
| 16 | DIMENSIONAL FUND ADVISORS LP | 44,154 | $90.0B | 0.02% | — |
| 17 | Invesco Ltd. | 35,315 | $71.7B | 0.01% | — |
| 18 | MORGAN STANLEY | 35,221 | $69.0B | 0.00% | — |
| 19 | BARCLAYS PLC | 32,698 | $66.0B | 0.02% | — |
| 20 | BANK OF AMERICA CORP /DE/ | 27,699 | $55.0B | 0.00% | — |
| 21 | EXCHANGE TRADED CONCEPTS, LLC | 23,161 | $47.0B | 0.81% | — |
| 22 | BAKER BROS. ADVISORS LP | 22,809 | $46.3B | 0.51% | — |
| 23 | AMERICAN CENTURY COMPANIES INC | 17,381 | $35.3B | 0.02% | — |
| 24 | RHUMBLINE ADVISERS | 16,600 | $33.7B | 0.03% | — |
| 25 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 15,576 | $31.6B | 0.00% | — |
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,580 | $29.6B | 0.01% | — |
| 27 | Nuveen, LLC | 13,402 | $27.2B | 0.01% | — |
| 28 | PRELUDE CAPITAL MANAGEMENT, LLC | 13,067 | $26.5B | 0.00% | — |
| 29 | UBS Group AG | 12,888 | $26.2B | 0.00% | — |
| 30 | CITIGROUP INC | 11,159 | $22.7B | 0.01% | — |
| 31 | AAF Wealth Management, LLC | 10,678 | $21.7B | 0.01% | — |
| 32 | WELLS FARGO & COMPANY/MN | 7,090 | $14.4B | 0.00% | — |
| 33 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,087 | $14.4B | 0.03% | — |
| 34 | Corebridge Financial, Inc. | 5,787 | $11.7B | 0.07% | — |
| 35 | Tower Research Capital LLC (TRC) | 3,090 | $6.3B | 0.00% | — |
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 2,314 | $5.0B | 0.01% | — |
| 37 | STRS OHIO | 800 | $4.8B | 0.02% | — |
| 38 | Mirae Asset Global Investments Co., Ltd. | 1,042 | $2.3B | 0.01% | — |
| 39 | ROYAL BANK OF CANADA | 849 | $2.0B | 0.00% | — |
| 40 | NISA INVESTMENT ADVISORS, LLC | 959 | $1.9B | 0.01% | — |
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 856 | $1.7B | 0.00% | — |
| 42 | Legal & General Group Plc | 839 | $1.7B | 0.00% | — |
| 43 | GF FUND MANAGEMENT CO. LTD. | 772 | $1.6B | 0.00% | — |
| 44 | Ameritas Investment Partners, Inc. | 695 | $1.4B | 0.00% | — |
| 45 | VANGUARD GROUP INC | 674,790 | $1.4B | 0.02% | — |
| 46 | DEUTSCHE BANK AG\ | 541 | $1.1B | 0.00% | — |
| 47 | Redwood Park Advisors LLC | 500 | $1.0B | 0.00% | — |
| 48 | STATE STREET CORP | 232,551 | $472.0M | 0.00% | — |
| 49 | Sterling Capital Management LLC | 198 | $402.0M | 0.01% | — |
| 50 | GAMMA Investing LLC | 583 | $287.0M | 0.00% | — |