Who Owns Amylyx Pharmaceuticals, Inc. (AMLX)?Hedge Fund & Institutional Holders

$14.45+0.46 (+3.29%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

Infinity%

QoQ Change in Holders

+5 / -3

Price History

$2.94$6.44$9.93$13.43$16.92Sep 24Jun 25Mar 26

AMLX — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
FMR LLCIncreased+5.1M+$196.8B
JANUS HENDERSON GROUP PLCIncreased+1.9M+$18.5B
BANK OF AMERICA CORP /DE/Increased+906K+$15.0B
FRANKLIN RESOURCES INCNew Position+1.2M+$14.0B
Commodore Capital LPIncreased+1.6M+$12.9B
Sofinnova Investments, Inc.New Position+527K+$6.4B
FEDERATED HERMES, INC.New Position+457K+$5.0B
DRIEHAUS CAPITAL MANAGEMENT LLCIncreased+689K+$4.7B
AMERIPRISE FINANCIAL INCIncreased+369K+$4.2B
STEMPOINT CAPITAL LPIncreased+288K+$3.1B
TWO SIGMA INVESTMENTS, LPIncreased+246K+$2.7B
HighVista Strategies LLCNew Position+239K+$2.0B
XTX Topco LtdNew Position+190K+$2.0B
RENAISSANCE TECHNOLOGIES LLCIncreased+173K+$1.7B
GOLDMAN SACHS GROUP INCIncreased+603K+$1.7B

AMLX — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
ADAGE CAPITAL PARTNERS GP, L.L.C.Decreased-4.0M-$59.6B
Point72 Asset Management, L.P.Decreased-2.5M-$33.9B
Paradigm Biocapital Advisors LPClosed Position-1.9M-$25.8B
PERCEPTIVE ADVISORS LLCDecreased-667K-$21.6B
UBS Group AGDecreased-861K-$12.5B
ORBIMED ADVISORS LLCClosed Position-751K-$10.2B
BALYASNY ASSET MANAGEMENT L.P.Decreased-618K-$10.1B
Invesco Ltd.Decreased-635K-$8.9B
Saturn V Capital Management LPDecreased-108K-$8.3B
Logos Global Management LPDecreased-500K-$8.2B
Ally Bridge Group (NY) LLCClosed Position-437K-$5.9B
MILLENNIUM MANAGEMENT LLCDecreased-371K-$5.7B
First Light Asset Management, LLCDecreased-343-$5.1B
PFM Health Sciences, LPDecreased-302K-$4.3B
683 Capital Management, LLCDecreased-110K-$4.0B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1FMR LLC14,459,661$174.0B8.87%Share
2PERCEPTIVE ADVISORS LLC8,284,882$100.1B1783.88%Share
3TCG Crossover Management, LLC6,243,812$75.4B2.50%Share
4Commodore Capital LP5,650,000$68.3B4.54%Share
5Saturn V Capital Management LP4,496,487$54.3B9.97%Share
6JANUS HENDERSON GROUP PLC4,427,272$53.0B23.73%Share
7First Light Asset Management, LLC3,355,539$40.5B3.10%Share
8DRIEHAUS CAPITAL MANAGEMENT LLC3,109,503$37.6B255.14%Share
9ADAGE CAPITAL PARTNERS GP, L.L.C.2,777,055$33.0B49.94%Share
10GREAT POINT PARTNERS LLC1,750,000$21.1B6.85%Share
11683 Capital Management, LLC1,650,000$19.9B0.87%Share
12EVENTIDE ASSET MANAGEMENT, LLC1,513,148$18.3B285.52%Share
13DEUTSCHE BANK AG\1,331,987$16.0B5.21%Share
14GOLDMAN SACHS GROUP INC1,305,406$15.0B1.85%Share
15FMR LLC1,302,853$15.0B0.76%Share
16FRANKLIN RESOURCES INC1,200,059$14.0B3.43%Share
17Connor, Clark & Lunn Investment Management Ltd.1,004,021$12.0B31.47%Share
18BANK OF AMERICA CORP /DE/1,074,869$12.0B0.87%Share
19Logos Global Management LP950,000$11.5B0.69%Share
20ADAR1 Capital Management, LLC890,356$10.8B0.78%Share
21Nantahala Capital Management, LLC835,684$10.1B0.33%Share
22NORTHERN TRUST CORP868,235$10.0B1.27%Share
23BALYASNY ASSET MANAGEMENT L.P.858,684$10.0B12.69%Share
24GOLDMAN SACHS GROUP INC894,702$10.0B1.23%Share
25Woodline Partners LP845,408$10.0B38.75%Share
26Boxer Capital Management, LLC800,000$9.7B2.12%Share
27CHARLES SCHWAB INVESTMENT MANAGEMENT INC712,990$8.0B1.24%Share
28DIMENSIONAL FUND ADVISORS LP685,899$8.0B1.68%Share
29STEMPOINT CAPITAL LP565,140$6.8B1.17%Share
30UBS Group AG541,844$6.5B1.06%Share
31Sofinnova Investments, Inc.527,099$6.4B0.27%Share
32SILVERARC CAPITAL MANAGEMENT, LLC506,242$6.1B0.85%Share
33Rock Springs Capital Management LP499,764$6.0B0.31%Share
34AMERIPRISE FINANCIAL INC502,366$6.0B1.36%Share
35FEDERATED HERMES, INC.434,195$5.0B8.35%Share
36FMR LLC467,921$5.0B0.25%Share
37Cormorant Asset Management, LP400,000$4.8B0.22%Share
38Patient Square Capital LP350,000$4.2B0.91%Share
39GOLDMAN SACHS GROUP INC413,113$4.0B0.49%Share
40Point72 Asset Management, L.P.335,000$4.0B4.47%Share
41CITADEL ADVISORS LLC335,391$4.0B0.60%Share
42TWO SIGMA INVESTMENTS, LP344,401$4.0B5.64%Share
43BARCLAYS PLC295,177$3.0B0.72%Share
44Nuveen, LLC263,515$3.0B0.79%Share
45BANK OF AMERICA CORP /DE/251,172$3.0B0.22%Share
46FMR LLC287,899$3.0B0.15%Share
47TWO SIGMA ADVISERS, LP328,401$3.0B5.83%Share
48SummitTX Capital, L.P.218,399$2.6B0.08%Share
49Aldebaran Capital, LLC198,508$2.4B2.15%Share
50GROUP ONE TRADING LLC198,500$2.4B4.18%Call

AMLX Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025177$992.7B+36
Q3 2025141$992.7B+34
Q2 2025107$361.8B-28
Q1 2025135$232.1B+16
Q4 2024119$143.1B+23
Q3 202496$1.7T-9
Q2 2024105$1.4T-22
Q1 2024127$705.1T—

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As of Q4 2025, 50 institutional investors hold AMLX (Amylyx Pharmaceuticals, Inc.). The largest holder is FMR LLC with $174.0B in shares. This quarter, 5 institutions opened new positions and 3 closed their positions.

Frequently Asked Questions

How many hedge funds own AMLX?

As of Q4 2025, 50 institutional investors report holding AMLX (Amylyx Pharmaceuticals, Inc.) in their 13F filings.

Who is the largest institutional holder of AMLX?

The largest institutional holder of AMLX is FMR LLC with $174.0B in shares.

Is institutional ownership of AMLX increasing or decreasing?

This quarter, 5 institutions opened new positions in AMLX and 3 closed their positions.