| 1 | Cormorant Asset Management, LP | 2,344,971 | $19.1M | 0.88% | Share |
| 2 | ORBIMED ADVISORS LLC | 1,597,287 | $13.0M | 0.27% | Share |
| 3 | Aberdeen Group plc | 1,321,750 | $10.8M | 0.02% | Share |
| 4 | Octagon Capital Advisors LP | 955,000 | $7.8M | 0.94% | Share |
| 5 | VANGUARD GROUP INC | 758,471 | $6.2M | 0.00% | Share |
| 6 | CITADEL ADVISORS LLC | 843,193 | $6.0M | 0.00% | Share |
| 7 | Prosight Management, LP | 683,872 | $5.6M | 1.15% | Share |
| 8 | ARMISTICE CAPITAL, LLC | 536,000 | $4.4M | 0.05% | Share |
| 9 | Stonepine Capital Management, LLC | 389,916 | $3.2M | 2.32% | Share |
| 10 | ADAR1 Capital Management, LLC | 286,781 | $2.3M | 0.17% | Share |
| 11 | RENAISSANCE TECHNOLOGIES LLC | 354,300 | $2.0M | 0.00% | Share |
| 12 | COMERICA BANK | 200,001 | $1.6M | 0.01% | Share |
| 13 | Assenagon Asset Management S.A. | 187,956 | $1.5M | 0.00% | Share |
| 14 | Exome Asset Management LLC | 139,543 | $1.1M | 0.54% | Share |
| 15 | BALYASNY ASSET MANAGEMENT L.P. | 133,311 | $1.0M | 0.00% | Share |
| 16 | BlackRock, Inc. | 201,485 | $1.0M | 0.00% | Share |
| 17 | AMERIPRISE FINANCIAL INC | 135,304 | $1.0M | 0.00% | Share |
| 18 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 182,062 | $1.0M | 0.00% | Share |
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 227,826 | $1.0M | 0.00% | Share |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 137,945 | $1.0M | 0.00% | Share |
| 21 | Atle Fund Management AB | 107,255 | $873K | 0.28% | Share |
| 22 | VANGUARD GROUP INC | 96,241 | $783K | 0.00% | Share |
| 23 | 683 Capital Management, LLC | 85,543 | $696K | 0.03% | Share |
| 24 | Caption Management, LLC | 56,066 | $456K | 0.00% | Share |
| 25 | UBS Group AG | 49,747 | $404K | 0.00% | Share |
| 26 | BRC Group Holdings, Inc. | 38,714 | $315K | 0.13% | Share |
| 27 | Trexquant Investment LP | 27,275 | $222K | 0.00% | Share |
| 28 | Laurion Capital Management LP | 18,600 | $151K | 0.00% | Share |
| 29 | Pale Fire Capital SE | 18,650 | $151K | 0.01% | Share |
| 30 | SHERBROOKE PARK ADVISERS LLC | 15,410 | $125K | 0.32% | Share |
| 31 | Velan Capital Investment Management LP | 13,000 | $105K | 0.06% | Share |
| 32 | Virtu Financial LLC | 10,760 | $88K | 0.00% | Share |
| 33 | Persistent Asset Partners Ltd | 6,587 | $53K | 0.02% | Share |
| 34 | GROUP ONE TRADING LLC | 6,586 | $53K | 0.00% | Share |
| 35 | GROUP ONE TRADING LLC | 5,300 | $43K | 0.00% | Call |
| 36 | Avanza Fonder AB | 4,868 | $39K | 0.00% | Share |
| 37 | VANGUARD GROUP INC | 4,695 | $38K | 0.00% | Share |
| 38 | UBS Group AG | 1,157 | $9K | 0.00% | Share |
| 39 | JTC Employer Solutions Trustee Ltd | 1,106 | $9K | 0.00% | Share |
| 40 | Optiver Holding B.V. | 929 | $7K | 0.00% | Share |
| 41 | Versant Capital Management, Inc | 601 | $4K | 0.00% | Share |
| 42 | GROUP ONE TRADING LLC | 400 | $3K | 0.00% | Put |
| 43 | GAMMA Investing LLC | 386 | $3K | 0.00% | Share |
| 44 | UBS Group AG | 305 | $2K | 0.00% | Share |
| 45 | NISA INVESTMENT ADVISORS, LLC | 287 | $2K | 0.00% | Share |
| 46 | CWM, LLC | 149 | $1K | 0.00% | Share |
| 47 | EverSource Wealth Advisors, LLC | 135 | $1K | 0.00% | Share |
| 48 | DIMENSIONAL FUND ADVISORS LP | 71,032 | $0 | 0.00% | Share |
| 49 | DIMENSIONAL FUND ADVISORS LP | 1,456 | $0 | 0.00% | Share |
| 50 | DIMENSIONAL FUND ADVISORS LP | 4,866 | $0 | 0.00% | Share |