Who Owns Tyra Biosciences, Inc. (TYRA)?Hedge Fund & Institutional Holders

$35.87-0.13 (-0.36%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

1.1025956978268063e+278%

QoQ Change in Holders

+4 / -8

Price History

$7.06$14.43$21.80$29.17$36.54Sep 24Jun 25Mar 26

TYRA — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
FARALLON CAPITAL MANAGEMENT LLCIncreased+923K+$38.3B
JANUS HENDERSON GROUP PLCIncreased+61K+$36.8B
Point72 Asset Management, L.P.Increased+592K+$18.1B
Caligan Partners LPIncreased+247K+$15.1B
5AM Venture Management, LLCIncreased+90K+$13.9B
BOONE CAPITAL MANAGEMENT LLCNew Position+398K+$10.5B
Sio Capital Management, LLCIncreased+11K+$6.6B
Logos Global Management LPNew Position+210K+$5.5B
Eversept Partners, LPIncreased+6K+$3.5B
Soleus Capital Management, L.P.New Position+125K+$3.3B
Invesco Ltd.Increased+114K+$3.2B
GOLDMAN SACHS GROUP INCIncreased+82K+$2.6B
OPPENHEIMER & CO INCNew Position+85K+$2.2B
DIMENSIONAL FUND ADVISORS LPIncreased+56K+$1.4B
RAYMOND JAMES FINANCIAL INCIncreased+44K+$1.2B

TYRA — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Alta Partners Management Company, L.P.Decreased-257K-$57.0B
Walleye Capital LLCClosed Position-298K-$4.2B
RENAISSANCE TECHNOLOGIES LLCClosed Position-170K-$2.4B
AXA Investment Managers S.A.Closed Position-129K-$1.8B
CITADEL ADVISORS LLCClosed Position-111K-$1.6B
HighVista Strategies LLCDecreased-31K-$920.7M
Jump Financial, LLCClosed Position-62K-$867.4M
TWO SIGMA INVESTMENTS, LPDecreased-92K-$790.1M
JANE STREET GROUP, LLCClosed Position-45K-$625.1M
TWO SIGMA ADVISERS, LPDecreased-54K-$583.7M
Cubist Systematic Strategies, LLCClosed Position-39K-$549.9M
JACOBS LEVY EQUITY MANAGEMENT, INCDecreased-122K-$519.4M
XTX Topco LtdDecreased-3K-$471.5M
ALLIANCEBERNSTEIN L.P.Decreased-1K-$465.3M
Brevan Howard Capital Management LPClosed Position-31K-$435.1M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1Nextech Invest, Ltd.4,055,861$106.6B10.31%Share
2Commodore Capital LP3,375,000$88.7B5.91%Share
3JANUS HENDERSON GROUP PLC2,935,442$77.0B0.03%Share
4TCG Crossover Management, LLC2,898,103$76.2B2.52%Share
5Vestal Point Capital, LP2,425,000$63.8B2.17%Share
6BVF INC/IL2,127,665$55.9B1.88%Share
7FARALLON CAPITAL MANAGEMENT LLC2,066,818$54.3B0.26%Share
8Kynam Capital Management, LP1,564,492$41.1B2.63%Share
95AM Venture Management, LLC1,029,298$27.1B8.51%Share
10Caligan Partners LP944,257$24.8B2.04%Share
11Point72 Asset Management, L.P.874,192$22.0B0.02%Share
12BALYASNY ASSET MANAGEMENT L.P.818,326$21.0B0.03%Share
13Sio Capital Management, LLC526,002$13.8B2.18%Share
14BOONE CAPITAL MANAGEMENT LLC398,482$10.5B3.29%Share
15Eversept Partners, LP278,564$7.3B0.37%Share
16Logos Global Management LP210,000$5.5B0.33%Share
17CHARLES SCHWAB INVESTMENT MANAGEMENT INC199,426$5.0B0.00%Share
18NORTHERN TRUST CORP188,835$4.0B0.00%Share
19GOLDMAN SACHS GROUP INC182,387$4.0B0.00%Share
20Soleus Capital Management, L.P.125,000$3.3B0.12%Share
21Invesco Ltd.115,906$3.0B0.00%Share
22JACOBS LEVY EQUITY MANAGEMENT, INC129,753$3.0B0.01%Share
23MILLENNIUM MANAGEMENT LLC114,388$3.0B0.00%Share
24RAYMOND JAMES FINANCIAL INC123,016$3.0B0.00%Share
25OPPENHEIMER & CO INC84,726$2.2B0.03%Share
26DIMENSIONAL FUND ADVISORS LP86,941$2.0B0.00%Share
27TWO SIGMA INVESTMENTS, LP107,023$2.0B0.00%Share
28BARCLAYS PLC76,299$2.0B0.00%Share
29UBS Group AG49,347$1.3B0.00%Share
30PDT Partners, LLC42,284$1.1B0.07%Share
31AMERICAN CENTURY COMPANIES INC46,227$1.0B0.00%Share
32AMERIPRISE FINANCIAL INC54,625$1.0B0.00%Share
33ALPS ADVISORS INC43,827$1.0B0.01%Share
34ExodusPoint Capital Management, LP42,791$1.0B0.01%Share
35RHUMBLINE ADVISERS38,790$1.0B0.00%Share
36STATE OF WISCONSIN INVESTMENT BOARD39,023$1.0B0.00%Share
37TWO SIGMA ADVISERS, LP58,900$1.0B0.00%Share
38WELLINGTON MANAGEMENT GROUP LLP50,642$1.0B0.00%Share
39SUSQUEHANNA INTERNATIONAL GROUP, LLP55,135$1.0B0.00%Share
40Y-Intercept (Hong Kong) Ltd45,942$1.0B0.02%Share
41WELLINGTON MANAGEMENT GROUP LLP50,285$1.0B0.00%Share
42JPMORGAN CHASE & CO52,265$1.0B0.00%Share
43Nuveen, LLC47,349$1.0B0.00%Share
44Auour Investments LLC21,020$552.0M0.18%Share
45RA CAPITAL MANAGEMENT, L.P.12,198,625$320.7M3.29%Share
46Virtus Investment Advisers, LLC11,756$309.0M0.08%Share
47BAKER BROS. ADVISORS LP10,607$278.0M0.00%Share
48Invesco Ltd.9,536$250.0M0.00%Share
49UBS Group AG9,322$245.0M0.00%Share
50Invesco Ltd.3,993$104.0M0.00%Share

TYRA Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025132$750.3B+35
Q3 202597$653.3B+0
Q2 202597$453.7B-21
Q1 2025118$461.7B+8
Q4 2024110$511.1B+31
Q3 202479$3.1T+12
Q2 202467$1.9T+0
Q1 202467$901.0B—

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As of Q4 2025, 50 institutional investors hold TYRA (Tyra Biosciences, Inc.). The largest holder is Nextech Invest, Ltd. with $106.6B in shares. This quarter, 4 institutions opened new positions and 8 closed their positions.

Frequently Asked Questions

How many hedge funds own TYRA?

As of Q4 2025, 50 institutional investors report holding TYRA (Tyra Biosciences, Inc.) in their 13F filings.

Who is the largest institutional holder of TYRA?

The largest institutional holder of TYRA is Nextech Invest, Ltd. with $106.6B in shares.

Is institutional ownership of TYRA increasing or decreasing?

This quarter, 4 institutions opened new positions in TYRA and 8 closed their positions.