ORBIMED ADVISORS LLC Q3 2025 Filing
Filed November 14, 2025
Portfolio Value
$4.3T
Holdings
104
Report Date
Q3 2025
Filing Type
13F-HR
All Holdings (104 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | BSXBOSTON SCIENTIFIC CORP | 2,629,300 | $256.7B | 6.03% | Call |
| 2 | EWTXEDGEWISE THERAPEUTICS INC | 15,518,492 | $251.7B | 5.92% | |
| 3 | LLYELI LILLY & CO | 301,200 | $229.8B | 5.40% | |
| 4 | SVASINOVAC BIOTECH LTD | 2,718,735 | $184.5B | 4.33% | |
| 5 | ELVNENLIVEN THERAPEUTICS INC | 7,959,538 | $162.9B | 3.83% | |
| 6 | ALNYALNYLAM PHARMACEUTICALS INC | 301,600 | $137.5B | 3.23% | |
| 7 | SYKSTRYKER CORPORATION | 359,200 | $132.8B | 3.12% | |
| 8 | EWEDWARDS LIFESCIENCES CORP | 1,684,000 | $131.0B | 3.08% | |
| 9 | ISRGINTUITIVE SURGICAL INC | 287,200 | $128.4B | 3.02% | |
| 10 | ARGXARGENX SE | 172,300 | $127.1B | 2.99% | |
| 11 | SIONSIONNA THERAPEUTICS INC | 3,704,959 | $109.0B | 2.56% | |
| 12 | UPBUPSTREAM BIO INC | 5,693,589 | $107.1B | 2.52% | |
| 13 | IRONDISC MEDICINE INC | 1,415,020 | $93.5B | 2.20% | |
| 14 | CAICARIS LIFE SCIENCES INC | 3,034,858 | $91.8B | 2.16% | |
| 15 | SPRYARS PHARMACEUTICALS INC | 8,288,510 | $83.3B | 1.96% | |
| 16 | RNAAVIDITY BIOSCIENCES INC | 1,638,886 | $71.4B | 1.68% | |
| 17 | MBXMBX BIOSCIENCES INC | 4,002,887 | $70.1B | 1.65% | |
| 18 | CGONCG ONCOLOGY INC | 1,726,850 | $69.6B | 1.63% | |
| 19 | NTRANATERA INC | 429,300 | $69.1B | 1.62% | |
| 20 | AXSMAXSOME THERAPEUTICS INC | 531,800 | $64.6B | 1.52% | |
| 21 | APLSAPELLIS PHARMACEUTICALS INC | 2,573,368 | $58.2B | 1.37% | Call |
| 22 | TERNTERNS PHARMACEUTICALS INC | 7,562,971 | $56.8B | 1.33% | |
| 23 | AVBPARRIVENT BIOPHARMA INC | 3,027,328 | $55.9B | 1.31% | |
| 24 | MLYSMINERALYS THERAPEUTICS INC | 1,469,494 | $55.7B | 1.31% | |
| 25 | EXASEXACT SCIENCES CORP | 994,616 | $54.4B | 1.28% | |
| 26 | CMPXCOMPASS THERAPEUTICS INC | 15,219,994 | $53.3B | 1.25% | |
| 27 | CRVSCORVUS PHARMACEUTICALS INC | 7,165,006 | $52.8B | 1.24% | |
| 28 | DHRDANAHER CORPORATION | 263,100 | $52.2B | 1.23% | |
| 29 | CRNXCRINETICS PHARMACEUTICALS IN | 1,199,000 | $49.9B | 1.17% | Put |
| 30 | NBIXNEUROCRINE BIOSCIENCES INC | 353,640 | $49.6B | 1.17% | |
| 31 | UTHUNITED THERAPEUTICS CORP DEL | 114,900 | $48.2B | 1.13% | |
| 32 | CITHE CIGNA GROUP | 162,800 | $46.9B | 1.10% | |
| 33 | ORICORIC PHARMACEUTICALS INC | 3,641,756 | $43.7B | 1.03% | |
| 34 | JANXJANUX THERAPEUTICS INC | 1,766,100 | $43.2B | 1.01% | |
| 35 | ROIVROIVANT SCIENCES LTD | 2,714,798 | $41.1B | 0.97% | |
| 36 | ASNDASCENDIS PHARMA A/S | 191,905 | $38.2B | 0.90% | |
| 37 | SIBNSI-BONE INC | 2,578,979 | $38.0B | 0.89% | |
| 38 | SCPHSCPHARMACEUTICALS INC | 6,059,528 | $34.4B | 0.81% | |
| 39 | ABVXABIVAX SA | 380,000 | $32.3B | 0.76% | |
| 40 | GPCRSTRUCTURE THERAPEUTICS INC | 1,139,300 | $31.9B | 0.75% | |
| 41 | TRVITREVI THERAPEUTICS INC | 3,308,400 | $30.3B | 0.71% | |
| 42 | ITGRINTEGER HLDGS CORP | 290,000 | $30.0B | 0.70% | |
| 43 | DYNDYNE THERAPEUTICS INC | 2,314,184 | $29.3B | 0.69% | |
| 44 | RAPTRAPT THERAPEUTICS INC | 1,086,618 | $28.0B | 0.66% | |
| 45 | CTMXCYTOMX THERAPEUTICS INC | 8,461,500 | $27.0B | 0.63% | |
| 46 | NPCENEUROPACE INC | 2,614,184 | $27.0B | 0.63% | |
| 47 | QUREUNIQURE NV | 458,500 | $26.8B | 0.63% | |
| 48 | EYPTEYEPOINT PHARMACEUTICALS INC | 1,796,000 | $25.6B | 0.60% | |
