Opaleye Management Inc. Q4 2025 Filing
Filed February 17, 2026
Portfolio Value
$758.0M
Holdings
54
Report Date
Q4 2025
Filing Type
13F-HR
All Holdings (54 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | HROWHARROW HEALTH INC | 3,905,000 | $191.3M | 25.24% | |
| 2 | LQDALIQUIDIA CORPORATION | 2,435,000 | $85.0M | 11.21% | |
| 3 | ETONETON PHARMACEUTICALS INC | 2,860,000 | $48.4M | 6.38% | |
| 4 | RYTMRHYTHM PHARMACEUTICALS INC | 330,000 | $35.3M | 4.66% | |
| 5 | APGEAPOGEE THERAPEUTICS INC | 388,257 | $29.3M | 3.87% | |
| 6 | SNWVSANUWAVE HEALTH INC | 981,267 | $29.3M | 3.86% | |
| 7 | STOKSTOKE THERAPEUTICS INC | 695,000 | $22.1M | 2.91% | |
| 8 | OCULOCULAR THERAPEUTIX INC | 1,595,000 | $19.4M | 2.55% | |
| 9 | SLGLSOL GEL TECHNOLOGIES | 453,739 | $19.1M | 2.52% | |
| 10 | CGONCG ONCOLOGY INC | 410,000 | $17.0M | 2.25% | |
| 11 | TGTXTG THERAPEUTICS INC | 535,000 | $15.9M | 2.10% | |
| 12 | IRONDISC MEDICINE INC | 200,000 | $15.9M | 2.10% | |
| 13 | RZLTREZOLUTE INC | 6,287,156 | $14.8M | 1.96% | |
| 14 | CBIOCRESCENT BIOPHARMA INC | 1,178,300 | $14.0M | 1.84% | |
| 15 | ALKSALKERMES PLC | 490,000 | $13.7M | 1.81% | |
| 16 | ACOGALPHA COGNITION INC | 2,070,784 | $13.5M | 1.78% | |
| 17 | ANNXANNEXON INC | 2,600,000 | $13.1M | 1.72% | |
| 18 | EWTXEDGEWISE THERAPEUTICS INC | 500,000 | $12.4M | 1.64% | |
| 19 | CDXSCODEXIS INC | 6,789,738 | $11.1M | 1.46% | |
| 20 | PTGXPROTAGONIST THERAPEUTICS INC | 105,000 | $9.2M | 1.21% | |
| 21 | GOSSGOSSAMER BIO INC | 2,720,000 | $8.4M | 1.11% | |
| 22 | MBXMBX BIOSCIENCES INC | 260,000 | $8.2M | 1.08% | |
| 23 | RVMDREVOLUTION MEDICINES INC | 100,000 | $8.0M | 1.05% | |
| 24 | XOMAXOMA CORP DEL | 292,590 | $7.8M | 1.03% | |
| 25 | DERMJOURNEY MEDICAL CORP | 975,000 | $7.5M | 0.99% | |
| 26 | KPTIKARYOPHARM THERAPEUTICS INC | 930,000 | $6.8M | 0.90% | |
| 27 | JBIOJADE BIOSCIENCES INC | 427,608 | $6.6M | 0.87% | |
| 28 | URGNUROGEN PHARMA LTD | 268,423 | $6.3M | 0.83% | |
| 29 | ALMSALUMIS INC | 535,000 | $5.2M | 0.69% | |
| 30 | CATXPERSPECTIVE THERAPEUTICS INC | 1,184,500 | $5.0M | 0.66% | |
| 31 | VYGRVOYAGER THERAPEUTICS INC | 1,196,904 | $4.7M | 0.62% | |
| 32 | RLMDRELMADA THERAPEUTICS INC | 935,000 | $4.5M | 0.60% | |
| 33 | TECXTECTONIC THERAPEUTICS INC | 214,747 | $4.5M | 0.59% | |
| 34 | PLXPROTALIX BIOTHERAPEUTICS INC | 2,478,176 | $4.5M | 0.59% | |
| 35 | TRVITREVI THERAPEUTICS INC | 345,100 | $4.3M | 0.57% | |
| 36 | FBIOFORTRESS BIOTECH INC | 1,090,000 | $4.0M | 0.53% | |
| 37 | RCKTROCKET PHARMACEUTICALS INC | 955,000 | $3.4M | 0.44% | |
| 38 | MGTXMEIRAGTX HOLDINGS PLC | 390,844 | $3.1M | 0.41% | |
| 39 | RI2RIGEL PHARMACEUTICALS INC | 70,000 | $3.0M | 0.40% | |
| 40 | ZYMEZYMEWORKS INC | 108,929 | $2.9M | 0.38% | |
| 41 | ASRTASSERTIO HOLDINGS INC | 285,000 | $2.6M | 0.34% | |
| 42 | VTYXVENTYX BIOSCIENCES INC | 251,932 | $2.3M | 0.30% | |
| 43 | IRDOPUS GENETICS INC | 1,120,000 | $2.3M | 0.30% | |
| 44 | STROSUTRO BIOPHARMA INC | 190,671 | $2.2M | 0.29% | |
| 45 | CABACABALETTA BIO INC | 900,000 | $2.0M | 0.26% | |
| 46 | ZNTLZENTALIS PHARMACEUTICALS INC | 1,400,906 | $1.9M | 0.25% | |
| 47 | GBIOGENERATION BIO CO | 310,000 | $1.8M | 0.23% | |
| 48 | BBIOBRIDGEBIO PHARMA INC | 18,319 | $1.4M | 0.18% | |
| 49 | ENTAENANTA PHARMACEUTICALS INC | 75,000 | $1.2M | 0.16% | |
| 50 | QTTBQ32 BIO INC | 213,363 | $708K | 0.09% | |
| 51 | AVIRATEA PHARMACEUTICALS INC | 179,815 | $641K | 0.08% | |
| 52 | SLNSILENCE THERAPEUTICS PLC | 78,926 | $479K | 0.06% | |
| 53 | RAPTRAPT THERAPEUTICS INC | 150,000 | $213K | 0.03% | |
| 54 | ADGMADAGIO MED HLDGS INC | 110,571 | $114K | 0.02% |