RTW INVESTMENTS, LP Q4 2025 Filing
Filed February 17, 2026
Portfolio Value
$10.0B
Holdings
91
Report Date
Q4 2025
Filing Type
13F-HR
All Holdings (91 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | MDGLMADRIGAL PHARMACEUTICALS INC | 1,993,687 | $1.2B | 11.63% | |
| 2 | IM8NINSMED INC | 4,842,879 | $842.9M | 8.44% | |
| 3 | PTCTPTC THERAPEUTICS INC | 7,746,415 | $588.4M | 5.89% | |
| 4 | ARGXARGENX SE | 673,497 | $566.4M | 5.67% | |
| 5 | PTGXPROTAGONIST THERAPEUTICS INC | 5,059,053 | $441.9M | 4.43% | |
| 6 | NTRANATERA INC | 1,500,000 | $343.6M | 3.44% | |
| 7 | RDNTRADNET INC | 3,938,500 | $281.0M | 2.81% | |
| 8 | TARSTARSUS PHARMACEUTICALS INC | 3,335,320 | $273.1M | 2.74% | |
| 9 | COGTCOGENT BIOSCIENCES INC | 7,592,241 | $269.7M | 2.70% | |
| 10 | PENPENUMBRA INC | 866,499 | $269.4M | 2.70% | |
| 11 | IRTCIRHYTHM TECHNOLOGIES INC | 1,181,990 | $209.7M | 2.10% | |
| 12 | APGEAPOGEE THERAPEUTICS INC | 2,712,097 | $204.7M | 2.05% | |
| 13 | APLSAPELLIS PHARMACEUTICALS INC | 7,666,764 | $192.6M | 1.93% | |
| 14 | ACADACADIA PHARMACEUTICALS INC | 7,144,524 | $190.8M | 1.91% | |
| 15 | ESTAESTABLISHMENT LABS HLDGS INC | 2,588,831 | $188.7M | 1.89% | |
| 16 | STOKSTOKE THERAPEUTICS INC | 5,546,856 | $176.1M | 1.76% | |
| 17 | RGENREPLIGEN CORP | 1,064,000 | $174.3M | 1.75% | |
| 18 | CYTKCYTOKINETICS INC | 2,721,158 | $172.9M | 1.73% | |
| 19 | IMCRIMMUNOCORE HLDGS PLC | 4,869,798 | $169.0M | 1.69% | |
| 20 | AXSMAXSOME THERAPEUTICS INC | 888,001 | $162.2M | 1.62% | |
| 21 | GHGUARDANT HEALTH INC | 1,481,033 | $151.3M | 1.52% | |
| 22 | NBIXNEUROCRINE BIOSCIENCES INC | 1,062,072 | $150.6M | 1.51% | |
| 23 | SYRESPYRE THERAPEUTICS INC | 4,171,996 | $136.7M | 1.37% | |
| 24 | ZLABZAI LAB LTD | 6,959,032 | $122.8M | 1.23% | |
| 25 | IMTXIMMATICS N.V | 11,433,354 | $120.0M | 1.20% | |
| 26 | BLTEBELITE BIO INC | 715,332 | $114.4M | 1.15% | |
| 27 | URGNUROGEN PHARMA LTD | 4,543,895 | $106.4M | 1.07% | |
| 28 | XNCRXENCOR INC | 6,777,461 | $103.8M | 1.04% | |
| 29 | PODDINSULET CORP | 324,600 | $92.3M | 0.92% | |
| 30 | TSHATAYSHA GENE THERAPIES INC | 16,398,297 | $90.2M | 0.90% | |
| 31 | 3M4MASIMO CORP | 683,294 | $88.9M | 0.89% | |
| 32 | QUREUNIQURE NV | 3,711,462 | $88.8M | 0.89% | |
| 33 | SYKSTRYKER CORPORATION | 245,000 | $86.1M | 0.86% | |
| 34 | CGONCG ONCOLOGY INC | 2,012,127 | $83.5M | 0.84% | |
| 35 | CSTLCASTLE BIOSCIENCES INC | 2,115,237 | $82.3M | 0.82% | |
| 36 | IMVTIMMUNOVANT INC | 3,177,850 | $80.8M | 0.81% | |
| 37 | BBNXBETA BIONICS INC | 2,500,000 | $76.2M | 0.76% | |
| 38 | GHRSGH RESEARCH PLC | 5,933,815 | $75.4M | 0.75% | |
| 39 | REPLREPLIMUNE GROUP INC | 7,140,352 | $69.4M | 0.70% | |
| 40 | RAREULTRAGENYX PHARMACEUTICAL IN | 3,000,139 | $69.0M | 0.69% | |
| 41 | CRNXCRINETICS PHARMACEUTICALS IN | 1,351,326 | $62.9M | 0.63% | |
| 42 | ORKAORUKA THERAPEUTICS INC | 2,058,148 | $62.4M | 0.62% | |
| 43 | RCKTROCKET PHARMACEUTICALS INC | 17,687,772 | $62.1M | 0.62% | |
| 44 | CMPSCOMPASS PATHWAYS PLC | 8,757,390 | $60.4M | 0.61% | |
