| 1 | FEDERATED HERMES, INC. | 1,765,516 | $48.0M | 0.08% | Share |
| 2 | FRED ALGER MANAGEMENT, LLC | 1,460,971 | $39.0M | 0.15% | Share |
| 3 | JANUS HENDERSON GROUP PLC | 1,425,785 | $39.0M | 0.02% | Share |
| 4 | ORBIMED ADVISORS LLC | 1,196,955 | $32.6M | 0.67% | Share |
| 5 | Affinity Asset Advisors, LLC | 989,490 | $27.0M | 1.54% | Share |
| 6 | VANGUARD GROUP INC | 510,188 | $13.9M | 0.00% | Share |
| 7 | Point72 Asset Management, L.P. | 487,275 | $13.0M | 0.01% | Share |
| 8 | Cable Car Capital, LP | 400,000 | $10.9M | 0.36% | Share |
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 333,333 | $9.0M | 0.01% | Share |
| 10 | Woodline Partners LP | 331,987 | $9.0M | 0.03% | Share |
| 11 | Ikarian Capital, LLC | 300,000 | $8.2M | 0.64% | Share |
| 12 | FMR LLC | 310,965 | $8.0M | 0.00% | Share |
| 13 | AWM Investment Company, Inc. | 236,821 | $6.5M | 0.62% | Share |
| 14 | MILLENNIUM MANAGEMENT LLC | 246,685 | $6.0M | 0.00% | Share |
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 185,869 | $5.1M | 0.98% | Share |
| 16 | Jain Global LLC | 202,433 | $5.0M | 0.02% | Share |
| 17 | AMERIPRISE FINANCIAL INC | 153,027 | $4.0M | 0.00% | Share |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 100,646 | $2.0M | 0.00% | Share |
| 19 | VANGUARD GROUP INC | 67,575 | $1.8M | 0.00% | Share |
| 20 | J. Goldman & Co LP | 60,800 | $1.7M | 0.04% | Share |
| 21 | 683 Capital Management, LLC | 40,000 | $1.1M | 0.05% | Share |
| 22 | BlackRock, Inc. | 37,617 | $1.0M | 0.00% | Share |
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,914 | $1.0M | 0.00% | Share |
| 24 | MORGAN STANLEY | 54,837 | $1.0M | 0.00% | Share |
| 25 | STATE STREET CORP | 50,721 | $1.0M | 0.00% | Share |
| 26 | GOLDMAN SACHS GROUP INC | 68,023 | $1.0M | 0.00% | Share |
| 27 | UBS Group AG | 23,903 | $651K | 0.00% | Share |
| 28 | Affinity Asset Advisors, LLC | 22,400 | $610K | 0.03% | Call |
| 29 | Trexquant Investment LP | 12,916 | $352K | 0.00% | Share |
| 30 | Persistent Asset Partners Ltd | 10,146 | $276K | 0.12% | Share |
| 31 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 8,226 | $224K | 0.02% | Share |
| 32 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 4,568 | $124K | 0.01% | Share |
| 33 | VANGUARD GROUP INC | 4,500 | $122K | 0.00% | Share |
| 34 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 3,010 | $82K | 0.01% | Share |
| 35 | UBS Group AG | 921 | $25K | 0.00% | Share |
| 36 | GROUP ONE TRADING LLC | 300 | $8K | 0.00% | Put |
| 37 | GROUP ONE TRADING LLC | 204 | $5K | 0.00% | Share |
| 38 | COMERICA BANK | 150 | $4K | 0.00% | Share |
| 39 | ASSETMARK, INC | 58 | $1K | 0.00% | Share |
| 40 | ALPS ADVISORS INC | 10,289 | $0 | 0.00% | Share |
| 41 | JANE STREET GROUP, LLC | 1,917 | $0 | 0.00% | Share |
| 42 | JANE STREET GROUP, LLC | 6,427 | $0 | 0.00% | Share |
| 43 | Steward Partners Investment Advisory, LLC | 553 | $0 | 0.00% | Share |
| 44 | GEODE CAPITAL MANAGEMENT, LLC | 23,963 | $0 | 0.00% | Share |
| 45 | MARSHALL WACE, LLP | 4,406 | $0 | 0.00% | Share |
| 46 | MARSHALL WACE, LLP | 31,891 | $0 | 0.00% | Share |
| 47 | TWO SIGMA INVESTMENTS, LP | 31,808 | $0 | 0.00% | Share |
| 48 | AlphaQuest LLC | 18,804 | $0 | 0.00% | Share |
| 49 | SBI Securities Co., Ltd. | 12 | $0 | 0.00% | Share |
| 50 | WELLS FARGO & COMPANY/MN | 502 | $0 | 0.00% | Share |