| 49 | AKROAKERO THERAPEUTICS INC | 526,200 | $25.0B | 0.59% | |
| 50 | ADCTADC THERAPEUTICS SA | 5,907,351 | $23.6B | 0.56% | |
| 51 | TMOTHERMO FISHER SCIENTIFIC INC | 46,500 | $22.6B | 0.53% | |
| 52 | RYTMRHYTHM PHARMACEUTICALS INC | 215,152 | $21.7B | 0.51% | |
| 53 | ABTABBOTT LABS | 150,000 | $20.1B | 0.47% | Call |
| 54 | KRYSKRYSTAL BIOTECH INC | 102,745 | $18.1B | 0.43% | |
| 55 | FBRXFORTE BIOSCIENCES INC | 1,196,955 | $18.0B | 0.42% | |
| 56 | AVTXAVALO THERAPEUTICS INC | 1,349,300 | $17.1B | 0.40% | |
| 57 | XENEXENON PHARMACEUTICALS INC | 419,600 | $16.8B | 0.40% | |
| 58 | CARLCARLSMED INC | 1,252,600 | $16.8B | 0.39% | |
| 59 | KROSKEROS THERAPEUTICS INC | 1,018,734 | $16.1B | 0.38% | |
| 60 | PRLDPRELUDE THERAPEUTICS INC | 10,909,256 | $15.7B | 0.37% | |
| 61 | STTKSHATTUCK LABS INC | 6,306,127 | $15.1B | 0.35% | |
| 62 | CRBPCORBUS PHARMACEUTICALS HLDGS | 1,172,287 | $14.8B | 0.35% | |
| 63 | URGNUROGEN PHARMA LTD | 689,000 | $13.7B | 0.32% | |
| 64 | VIRVIR BIOTECHNOLOGY INC | 2,380,715 | $13.6B | 0.32% | |
| 65 | AM6AMICUS THERAPEUTICS INC | 1,645,400 | $13.0B | 0.30% | |
| 66 | PFEPFIZER INC | 500,000 | $12.7B | 0.30% | Call |
| 67 | BTSGBRIGHTSPRING HEALTH SVCS INC | 413,800 | $12.2B | 0.29% | Call |
| 68 | TARSTARSUS PHARMACEUTICALS INC | 197,900 | $11.8B | 0.28% | |
| 69 | CCCCC4 THERAPEUTICS INC | 5,235,146 | $11.6B | 0.27% | |
| 70 | AZNASTRAZENECA PLC | 150,000 | $11.5B | 0.27% | Call |
| 71 | CGEMCULLINAN THERAPEUTICS INC | 1,923,855 | $11.4B | 0.27% | |
| 72 | VTGNVISTAGEN THERAPEUTICS INC | 3,105,200 | $11.0B | 0.26% | Call |
| 73 | AMLXAMYLYX PHARMACEUTICALS INC | 750,600 | $10.2B | 0.24% | |
| 74 | TORCEURADICET BIO INC | 11,447,140 | $9.3B | 0.22% | |
| 75 | PMVPPMV PHARMACEUTICALS INC | 5,975,291 | $8.4B | 0.20% | |
| 76 | IMAPRELUDE THERAPEUTICS INC | 5,680,186 | $8.2B | 0.19% | |
| 77 | WHWKWHITEHAWK THERAPEUTICS INC | 4,166,000 | $7.9B | 0.19% | |
| 78 | VSTMVERASTEM INC | 887,561 | $7.8B | 0.18% | |
| 79 | ALMSALUMIS INC | 1,926,423 | $7.7B | 0.18% | |
| 80 | BCRXBIOCRYST PHARMACEUTICALS INC | 901,500 | $6.8B | 0.16% | |
| 81 | MISTMILESTONE PHARMACEUTICALS IN | 3,221,828 | $6.4B | 0.15% | |
| 82 | RPTXREPARE THERAPEUTICS INC | 3,322,488 | $5.8B | 0.14% | |
| 83 | NSPRINSPIREMD INC | 2,133,405 | $5.1B | 0.12% | |
| 84 | BIOABIOAGE LABS INC | 790,901 | $4.7B | 0.11% | |
| 85 | JBIOJADE BIOSCIENCES INC | 531,163 | $4.6B | 0.11% | |
| 86 | QTTBQ32 BIO INC | 2,252,987 | $4.5B | 0.10% | |
| 87 | BRD1EURMIND MEDICINE MINDMED INC | 367,824 | $4.3B | 0.10% | |
| 88 | IMAIMAGENEBIO INC | 530,713 | $4.3B | 0.10% | |
| 89 | CELCCELCUITY INC | 84,020 | $4.2B | 0.10% | |
| 90 | IMTXIMMATICS N.V | 466,601 | $4.0B | 0.09% | |
| 91 | SRRKSCHOLAR ROCK HLDG CORP | 100,000 | $3.7B | 0.09% | Call |
| 92 | TGTXTG THERAPEUTICS INC | 100,000 | $3.6B | 0.08% | Call |
| 93 | IMAIMAGENEBIO INC | 378,556 | $3.1B | 0.07% | |
| 94 | CELC 2.75 08/01/31CELCUITY INC | 2,000,000 | $2.7B | 0.06% | |
| 95 | IM8NINSMED INC | 13,459 | $1.9B | 0.05% | |
| 96 | ATAIATAI LIFE SCIENCES NV | 347,000 | $1.8B | 0.04% | |
| 97 | KRROKORRO BIO INC | 32,400 | $1.6B | 0.04% | |
| 98 | —MURAL ONCOLOGY PUB LTD CO | 588,800 | $1.2B | 0.03% | |
| 99 | TRAWTRAWS PHARMA INC | 605,531 | $1.1B | 0.03% | |
| 100 | ANROALTO NEUROSCIENCE INC | 250,000 | $1.0B | 0.02% |
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