Siren, L.L.C. Q3 2025 Filing
Filed November 13, 2025
Portfolio Value
$2.6B
Holdings
115
Report Date
Q3 2025
Filing Type
13F-HR
All Holdings (115 positions)
| Stock | Value |
|---|---|
SRRKScholar Rock Holding Corp | $344.5M |
KYMRKymera Therapeutics Inc | $194.0M |
ONCBeOne Medicines AG | $168.0M |
ARWRArrowhead Pharmaceuticals Inc | $92.1M |
BCAXBicara Therapeutics Inc | $82.4M |
CNTACentessa Pharmaceuticals PLC | $78.3M |
CRNXCrinetics Pharmaceuticals Inc | $70.3M |
EWTXEdgewise Therapeutics Inc | $63.2M |
IRONDisc Medicine Inc | $60.4M |
DYNDyne Therapeutics Inc | $59.8M |
APLSApellis Pharmaceuticals Inc | $58.3M |
RNAAvidity Biosciences Inc | $56.0M |
STOKStoke Therapeutics Inc | $52.8M |
LXRXLexicon Pharmaceuticals Inc | $52.5M |
RYTMRhythm Pharmaceuticals Inc | $50.5M |
TNGXTango Therapeutics Inc | $49.4M |
RVMDRevolution Medicines Inc | $48.7M |
ASNDAscendis Pharma A/S | $46.9M |
RZLTRezolute Inc | $45.8M |
SLDBSolid Biosciences Inc | $45.8M |
SEPNSepterna Inc | $41.4M |
RCUSArcus Biosciences Inc | $39.6M |
TSHATaysha Gene Therapies Inc | $36.0M |
TBLATaboola.com Ltd | $34.0M |
XENEXenon Pharmaceuticals Inc | $32.6M |
SLNOSoleno Therapeutics Inc | $31.6M |
RAPPRapport Therapeutics Inc | $31.3M |
GPCRStructure Therapeutics Inc | $28.8M |
WVEWAVE Life Sciences Ltd | $27.1M |
RELYRemitly Global Inc | $26.4M |
COGTCogent Biosciences Inc | $24.8M |
TRVITrevi Therapeutics Inc | $23.2M |
NAMSNewAmsterdam Pharma Company NV | $21.8M |
KRROKorro Bio Inc | $20.1M |
ERASErasca Inc | $19.1M |
IHSIHS Holding Limited | $16.1M |
QUREUniqure NV | $16.1M |
BCYCBicycle Therapeutics PLC | $15.6M |
SLNSilence Therapeutics PLC | $15.1M |
RAPTRAPT Therapeutics Inc | $15.0M |
UPBUpstream Bio Inc | $14.8M |
GOSSGossamer Bio Inc | $13.7M |
AVBPArrivent Biopharma Inc | $12.9M |
AMZNAmazon.com Inc | $12.8M |
ORICOric Pharmaceuticals Inc | $12.1M |
DNLIDenali Therapeutics Inc | $11.9M |
IONQIONQ Inc | $10.5M |
SIONSionna Therapeutics Inc | $9.6M |
CRWDCrowdStrike Holdings Inc | $9.1M |
MSFTMicrosoft Corp | $8.9M |
SEERSeer Inc | $8.7M |
NBISNebius Group NV | $8.2M |
NMRANeumora Therapeutics Inc | $7.9M |
TSMTaiwan Semiconductor Manufacturing Co Ltd | $7.9M |
CRMSalesforce Inc | $7.1M |
CGEMCullinan Therapeutics Inc | $7.1M |
NVDANVIDIA Corp | $7.0M |
NOWServiceNow Inc | $6.6M |
SYRESpyre Therapeutics Inc | $6.2M |
RNACCartesian Therapeutics Inc | $5.8M |
PDDPDD Holdings Inc | $5.7M |
ELDNEledon Pharmaceuticals Inc | $5.4M |
ADBEAdobe Inc | $5.3M |
GOOGLAlphabet Inc | $5.2M |
FROGJfrog Ltd | $5.1M |
SGMTSagimet Biosciences Inc | $5.0M |
DTDynatrace Inc | $4.9M |
DDOGDatadog Inc | $4.7M |
NBPI-Mab | $4.4M |
AGENAgenus Inc | $4.1M |
LXEOLexeo Therapeutics Inc | $4.0M |
BDTXBlack Diamond Therapeutics Inc | $4.0M |
WHWKWhitehawk Therapeutics Inc | $4.0M |
VTVTvTv Therapeutics Inc | $3.8M |
TILInstil Bio Inc | $3.6M |
FHTXFoghorn Therapeutics Inc | $3.5M |
PRQRProQR Therapeutics NV | $3.3M |
N1UANew Oriental Education & Technology Group Inc | $3.3M |
CRWVCoreWeave Inc | $3.3M |
PEPGPepGen Inc | $3.2M |
GTLBGitLab Inc | $2.9M |
BEKEKe Holdings Inc | $2.8M |
PANWPalo Alto Networks Inc | $2.7M |
TENXTenax Therapeutics Inc | $2.7M |
WKWorkiva Inc | $2.6M |
QCOMQualcomm Inc | $2.3M |
BIOABIOAGE Labs Inc | $2.2M |
KDPKeurig Dr Pepper Inc | $2.0M |
HUBSHubSpot Inc | $1.9M |
CMGChipotle Mexican Grill Inc | $1.9M |
KLRSKalaris Therapeutics Inc | $1.8M |
GBIOGeneration Bio Co | $1.8M |
CLBTCellebrite DI Ltd | $1.7M |
PRMBPrimo Brands Corp | $1.7M |
SPOTSpotify Technology SA | $1.5M |
NIQNIQ Global Intelligence PLC | $1.5M |
MNDYmonday.com Ltd | $1.4M |
SAILSailPoint Inc | $1.1M |
ESTCElastic NV | $1.1M |
IRENIREN Ltd | $938K |
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