Opaleye Management Inc.
CIK: 0001595855Latest portfolio: $758.0M · Q4 2025
Holdings
54
Total Value
$758.0M
New Positions
21
Closed Positions
10
Top Holdings
View All 54 Holdings →| # | Stock | Shares | Value | % Portfolio | Change | Type |
|---|---|---|---|---|---|---|
| 1 | HROWHARROW HEALTH INC | 3,905,000 | $191.3M | 25.24% | — | |
| 2 | LQDALIQUIDIA CORPORATION | 2,435,000 | $85.0M | 11.21% | -180,000 | |
| 3 | ETONETON PHARMACEUTICALS INC | 2,860,000 | $48.4M | 6.38% | — | |
| 4 | RYTMRHYTHM PHARMACEUTICALS INC | 330,000 | $35.3M | 4.66% | -131,700 | |
| 5 | APGEAPOGEE THERAPEUTICS INC | 388,257 | $29.3M | 3.87% | +25K | |
| 6 | SNWVSANUWAVE HEALTH INC | 981,267 | $29.3M | 3.86% | +1K | |
| 7 | STOKSTOKE THERAPEUTICS INC | 695,000 | $22.1M | 2.91% | +13K | |
| 8 | OCULOCULAR THERAPEUTIX INC | 1,595,000 | $19.4M | 2.55% | — | |
| 9 | SLGLSOL GEL TECHNOLOGIES | 453,739 | $19.1M | 2.52% | +249K | |
| 10 | CGONCG ONCOLOGY INC | 410,000 | $17.0M | 2.25% | — | |
| 11 | TGTXTG THERAPEUTICS INC | 535,000 | $15.9M | 2.10% | — | |
| 12 | IRONDISC MEDICINE INC | 200,000 | $15.9M | 2.10% | +6K | |
| 13 | RZLTREZOLUTE INC | 6,287,156 | $14.8M | 1.96% | +5.4M | |
| 14 | CBIOCRESCENT BIOPHARMA INC | 1,178,300 | $14.0M | 1.84% | NEW | |
| 15 | ALKSALKERMES PLC | 490,000 | $13.7M | 1.81% | +40K | |
| 16 | ACOGALPHA COGNITION INC | 2,070,784 | $13.5M | 1.78% | +2.0M | |
| 17 | ANNXANNEXON INC | 2,600,000 | $13.1M | 1.72% | — | |
| 18 | EWTXEDGEWISE THERAPEUTICS INC | 500,000 | $12.4M | 1.64% | — | |
| 19 | CDXSCODEXIS INC | 6,789,738 | $11.1M | 1.46% | -6,005,262 | |
| 20 | PTGXPROTAGONIST THERAPEUTICS INC | 105,000 | $9.2M | 1.21% | — | |
| 21 | GOSSGOSSAMER BIO INC | 2,720,000 | $8.4M | 1.11% | -5,000 | |
| 22 | MBXMBX BIOSCIENCES INC | 260,000 | $8.2M | 1.08% | +7K | |
| 23 | RVMDREVOLUTION MEDICINES INC | 100,000 | $8.0M | 1.05% | — | |
| 24 | XOMAXOMA CORP DEL | 292,590 | $7.8M | 1.03% | +38K | |
| 25 | DERMJOURNEY MEDICAL CORP | 975,000 | $7.5M | 0.99% | +4K |
Quarterly Changes
New Positions
Sector Breakdown
Healthcare0.0% ($1.9134584981483627e+212T)
Financial Services0.0% ($13.5M)
Unknown0.0% ($3.0M)
Filing History
Fund Information
Opaleye Management Inc. is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $758.0M across 54 holdings. The largest position is HARROW HEALTH INC (HROW), representing 25.2% of the portfolio. Compared to the previous quarter, the fund opened 21 new positions and closed 10 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.