ORBIMED ADVISORS LLC Q4 2025 Filing
Filed February 17, 2026
Portfolio Value
$4.9B
Holdings
105
Report Date
Q4 2025
Filing Type
13F-HR
All Holdings (105 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | EWTXEDGEWISE THERAPEUTICS INC | 15,518,492 | $385.1M | 7.86% | |
| 2 | LLYELI LILLY & CO | 301,200 | $323.7M | 6.61% | |
| 3 | BSXBOSTON SCIENTIFIC CORP | 2,419,300 | $230.7M | 4.71% | |
| 4 | SVASINOVAC BIOTECH LTD | 2,718,735 | $184.5M | 3.77% | |
| 5 | EWEDWARDS LIFESCIENCES CORP | 1,992,900 | $169.9M | 3.47% | Call |
| 6 | UPBUPSTREAM BIO INC | 5,693,589 | $154.6M | 3.16% | |
| 7 | ISRGINTUITIVE SURGICAL INC | 263,400 | $149.2M | 3.04% | |
| 8 | SIONSIONNA THERAPEUTICS INC | 3,561,655 | $146.5M | 2.99% | |
| 9 | MBXMBX BIOSCIENCES INC | 3,935,203 | $124.1M | 2.53% | |
| 10 | ARGXARGENX SE | 146,000 | $122.8M | 2.51% | |
| 11 | ELVNENLIVEN THERAPEUTICS INC | 7,959,538 | $122.6M | 2.50% | |
| 12 | ALNYALNYLAM PHARMACEUTICALS INC | 288,800 | $114.8M | 2.34% | |
| 13 | SYKSTRYKER CORPORATION | 325,000 | $114.2M | 2.33% | |
| 14 | SPRYARS PHARMACEUTICALS INC | 8,288,510 | $96.6M | 1.97% | |
| 15 | TERNTERNS PHARMACEUTICALS INC | 2,153,300 | $87.0M | 1.78% | |
| 16 | IRONDISC MEDICINE INC | 1,067,550 | $84.8M | 1.73% | |
| 17 | CAICARIS LIFE SCIENCES INC | 3,116,011 | $84.1M | 1.72% | |
| 18 | NTRANATERA INC | 365,800 | $83.8M | 1.71% | |
| 19 | CMPXCOMPASS THERAPEUTICS INC | 15,219,994 | $81.7M | 1.67% | |
| 20 | GPCRSTRUCTURE THERAPEUTICS INC | 1,161,803 | $80.8M | 1.65% | |
| 21 | DHRDANAHER CORPORATION | 299,800 | $68.6M | 1.40% | |
| 22 | CGONCG ONCOLOGY INC | 1,516,550 | $63.0M | 1.29% | |
| 23 | APLSAPELLIS PHARMACEUTICALS INC | 2,429,868 | $61.0M | 1.25% | |
| 24 | AVBPARRIVENT BIOPHARMA INC | 3,027,328 | $60.9M | 1.24% | |
| 25 | CITHE CIGNA GROUP | 205,000 | $56.4M | 1.15% | |
| 26 | RAPTRAPT THERAPEUTICS INC | 1,642,891 | $55.6M | 1.14% | |
| 27 | CRVSCORVUS PHARMACEUTICALS INC | 7,165,006 | $55.2M | 1.13% | |
| 28 | UTHUNITED THERAPEUTICS CORP DEL | 105,200 | $51.3M | 1.05% | |
| 29 | ABVXABIVAX SA | 367,900 | $49.6M | 1.01% | |
| 30 | ROIVROIVANT SCIENCES LTD | 2,190,907 | $47.5M | 0.97% | |
| 31 | CRNXCRINETICS PHARMACEUTICALS IN | 999,000 | $46.5M | 0.95% | |
| 32 | AXSMAXSOME THERAPEUTICS INC | 253,121 | $46.2M | 0.94% | |
| 33 | EYPTEYEPOINT INC | 2,468,314 | $45.1M | 0.92% | |
| 34 | RNAAVIDITY BIOSCIENCES INC | 619,530 | $44.7M | 0.91% | |
| 35 | NBIXNEUROCRINE BIOSCIENCES INC | 314,240 | $44.6M | 0.91% | |
| 36 | DYNDYNE THERAPEUTICS INC | 2,202,184 | $43.1M | 0.88% | |
| 37 | BMYBRISTOL-MYERS SQUIBB CO | 775,000 | $41.8M | 0.85% | |
| 38 | PFEPFIZER INC | 1,652,900 | $41.2M | 0.84% | |
| 39 | TRVITREVI THERAPEUTICS INC | 3,190,700 | $39.9M | 0.82% | |
| 40 | NPCENEUROPACE INC | 2,406,335 | $37.2M | 0.76% | |
| 41 | ASNDASCENDIS PHARMA A/S | 171,977 | $36.7M | 0.75% | |
| 42 | EXASEXACT SCIENCES CORP | 351,716 | $35.7M | 0.73% | |
| 43 | MLYSMINERALYS THERAPEUTICS INC | 980,400 | $35.6M | 0.73% | |
| 44 | ELVELEVANCE HEALTH INC FORMERLY | 99,100 | $34.7M | 0.71% | |
| 45 | FBRXFORTE BIOSCIENCES INC | 1,196,955 | $32.6M | 0.67% | |
| 46 | PRLDPRELUDE THERAPEUTICS INC | 10,909,256 | $31.6M | 0.65% | |
| 47 | HELPCYBIN INC | 3,840,500 | $31.4M | 0.64% | |
| 48 | ORICORIC PHARMACEUTICALS INC | 3,641,756 | $29.8M | 0.61% | |
| 49 | KRYSKRYSTAL BIOTECH INC | 119,800 | $29.5M | 0.60% | |
