Who Owns Krystal Biotech, Inc. (KRYS)?Hedge Fund & Institutional Holders

$248.28-3.02 (-1.20%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

1.4294259623244733e+271%

QoQ Change in Holders

+3 / -5

Price History

$123.36$165.50$207.64$249.79$291.93Sep 24Jun 25Mar 26

KRYS — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
FMR LLCIncreased+8K+$1.1T
Avoro Capital Advisors LLCIncreased+111K+$221.9B
Bellevue Group AGIncreased+409K+$100.9B
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLCIncreased+227K+$66.4B
Capital World InvestorsIncreased+260+$56.1B
JANUS HENDERSON GROUP PLCIncreased+209K+$51.2B
Redmile Group, LLCIncreased+16K+$50.3B
BANK OF AMERICA CORP /DE/Increased+53K+$45.0B
Hood River Capital Management LLCIncreased+6K+$44.1B
PRINCIPAL FINANCIAL GROUP INCNew Position+165K+$40.7B
FRANKLIN RESOURCES INCIncreased+106K+$26.5B
UBS Group AGIncreased+29K+$16.4B
ORBIMED ADVISORS LLCIncreased+17K+$11.4B
Palisades Investment Partners, LLCNew Position+43K+$10.5B
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLCNew Position+37K+$9.0B

KRYS — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
MILLENNIUM MANAGEMENT LLCDecreased-134K-$23.3B
CITADEL ADVISORS LLCDecreased-250K-$17.4B
KENNEDY CAPITAL MANAGEMENT LLCDecreased-35K-$5.8B
Verition Fund Management LLCDecreased-14K-$5.5B
Ikarian Capital, LLCDecreased-10K-$4.3B
VICTORY CAPITAL MANAGEMENT INCDecreased-28K-$3.7B
SYNOVUS FINANCIAL CORPClosed Position-21K-$3.6B
Fieldview Capital Management, LLCClosed Position-15K-$2.6B
STATE OF WISCONSIN INVESTMENT BOARDDecreased-15K-$2.2B
ACUTA CAPITAL PARTNERS, LLCClosed Position-11K-$1.9B
PERCEPTIVE ADVISORS LLCDecreased-18K-$1.9B
SCHRODER INVESTMENT MANAGEMENT GROUPClosed Position-10K-$1.8B
Connor, Clark & Lunn Investment Management Ltd.Closed Position-10K-$1.7B
BOOTHBAY FUND MANAGEMENT, LLCDecreased-5K-$1.6B
Decheng Capital LLCDecreased-15K-$1.4B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1FMR LLC3,303,458$814.0B41.50%Share
2Avoro Capital Advisors LLC2,888,888$712.2B7000.19%Share
3FMR LLC1,039,153$256.0B13.05%Share
4Soleus Capital Management, L.P.941,059$232.0B8.56%Share
5Capital World Investors809,500$199.0B27.06%Share
6Redmile Group, LLC677,705$167.1B12.30%Share
7Hood River Capital Management LLC613,302$151.2B1657.62%Share
8Frazier Life Sciences Management, L.P.488,460$120.4B3.23%Share
9DIMENSIONAL FUND ADVISORS LP467,644$115.0B24.12%Share
10Bellevue Group AG408,920$100.8B1910.48%Share
11CITADEL ADVISORS LLC386,504$95.0B14.27%Share
12WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC376,340$92.8B258.79%Share
13FIRST TRUST ADVISORS LP245,276$60.0B43.61%Share
14CHARLES SCHWAB INVESTMENT MANAGEMENT INC242,774$59.0B9.17%Share
15JANUS HENDERSON GROUP PLC209,369$51.0B22.84%Share
16NORTHERN TRUST CORP204,520$50.0B6.37%Share
17GOLDMAN SACHS GROUP INC190,288$46.0B5.67%Share
18PRINCIPAL FINANCIAL GROUP INC163,610$40.3B20.59%Share
19UBS Group AG157,640$38.9B6.30%Share
20Woodline Partners LP150,616$37.0B143.36%Share
21FRANKLIN RESOURCES INC123,602$30.0B7.36%Share
22ORBIMED ADVISORS LLC119,800$29.5B0.60%Share
23Caption Management, LLC105,300$26.0B178.02%Call
24GOLDMAN SACHS GROUP INC101,436$25.0B3.08%Share
25TimesSquare Capital Management, LLC97,400$24.0B361.71%Share
26S Squared Technology, LLC96,215$23.7B9.19%Share
27BANK OF AMERICA CORP /DE/91,361$22.0B1.60%Share
28PUBLIC SECTOR PENSION INVESTMENT BOARD89,362$22.0B73.87%Share
29SEGALL BRYANT & HAMILL, LLC83,246$20.5B277.78%Share
30Nuveen, LLC85,125$20.0B5.24%Share
31RAYMOND JAMES FINANCIAL INC71,707$17.0B5.29%Share
32RHUMBLINE ADVISERS66,436$16.0B12.94%Share
33VOYA INVESTMENT MANAGEMENT LLC66,896$16.0B15.77%Share
34JPMORGAN CHASE & CO64,513$15.0B0.94%Share
35BARCLAYS PLC60,046$14.0B3.36%Share
36Nuveen, LLC53,211$13.0B3.40%Share
37TD ASSET MANAGEMENT INC54,142$13.0B10.46%Share
38JPMORGAN CHASE & CO55,658$13.0B0.82%Share
39AMERIPRISE FINANCIAL INC51,058$12.0B2.71%Share
40Nuveen, LLC50,758$12.0B3.14%Share
41BANK OF AMERICA CORP /DE/48,986$12.0B0.87%Share
42Skandinaviska Enskilda Banken AB (publ)46,732$11.0B44.12%Share
43SUSQUEHANNA INTERNATIONAL GROUP, LLP45,200$11.0B1.27%Call
44Palisades Investment Partners, LLC42,765$10.5B3.98%Share
45Swiss National Bank42,900$10.0B5.95%Share
46MANUFACTURERS LIFE INSURANCE COMPANY, THE40,629$10.0B8.22%Share
47Legal & General Group Plc41,164$10.0B2.22%Share
48Invesco Ltd.39,550$9.8B1.49%Share
49Aberdeen Group plc39,360$9.7B15.02%Share
50MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC37,269$9.0B94.61%Share

KRYS Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025332$4.1T+126
Q3 2025206$2.1T-29
Q2 2025235$1.9T-60
Q1 2025295$2.9T+42
Q4 2024253$5.2T+24
Q3 2024229$123.5T+30
Q2 2024199$130.0T+11
Q1 2024188$72.9T—

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As of Q4 2025, 50 institutional investors hold KRYS (Krystal Biotech, Inc.). The largest holder is FMR LLC with $814.0B in shares. This quarter, 3 institutions opened new positions and 5 closed their positions.

Frequently Asked Questions

How many hedge funds own KRYS?

As of Q4 2025, 50 institutional investors report holding KRYS (Krystal Biotech, Inc.) in their 13F filings.

Who is the largest institutional holder of KRYS?

The largest institutional holder of KRYS is FMR LLC with $814.0B in shares.

Is institutional ownership of KRYS increasing or decreasing?

This quarter, 3 institutions opened new positions in KRYS and 5 closed their positions.