| 45 | ISRGINTUITIVE SURGICAL INC | 101,228 | $57.3M | 0.57% | |
| 46 | RAPTRAPT THERAPEUTICS INC | 1,637,165 | $55.5M | 0.56% | |
| 47 | CELCCELCUITY INC | 550,160 | $54.9M | 0.55% | |
| 48 | VSTMVERASTEM INC | 6,576,306 | $50.8M | 0.51% | |
| 49 | ALKSALKERMES PLC | 1,672,356 | $46.8M | 0.47% | |
| 50 | CNTACENTESSA PHARMACEUTICALS PLC | 1,790,837 | $44.8M | 0.45% | |
| 51 | KODKODIAK SCIENCES INC | 1,487,933 | $41.6M | 0.42% | |
| 52 | AQSTAQUESTIVE THERAPEUTICS INC | 6,250,000 | $40.4M | 0.40% | |
| 53 | ARWRARROWHEAD PHARMACEUTICALS IN | 584,716 | $38.8M | 0.39% | |
| 54 | YB4PSAVARA INC | 5,952,380 | $35.9M | 0.36% | |
| 55 | OBIOORCHESTRA BIOMED HLDGS INC | 8,306,063 | $34.5M | 0.35% | |
| 56 | NGNENEUROGENE INC | 1,362,456 | $28.1M | 0.28% | |
| 57 | WVEWAVE LIFE SCIENCES LTD | 1,350,000 | $22.9M | 0.23% | |
| 58 | JBIOJADE BIOSCIENCES INC | 1,449,273 | $22.4M | 0.22% | |
| 59 | EVMNEVOMMUNE INC | 1,283,671 | $22.0M | 0.22% | |
| 60 | KYMRKYMERA THERAPEUTICS INC | 240,000 | $18.7M | 0.19% | |
| 61 | FLGTFULGENT GENETICS INC | 705,027 | $18.5M | 0.19% | |
| 62 | CGEMCULLINAN THERAPEUTICS INC | 1,705,960 | $17.7M | 0.18% | |
| 63 | HNGEHINGE HEALTH INC | 353,500 | $16.4M | 0.16% | |
| 64 | BEAMBEAM THERAPEUTICS INC | 570,394 | $15.8M | 0.16% | |
| 65 | HTFLHEARTFLOW INC | 495,000 | $14.4M | 0.14% | |
| 66 | CMPXCOMPASS THERAPEUTICS INC | 2,500,000 | $13.4M | 0.13% | |
| 67 | TNGXTANGO THERAPEUTICS INC | 1,491,228 | $13.2M | 0.13% | |
| 68 | LMRILUMEXA IMAGING HOLDINGS INC | 650,000 | $12.0M | 0.12% | |
| 69 | LRMRLARIMAR THERAPEUTICS INC | 3,125,000 | $11.9M | 0.12% | |
| 70 | TEMTEMPUS AI INC | 200,000 | $11.8M | 0.12% | |
| 71 | KLRSKALARIS THERAPEUTICS INC | 1,300,000 | $11.0M | 0.11% | |
| 72 | IQVIQVIA HLDGS INC | 46,000 | $10.4M | 0.10% | |
| 73 | —PERCEPTIVE CAP SOLUTIONS COR | 742,500 | $9.7M | 0.10% | |
| 74 | ATAIATAI BECKLEY NV | 2,000,000 | $8.2M | 0.08% | |
| 75 | ALURALLURION TECHNOLOGIES INC | 5,891,430 | $7.2M | 0.07% | |
| 76 | CAPRCAPRICOR THERAPEUTICS INC | 250,000 | $7.2M | 0.07% | |
| 77 | GPCRSTRUCTURE THERAPEUTICS INC | 100,000 | $7.0M | 0.07% | |
| 78 | IVAINVENTIVA SA | 1,298,701 | $6.0M | 0.06% | |
| 79 | MISTMILESTONE PHARMACEUTICALS IN | 2,506,102 | $5.1M | 0.05% | |
| 80 | XGNEXAGEN INC | 790,462 | $4.8M | 0.05% | |
| 81 | TENXTENAX THERAPEUTICS INC | 378,346 | $4.6M | 0.05% | |
| 82 | CBIOCRESCENT BIOPHARMA INC. | 372,856 | $4.4M | 0.04% | |
| 83 | BRD1EURMIND MEDICINE MINDMED INC | 300,000 | $4.0M | 0.04% | |
| 84 | FDMT4D MOLECULAR THERAPEUTICS IN | 475,737 | $3.6M | 0.04% | |
| 85 | CRVSCORVUS PHARMACEUTICALS INC | 447,607 | $3.4M | 0.03% | |
| 86 | OMDAOMADA HEALTH INC | 200,000 | $3.2M | 0.03% | |
| 87 | MDLNMEDLINE INC | 70,000 | $2.9M | 0.03% | |
| 88 | IRONDISC MEDICINE INC | 30,000 | $2.4M | 0.02% | |
| 89 | IMAIMAGENEBIO INC | 334,445 | $2.3M | 0.02% | |
| 90 | ERASERASCA INC | 146,651 | $545K | 0.01% | |
| 91 | RCKTWROCKET PHARMACEUTICALS INC | 350,000 | $8K | 0.00% |