| 50 | PRAXPRAXIS PRECISION MEDICINES I | 94,500 | $27.9M | 0.57% | |
| 51 | JANXJANUX THERAPEUTICS INC | 1,954,426 | $27.0M | 0.55% | |
| 52 | TMOTHERMO FISHER SCIENTIFIC INC | 46,500 | $26.9M | 0.55% | |
| 53 | BRKRBRUKER CORP | 555,789 | $26.2M | 0.53% | |
| 54 | RYTMRHYTHM PHARMACEUTICALS INC | 239,800 | $25.7M | 0.52% | |
| 55 | STTKSHATTUCK LABS INC | 6,306,127 | $23.0M | 0.47% | |
| 56 | ESPRESPERION THERAPEUTICS INC NE | 5,965,498 | $22.1M | 0.45% | |
| 57 | AVTXAVALO THERAPEUTICS INC | 1,187,300 | $21.6M | 0.44% | |
| 58 | LXEOLEXEO THERAPEUTICS INC | 2,125,000 | $21.1M | 0.43% | |
| 59 | ADCTADC THERAPEUTICS SA | 5,822,854 | $20.6M | 0.42% | |
| 60 | URGNUROGEN PHARMA LTD | 875,487 | $20.5M | 0.42% | |
| 61 | XENEXENON PHARMACEUTICALS INC | 447,200 | $20.0M | 0.41% | |
| 62 | BTSGBRIGHTSPRING HEALTH SVCS INC | 488,500 | $18.3M | 0.37% | |
| 63 | VERAVERA THERAPEUTICS INC | 353,500 | $17.9M | 0.37% | |
| 64 | QUREUNIQURE NV | 737,400 | $17.6M | 0.36% | |
| 65 | IMAPRELUDE THERAPEUTICS INC | 5,680,186 | $16.5M | 0.34% | |
| 66 | BRD1EURMIND MEDICINE MINDMED INC | 1,226,700 | $16.4M | 0.34% | |
| 67 | KROSKEROS THERAPEUTICS INC | 804,212 | $16.4M | 0.33% | |
| 68 | CARLCARLSMED INC | 1,252,600 | $15.5M | 0.32% | |
| 69 | CTMXCYTOMX THERAPEUTICS INC | 3,525,650 | $15.0M | 0.31% | |
| 70 | VIRVIR BIOTECHNOLOGY INC | 2,380,715 | $14.4M | 0.29% | |
| 71 | BCRXBIOCRYST PHARMACEUTICALS INC | 1,741,800 | $13.6M | 0.28% | |
| 72 | COGTCOGENT BIOSCIENCES INC | 371,000 | $13.2M | 0.27% | |
| 73 | CRBPCORBUS PHARMACEUTICALS HLDGS | 1,597,287 | $13.0M | 0.27% | |
| 74 | TARSTARSUS PHARMACEUTICALS INC | 154,400 | $12.6M | 0.26% | |
| 75 | RLMDRELMADA THERAPEUTICS INC | 2,610,600 | $12.6M | 0.26% | |
| 76 | TECXTECTONIC THERAPEUTIC INC | 574,600 | $12.0M | 0.24% | |
| 77 | ALMSALUMIS INC | 1,102,730 | $10.8M | 0.22% | |
| 78 | BIOABIOAGE LABS INC | 790,901 | $10.5M | 0.21% | |
| 79 | AM6AMICUS THERAPEUTICS INC | 729,900 | $10.4M | 0.21% | |
| 80 | WHWKWHITEHAWK THERAPEUTICS INC | 4,166,000 | $10.1M | 0.21% | |
| 81 | ACETADICET BIO INC | 1,027,944 | $8.7M | 0.18% | |
| 82 | RPTXREPARE THERAPEUTICS INC | 3,322,488 | $8.6M | 0.18% | |
| 83 | CELCCELCUITY INC | 85,664 | $8.5M | 0.17% | |
| 84 | JBIOJADE BIOSCIENCES INC | 531,163 | $8.2M | 0.17% | |
| 85 | KNSAKINIKSA PHARMACEUTICALS INTL | 187,199 | $7.7M | 0.16% | |
| 86 | QTTBQ32 BIO INC | 2,252,987 | $7.5M | 0.15% | |
| 87 | PMVPPMV PHARMACEUTICALS INC | 4,975,291 | $6.2M | 0.13% | |
| 88 | KALVKALVISTA PHARMACEUTICALS INC | 382,400 | $6.2M | 0.13% | |
| 89 | PHVSPHARVARIS N V | 205,400 | $5.7M | 0.12% | |
| 90 | NSPRINSPIREMD INC | 3,133,405 | $5.6M | 0.11% | |
| 91 | IM8NINSMED INC | 25,400 | $4.4M | 0.09% | |
| 92 | PALIPALISADE BIO INC | 1,871,420 | $4.4M | 0.09% | |
| 93 | IMAIMAGENEBIO INC | 530,713 | $3.7M | 0.07% | |
| 94 | BCAXBICARA THERAPEUTICS INC | 209,100 | $3.5M | 0.07% | |
| 95 | CGEMCULLINAN THERAPEUTICS INC | 270,006 | $2.8M | 0.06% | |
| 96 | CCCCC4 THERAPEUTICS INC | 1,404,902 | $2.7M | 0.05% | |
| 97 | IMAIMAGENEBIO INC | 378,556 | $2.6M | 0.05% | |
| 98 | ANROALTO NEUROSCIENCE INC | 125,000 | $2.2M | 0.05% | |
| 99 | RVMDREVOLUTION MEDICINES INC | 25,900 | $2.1M | 0.04% | |
| 100 | VTGNVISTAGEN THERAPEUTICS INC | 3,105,200 | $2.1M | 0.04% | Call |
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