RTW INVESTMENTS, LP
CIK: 0001493215Latest portfolio: $10.0B · Q4 2025
Holdings
91
Total Value
$10.0B
New Positions
29
Closed Positions
12
Top Holdings
View All 91 Holdings →| # | Stock | Shares | Value | % Portfolio | Change | Type |
|---|---|---|---|---|---|---|
| 1 | MDGLMADRIGAL PHARMACEUTICALS INC | 1,993,687 | $1.2B | 11.63% | — | |
| 2 | IM8NINSMED INC | 4,842,879 | $842.9M | 8.44% | +1.8M | |
| 3 | PTCTPTC THERAPEUTICS INC | 7,746,415 | $588.4M | 5.89% | — | |
| 4 | ARGXARGENX SE | 673,497 | $566.4M | 5.67% | — | |
| 5 | PTGXPROTAGONIST THERAPEUTICS INC | 5,059,053 | $441.9M | 4.43% | -697,224 | |
| 6 | NTRANATERA INC | 1,500,000 | $343.6M | 3.44% | -500,000 | |
| 7 | RDNTRADNET INC | 3,938,500 | $281.0M | 2.81% | +1.1M | |
| 8 | TARSTARSUS PHARMACEUTICALS INC | 3,335,320 | $273.1M | 2.74% | +158K | |
| 9 | COGTCOGENT BIOSCIENCES INC | 7,592,241 | $269.7M | 2.70% | +4.1M | |
| 10 | PENPENUMBRA INC | 866,499 | $269.4M | 2.70% | — | |
| 11 | IRTCIRHYTHM TECHNOLOGIES INC | 1,181,990 | $209.7M | 2.10% | NEW | |
| 12 | APGEAPOGEE THERAPEUTICS INC | 2,712,097 | $204.7M | 2.05% | — | |
| 13 | APLSAPELLIS PHARMACEUTICALS INC | 7,666,764 | $192.6M | 1.93% | NEW | |
| 14 | ACADACADIA PHARMACEUTICALS INC | 7,144,524 | $190.8M | 1.91% | — | |
| 15 | ESTAESTABLISHMENT LABS HLDGS INC | 2,588,831 | $188.7M | 1.89% | — | |
| 16 | STOKSTOKE THERAPEUTICS INC | 5,546,856 | $176.1M | 1.76% | +423K | |
| 17 | RGENREPLIGEN CORP | 1,064,000 | $174.3M | 1.75% | NEW | |
| 18 | CYTKCYTOKINETICS INC | 2,721,158 | $172.9M | 1.73% | — | |
| 19 | IMCRIMMUNOCORE HLDGS PLC | 4,869,798 | $169.0M | 1.69% | — | |
| 20 | AXSMAXSOME THERAPEUTICS INC | 888,001 | $162.2M | 1.62% | -230,882 | |
| 21 | GHGUARDANT HEALTH INC | 1,481,033 | $151.3M | 1.52% | — | |
| 22 | NBIXNEUROCRINE BIOSCIENCES INC | 1,062,072 | $150.6M | 1.51% | — | |
| 23 | SYRESPYRE THERAPEUTICS INC | 4,171,996 | $136.7M | 1.37% | +550K | |
| 24 | ZLABZAI LAB LTD | 6,959,032 | $122.8M | 1.23% | +4.7M | |
| 25 | IMTXIMMATICS N.V | 11,433,354 | $120.0M | 1.20% | +2.6M |
Quarterly Changes
New Positions
Increased Positions
Sector Breakdown
HealthcareNaN% ($InfinityT)
Unknown0.0% ($842854888693589.3T)
Technology0.0% ($8K)
Filing History
| Quarter | Filing Date | Portfolio Value | Holdings |
|---|---|---|---|
| Q4 2025 | Feb 17, 2026 | $10.0B | 91 |
| Q3 2025 | Nov 14, 2025 | $8.1T | 74 |
| Q2 2025 | Aug 14, 2025 | $7.0T | 73 |
| Q1 2025 | May 15, 2025 | $6.5T | 68 |
| Q4 2024 | Feb 14, 2025 | $6.6T | 72 |
| Q3 2024 | Nov 14, 2024 | $6911.1T | 68 |
| Q2 2024 | Aug 14, 2024 | $6459.2T | 68 |
| Q1 2024 | May 15, 2024 | $6774.6T | 69 |
| Q4 2023 | Feb 14, 2024 | $6401.9T | 64 |
| Q3 2023 | Nov 14, 2023 | $4739.6T | 67 |
| Q2 2023 | Aug 14, 2023 | $5252.7T | 62 |
| Q1 2023 | May 15, 2023 | $4802.2T | 60 |
| Q4 2022 | Feb 14, 2023 | $4898.7T | 77 |
| Q3 2022 | Nov 14, 2022 | $4.3T | 86 |
| Q2 2022 | Aug 15, 2022 | $3.9T | 107 |
| Q1 2022 | May 16, 2022 | $4.8T | 106 |
| Q4 2021 | Feb 14, 2022 | $6.8T | 124 |
| Q3 2021 | Nov 15, 2021 | $6.6T | 120 |
| Q2 2021 | Aug 13, 2021 | $6.6T | 113 |
| Q1 2021 | May 14, 2021 | $6.4T | 111 |
| Q4 2020 | Feb 16, 2021 | $6.0T | 102 |
| Q3 2020 | Nov 16, 2020 | $4.2T | 90 |
| Q2 2020 | Aug 14, 2020 | $3.6T | 77 |
| Q1 2020 | May 15, 2020 | $2.3T | 65 |
| Q4 2019 | Feb 14, 2020 | $2.6T | 60 |
| Q3 2019 | Nov 14, 2019 | $1.7T | 60 |
| Q2 2019 | Aug 14, 2019 | $1.9T | 52 |
| Q1 2019 | May 15, 2019 | $1.5T | 50 |
| Q4 2018 | Feb 14, 2019 | $1.1T | 47 |
| Q3 2018 | Nov 14, 2018 | $1.7T | 46 |
| Q2 2018 | Aug 14, 2018 | $1.4T | 40 |
| Q1 2018 | May 14, 2018 | $1.1T | 38 |
| Q4 2017 | Feb 14, 2018 | $593.1B | 32 |
| Q3 2017 | Nov 14, 2017 | $574.2B | 27 |
| Q2 2017 | Aug 14, 2017 | $474.4B | 28 |
| Q1 2017 | May 15, 2017 | $379.9B | 28 |
| Q4 2016 | Feb 15, 2017 | $265.7B | 32 |
| Q3 2016 | Nov 14, 2016 | $330.9B | 36 |
| Q2 2016 | Aug 15, 2016 | $292.7B | 35 |
| Q1 2016 | May 11, 2016 | $275.4B | 34 |
Fund Information
RTW INVESTMENTS, LP is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $10.0B across 91 holdings. The largest position is MADRIGAL PHARMACEUTICALS INC (MDGL), representing 11.6% of the portfolio. Compared to the previous quarter, the fund opened 29 new positions and closed 12 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.