| 1 | RA CAPITAL MANAGEMENT, L.P. | 9,853,302 | $42.3M | 0.43% | Share |
| 2 | 5AM Venture Management, LLC | 2,353,304 | $10.1M | 3.17% | Share |
| 3 | VR Adviser, LLC | 1,609,569 | $6.9M | 0.34% | Share |
| 4 | venBio Partners LLC | 648,507 | $2.8M | 1.29% | Share |
| 5 | FRANKLIN RESOURCES INC | 520,327 | $2.0M | 0.00% | Share |
| 6 | Revelation Capital Management, LLC | 299,311 | $1.3M | 1.54% | Share |
| 7 | VANGUARD GROUP INC | 207,686 | $890K | 0.00% | Share |
| 8 | VANGUARD GROUP INC | 32,810 | $140K | 0.00% | Share |
| 9 | UBS Group AG | 31,277 | $134K | 0.00% | Share |
| 10 | Scientech Research LLC | 27,757 | $119K | 0.07% | Share |
| 11 | UBS Group AG | 5,596 | $24K | 0.00% | Share |
| 12 | VANGUARD GROUP INC | 5,510 | $23K | 0.00% | Share |
| 13 | MARK SHEPTOFF FINANCIAL PLANNING, LLC | 400 | $1K | 0.00% | Share |
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 194,108 | $0 | 0.00% | Share |
| 15 | Russell Investments Group, Ltd. | 5,491 | $0 | 0.00% | Share |
| 16 | BlackRock, Inc. | 915 | $0 | 0.00% | Share |
| 17 | BlackRock, Inc. | 7,937 | $0 | 0.00% | Share |
| 18 | BlackRock, Inc. | 203,686 | $0 | 0.00% | Share |
| 19 | FMR LLC | 3,558 | $0 | 0.00% | Share |
| 20 | Tower Research Capital LLC (TRC) | 1,103 | $0 | 0.00% | Share |
| 21 | STATE STREET CORP | 35,824 | $0 | 0.00% | Share |
| 22 | GOLDMAN SACHS GROUP INC | 12,060 | $0 | 0.00% | Share |
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 90,940 | $0 | 0.00% | Share |
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 10,177 | $0 | 0.00% | Share |
| 25 | MARSHALL WACE, LLP | 431 | $0 | 0.00% | Share |
| 26 | MARSHALL WACE, LLP | 67,858 | $0 | 0.00% | Share |
| 27 | MARSHALL WACE, LLP | 11,270 | $0 | 0.00% | Share |
| 28 | ROYAL BANK OF CANADA | 6 | $0 | 0.00% | Share |
| 29 | ROYAL BANK OF CANADA | 333 | $0 | 0.00% | Share |
| 30 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 35,000 | $0 | 0.00% | Share |
| 31 | TWO SIGMA INVESTMENTS, LP | 144,864 | $0 | 0.00% | Share |
| 32 | MILLENNIUM MANAGEMENT LLC | 217,097 | $0 | 0.00% | Share |
| 33 | RENAISSANCE TECHNOLOGIES LLC | 116,200 | $0 | 0.00% | Share |
| 34 | BANK OF AMERICA CORP /DE/ | 105 | $0 | 0.00% | Share |
| 35 | BANK OF AMERICA CORP /DE/ | 8 | $0 | 0.00% | Share |
| 36 | OMERS ADMINISTRATION Corp | 21,100 | $0 | 0.00% | Share |
| 37 | BNP PARIBAS FINANCIAL MARKETS | 542 | $0 | 0.00% | Share |
| 38 | MORGAN STANLEY | 26,846 | $0 | 0.00% | Share |
| 39 | MORGAN STANLEY | 226 | $0 | 0.00% | Share |
| 40 | JPMORGAN CHASE & CO | 82 | $0 | 0.00% | Share |
| 41 | JPMORGAN CHASE & CO | 105 | $0 | 0.00% | Share |
| 42 | Alyeska Investment Group, L.P. | 100,000 | $0 | 0.00% | Share |
| 43 | OSAIC HOLDINGS, INC. | 32 | $0 | 0.00% | Share |
| 44 | WELLS FARGO & COMPANY/MN | 1,500 | $0 | 0.00% | Share |
| 45 | PRELUDE CAPITAL MANAGEMENT, LLC | 10,691 | $0 | 0.00% | Share |
| 46 | JANE STREET GROUP, LLC | 40,671 | $0 | 0.00% | Share |