| 1 | RTW INVESTMENTS, LP | 2,115,237 | $82.3M | 0.82% | Share |
| 2 | VANGUARD GROUP INC | 1,979,313 | $77.0M | 0.00% | Share |
| 3 | PRINCIPAL FINANCIAL GROUP INC | 1,806,423 | $70.3M | 0.04% | Share |
| 4 | Portolan Capital Management, LLC | 1,729,463 | $67.3M | 3.60% | Share |
| 5 | BlackRock, Inc. | 1,398,762 | $54.0M | 0.00% | Share |
| 6 | DIMENSIONAL FUND ADVISORS LP | 1,101,177 | $42.0M | 0.01% | Share |
| 7 | SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 1,058,725 | $41.2M | 0.86% | Share |
| 8 | BlackRock, Inc. | 989,205 | $38.0M | 0.00% | Share |
| 9 | STATE STREET CORP | 736,454 | $28.0M | 0.00% | Share |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 619,689 | $24.0M | 0.00% | Share |
| 11 | Allianz Asset Management GmbH | 597,961 | $23.0M | 0.02% | Share |
| 12 | PALISADE CAPITAL MANAGEMENT, LP | 567,777 | $22.1M | 0.65% | Share |
| 13 | WASATCH ADVISORS LP | 537,241 | $20.9M | 0.12% | Share |
| 14 | SCHRODER INVESTMENT MANAGEMENT GROUP | 492,161 | $19.0M | 0.01% | Share |
| 15 | RENAISSANCE TECHNOLOGIES LLC | 493,100 | $19.0M | 0.03% | Share |
| 16 | AIGH Capital Management LLC | 455,443 | $17.7M | 4.29% | Share |
| 17 | ACADIAN ASSET MANAGEMENT LLC | 390,406 | $15.0M | 0.02% | Share |
| 18 | Connor, Clark & Lunn Investment Management Ltd. | 388,491 | $15.0M | 0.04% | Share |
| 19 | MILLENNIUM MANAGEMENT LLC | 308,914 | $12.0M | 0.01% | Share |
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 305,000 | $11.9M | 0.19% | Share |
| 21 | KORNITZER CAPITAL MANAGEMENT INC /KS | 267,733 | $10.4M | 0.22% | Share |
| 22 | Nuveen, LLC | 280,938 | $10.0M | 0.00% | Share |
| 23 | BlackRock, Inc. | 274,679 | $10.0M | 0.00% | Share |
| 24 | Advisors Capital Management, LLC | 250,677 | $9.8M | 0.11% | Share |
| 25 | NEW YORK STATE COMMON RETIREMENT FUND | 233,046 | $9.0M | 0.01% | Share |
| 26 | BANK OF AMERICA CORP /DE/ | 239,430 | $9.0M | 0.00% | Share |
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 242,535 | $9.0M | 0.00% | Share |
| 28 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 246,920 | $9.0M | 0.19% | Share |
| 29 | Qube Research & Technologies Ltd | 235,518 | $9.0M | 0.01% | Share |
| 30 | CITADEL ADVISORS LLC | 208,125 | $8.0M | 0.00% | Share |
| 31 | NORTHERN TRUST CORP | 231,146 | $8.0M | 0.00% | Share |
| 32 | VANGUARD GROUP INC | 181,663 | $7.1M | 0.00% | Share |
| 33 | SILVERCREST ASSET MANAGEMENT GROUP LLC | 205,002 | $7.0M | 0.05% | Share |
| 34 | BRAIDWELL LP | 177,183 | $6.9M | 0.22% | Share |
| 35 | AIGH Capital Management LLC | 169,276 | $6.6M | 1.59% | Share |
| 36 | Allspring Global Investments Holdings, LLC | 159,152 | $6.1M | 0.01% | Share |
| 37 | TUDOR INVESTMENT CORP ET AL | 167,178 | $6.0M | 0.01% | Share |
| 38 | GOLDMAN SACHS GROUP INC | 160,847 | $6.0M | 0.00% | Share |
| 39 | CITADEL ADVISORS LLC | 158,231 | $6.0M | 0.00% | Share |
| 40 | D. E. Shaw & Co., Inc. | 159,709 | $6.0M | 0.00% | Share |
| 41 | Parkman Healthcare Partners LLC | 150,558 | $5.9M | 0.56% | Share |
| 42 | UBS Group AG | 140,266 | $5.5M | 0.00% | Share |
| 43 | BNP PARIBAS FINANCIAL MARKETS | 150,011 | $5.0M | 0.00% | Share |
| 44 | BlackRock, Inc. | 135,956 | $5.0M | 0.00% | Share |
| 45 | MORGAN STANLEY | 135,461 | $5.0M | 0.00% | Share |
| 46 | Nuveen, LLC | 134,841 | $5.0M | 0.00% | Share |
| 47 | Invesco Ltd. | 119,176 | $4.6M | 0.00% | Share |
| 48 | Point72 Asset Management, L.P. | 119,458 | $4.0M | 0.00% | Share |
| 49 | Empowered Funds, LLC | 121,920 | $4.0M | 0.03% | Share |
| 50 | GOLDMAN SACHS GROUP INC | 126,388 | $4.0M | 0.00% | Share |