| 1 | FMR LLC | 2,836,622 | $33.0M | 0.00% | Share |
| 2 | BVF INC/IL | 2,748,763 | $32.6M | 1.10% | Share |
| 3 | Fairmount Funds Management LLC | 2,747,866 | $32.6M | 2.48% | Share |
| 4 | VR Adviser, LLC | 2,133,576 | $25.3M | 1.25% | Share |
| 5 | FCPM III SERVICES B.V. | 1,677,852 | $19.9M | 2.61% | Share |
| 6 | Vestal Point Capital, LP | 1,500,000 | $17.8M | 0.60% | Share |
| 7 | FMR LLC | 1,296,892 | $15.0M | 0.00% | Share |
| 8 | Opaleye Management Inc. | 1,178,300 | $14.0M | 1.84% | Share |
| 9 | TANG CAPITAL MANAGEMENT LLC | 872,398 | $10.3M | 0.51% | Share |
| 10 | ADAR1 Capital Management, LLC | 606,000 | $7.2M | 0.52% | Share |
| 11 | Logos Global Management LP | 600,000 | $7.1M | 0.43% | Share |
| 12 | VANGUARD GROUP INC | 504,614 | $6.0M | 0.00% | Share |
| 13 | Deep Track Capital, LP | 453,686 | $5.4M | 0.10% | Share |
| 14 | PERCEPTIVE ADVISORS LLC | 453,686 | $5.4M | 0.10% | Share |
| 15 | Boxer Capital Management, LLC | 453,686 | $5.4M | 1.18% | Share |
| 16 | RTW INVESTMENTS, LP | 372,856 | $4.4M | 0.04% | Share |
| 17 | NEXTBio Capital Management LP | 372,856 | $4.4M | 2.59% | Share |
| 18 | Remedium Capital Partners, LLC | 361,250 | $4.3M | 2.52% | Share |
| 19 | DRIEHAUS CAPITAL MANAGEMENT LLC | 302,457 | $3.6M | 0.02% | Share |
| 20 | HEIGHTS CAPITAL MANAGEMENT, INC | 264,000 | $3.1M | 1.12% | Share |
| 21 | Point72 Asset Management, L.P. | 300,000 | $3.0M | 0.00% | Share |
| 22 | Alyeska Investment Group, L.P. | 264,000 | $3.0M | 0.01% | Share |
| 23 | PRICE T ROWE ASSOCIATES INC /MD/ | 329,825 | $3.0M | 0.00% | Share |
| 24 | Stonepine Capital Management, LLC | 87,682 | $1.0M | 0.76% | Share |
| 25 | WELLINGTON MANAGEMENT GROUP LLP | 111,316 | $1.0M | 0.00% | Share |
| 26 | TWO SIGMA INVESTMENTS, LP | 125,224 | $1.0M | 0.00% | Share |
| 27 | BALYASNY ASSET MANAGEMENT L.P. | 111,715 | $1.0M | 0.00% | Share |
| 28 | BlackRock, Inc. | 109,152 | $1.0M | 0.00% | Share |
| 29 | Blackstone Inc. | 75,614 | $896K | 0.00% | Share |
| 30 | Burkehill Global Management, LP | 74,000 | $844K | 0.06% | Share |
| 31 | VANGUARD GROUP INC | 49,423 | $586K | 0.00% | Share |
| 32 | MOORE CAPITAL MANAGEMENT, LP | 25,000 | $296K | 0.00% | Share |
| 33 | UBS Group AG | 6,486 | $76K | 0.00% | Share |
| 34 | VANGUARD GROUP INC | 3,469 | $41K | 0.00% | Share |
| 35 | UBS Group AG | 639 | $7K | 0.00% | Share |
| 36 | SBI Securities Co., Ltd. | 68 | $0 | 0.00% | Share |
| 37 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,300 | $0 | 0.00% | Share |
| 38 | BANK OF AMERICA CORP /DE/ | 62 | $0 | 0.00% | Share |
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 4,406 | $0 | 0.00% | Share |
| 40 | WELLINGTON MANAGEMENT GROUP LLP | 27,690 | $0 | 0.00% | Share |
| 41 | OMERS ADMINISTRATION Corp | 11,600 | $0 | 0.00% | Share |
| 42 | BNP PARIBAS FINANCIAL MARKETS | 3,585 | $0 | 0.00% | Share |
| 43 | MORGAN STANLEY | 7,663 | $0 | 0.00% | Share |
| 44 | MORGAN STANLEY | 19,851 | $0 | 0.00% | Share |
| 45 | MORGAN STANLEY | 7 | $0 | 0.00% | Share |
| 46 | Tower Research Capital LLC (TRC) | 409 | $0 | 0.00% | Share |
| 47 | BlackRock, Inc. | 78 | $0 | 0.00% | Share |
| 48 | JPMORGAN CHASE & CO | 23,339 | $0 | 0.00% | Share |
| 49 | TWO SIGMA ADVISERS, LP | 32,500 | $0 | 0.00% | Share |
| 50 | Avion Wealth | 40 | $0 | 0.00% | Share |