Who Owns Protagonist Therapeutics, Inc. (PTGX)?Hedge Fund & Institutional Holders

$91.14-4.28 (-4.49%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$5.740005366174419e+254T

% of Float Held

Infinity%

QoQ Change in Holders

+14 / -4

Price History

$35.09$50.58$66.07$81.56$97.05Sep 24Jun 25Mar 26

PTGX — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.New Position+572K+$49.9M
Clearbridge Investments, LLCNew Position+490K+$42.0M
PRICE T ROWE ASSOCIATES INC /MD/Increased+180K+$40.9M
PRINCIPAL FINANCIAL GROUP INCNew Position+348K+$30.4M
JENNISON ASSOCIATES LLCNew Position+331K+$28.9M
Bank of New York Mellon CorpNew Position+350K+$28.0M
NEXTBio Capital Management LPNew Position+230K+$20.1M
Holocene Advisors, LPNew Position+210K+$18.0M
MPM BioImpact LLCNew Position+199K+$17.4M
Alyeska Investment Group, L.P.New Position+200K+$17.0M
AIHC Capital Management LtdNew Position+190K+$16.6M
NAN FUNG TRINITY (HK) LtdNew Position+181K+$15.8M
Qube Research & Technologies LtdNew Position+154K+$13.0M
Universal- Beteiligungs- und Servicegesellschaft mbHNew Position+114K+$10.0M
Hudson Bay Capital Management LPNew Position+110K+$9.0M

PTGX — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
FARALLON CAPITAL MANAGEMENT LLCDecreased-52K-$411.1B
RTW INVESTMENTS, LPDecreased-697K-$381.9B
BVF INC/ILClosed Position-2.6M-$170.1B
Deep Track Capital, LPClosed Position-1.7M-$114.0B
Woodline Partners LPDecreased-29K-$95.4B
DRIEHAUS CAPITAL MANAGEMENT LLCDecreased-41K-$75.6B
MARSHALL WACE, LLPDecreased-61K-$72.0B
Commodore Capital LPDecreased-575K-$68.1B
Pictet Asset Management Holding SADecreased-293K-$54.6B
Jefferies Financial Group Inc.Decreased-817K-$54.6B
ADAGE CAPITAL PARTNERS GP, L.L.C.Decreased-485K-$47.7B
Lynx1 Capital Management LPClosed Position-700K-$46.5B
NORTHERN TRUST CORPDecreased-28K-$40.0B
AMERICAN CENTURY COMPANIES INCDecreased-65K-$39.8B
MANGROVE PARTNERS IM, LLCClosed Position-478K-$31.8B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1BlackRock, Inc.6,583,297$574.0M0.01%Share
2FARALLON CAPITAL MANAGEMENT LLC6,144,006$536.6M2.53%Share
3RTW INVESTMENTS, LP5,059,053$441.9M4.43%Share
4VANGUARD GROUP INC4,940,686$431.5M0.01%Share
5STATE STREET CORP3,199,729$279.0M0.01%Share
6UBS Group AG2,763,785$241.4M0.04%Share
7WELLINGTON MANAGEMENT GROUP LLP2,572,660$224.0M0.04%Share
8JANUS HENDERSON GROUP PLC2,539,978$221.0M0.10%Share
9JOHNSON & JOHNSON2,449,183$213.9M38.57%Share
10BlackRock, Inc.1,740,228$151.0M0.00%Share
11Woodline Partners LP1,408,772$123.0M0.48%Share
12PERCEPTIVE ADVISORS LLC1,350,425$117.9M2.10%Share
13PRICE T ROWE ASSOCIATES INC /MD/1,341,653$117.0M0.01%Share
14GEODE CAPITAL MANAGEMENT, LLC1,264,263$110.0M0.01%Share
15DRIEHAUS CAPITAL MANAGEMENT LLC1,099,170$96.0M0.65%Share
16CITADEL ADVISORS LLC1,089,674$95.0M0.01%Share
17ADAR1 Capital Management, LLC1,049,168$91.6M6.63%Share
18Invesco Ltd.967,983$84.5M0.01%Share
19MARSHALL WACE, LLP809,682$70.0M0.06%Share
20BANK OF AMERICA CORP /DE/788,573$68.0M0.00%Share
21BlackRock, Inc.671,627$58.0M0.00%Share
22GOLDMAN SACHS GROUP INC654,697$57.0M0.01%Share
23Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.571,825$49.9M4.43%Share
24CHARLES SCHWAB INVESTMENT MANAGEMENT INC556,762$48.0M0.01%Share
25Invesco Ltd.539,224$47.1M0.01%Share
26FMR LLC539,067$47.0M0.00%Share
27Pictet Asset Management Holding SA529,631$46.3M0.04%Share
28AMERICAN CENTURY COMPANIES INC535,423$46.0M0.02%Share
29NORTHERN TRUST CORP495,155$43.0M0.01%Share
30Clearbridge Investments, LLC489,842$42.0M0.03%Share
31Commodore Capital LP450,000$39.3M2.62%Share
32VANGUARD GROUP INC405,721$35.4M0.00%Share
33683 Capital Management, LLC380,669$33.2M1.45%Share
34MORGAN STANLEY369,252$32.0M0.00%Share
35DIMENSIONAL FUND ADVISORS LP372,065$32.0M0.01%Share
36PRINCIPAL FINANCIAL GROUP INC344,493$30.1M0.02%Share
37SUSQUEHANNA INTERNATIONAL GROUP, LLP348,600$30.0M0.00%Call
38WELLINGTON MANAGEMENT GROUP LLP346,517$30.0M0.01%Share
39JENNISON ASSOCIATES LLC331,164$28.9M0.02%Share
40BNP Paribas Asset Management Holding S.A.330,118$28.0M0.03%Share
41GOLDMAN SACHS GROUP INC306,452$26.0M0.00%Share
42MORGAN STANLEY244,203$21.0M0.00%Share
43NEXTBio Capital Management LP229,619$20.1M11.76%Share
44ADAGE CAPITAL PARTNERS GP, L.L.C.232,836$20.0M0.03%Share
45KENNEDY CAPITAL MANAGEMENT LLC221,444$19.3M0.41%Share
46VOYA INVESTMENT MANAGEMENT LLC220,137$19.0M0.02%Share
47BlackRock, Inc.222,635$19.0M0.00%Share
48BlackRock, Inc.212,515$18.0M0.00%Share
49Holocene Advisors, LP210,019$18.0M0.04%Share
50MPM BioImpact LLC199,471$17.4M1.99%Share

PTGX Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025317$6.1B+98
Q3 2025219$4.4T-16
Q2 2025235$2.9T-35
Q1 2025270$3.0T+36
Q4 2024234$6.1T+37
Q3 2024197$1644.6T+37
Q2 2024160$904.3T+8
Q1 2024152$771.5T—

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As of Q4 2025, 50 institutional investors hold PTGX (Protagonist Therapeutics, Inc.). The largest holder is BlackRock, Inc. with $574.0M in shares. This quarter, 14 institutions opened new positions and 4 closed their positions.

Frequently Asked Questions

How many hedge funds own PTGX?

As of Q4 2025, 50 institutional investors report holding PTGX (Protagonist Therapeutics, Inc.) in their 13F filings.

Who is the largest institutional holder of PTGX?

The largest institutional holder of PTGX is BlackRock, Inc. with $574.0M in shares.

Is institutional ownership of PTGX increasing or decreasing?

This quarter, 14 institutions opened new positions in PTGX and 4 closed their positions.