ORBIMED ADVISORS LLC Q4 2024 Filing

Filed February 14, 2025

Portfolio Value

$4.9T

Holdings

112

Report Date

Q4 2024

Filing Type

13F-HR

All Holdings (112 positions)

#StockSharesValue% PortfolioType
1
EWTXEDGEWISE THERAPEUTICS INC
15,021,721$401.1B8.25%
2
SVASINOVAC BIOTECH LTD
2,718,735$334.0B6.87%
3
BSXBOSTON SCIENTIFIC CORP
3,160,300$282.3B5.81%
4
LLYELI LILLY & CO
337,600$260.6B5.36%
5
ISRGINTUITIVE SURGICAL INC
401,700$209.7B4.31%
6
ELVNENLIVEN THERAPEUTICS INC
7,959,538$179.1B3.68%
7
NBIXNEUROCRINE BIOSCIENCES INC
938,120$128.1B2.63%
8
SYKSTRYKER CORPORATION
344,400$124.0B2.55%
9
SRPTSAREPTA THERAPEUTICS INC
963,400$117.1B2.41%
10
ARGXARGENX SE
189,700$116.7B2.40%
11
IRONDISC MEDICINE INC
1,785,571$113.2B2.33%
12
THCTENET HEALTHCARE CORP
817,000$103.1B2.12%Call
13
ISIIONIS PHARMACEUTICALS INC
2,817,347$98.5B2.03%
14
ALNYALNYLAM PHARMACEUTICALS INC
415,600$97.8B2.01%
15
UPBUPSTREAM BIO INC
5,693,589$93.6B1.93%
16
SPRYARS PHARMACEUTICALS INC
8,288,510$87.4B1.80%
17
EWEDWARDS LIFESCIENCES CORP
1,145,302$84.8B1.74%
18
MRKMERCK & CO INC
829,900$82.6B1.70%
19
AVBPARRIVENT BIOPHARMA INC
3,027,328$80.6B1.66%
20
BIIBBIOGEN INC
509,100$77.9B1.60%
21
ITGRINTEGER HLDGS CORP
575,000$76.2B1.57%
22
CYTKCYTOKINETICS INC
1,584,005$74.5B1.53%
23
MBXMBX BIOSCIENCES INC
3,812,215$70.3B1.45%
24
UNHUNITEDHEALTH GROUP INC
130,900$66.2B1.36%
25
NTRANATERA INC
413,000$65.4B1.34%
26
VRTXVERTEX PHARMACEUTICALS INC
151,000$60.8B1.25%
27
THRDTHIRD HARMONIC BIO INC
5,779,071$59.5B1.22%
28
UHSUNIVERSAL HLTH SVCS INC
319,300$57.3B1.18%Call
29
SIBNSI-BONE INC
3,692,853$51.8B1.06%Call
30
CRNXCRINETICS PHARMACEUTICALS IN
999,000$51.1B1.05%
31
SWTXSPRINGWORKS THERAPEUTICS INC
1,255,031$45.3B0.93%
32
TMOTHERMO FISHER SCIENTIFIC INC
84,400$43.9B0.90%
33
TERNTERNS PHARMACEUTICALS INC
7,562,971$41.9B0.86%
34
GILDGILEAD SCIENCES INC
445,600$41.2B0.85%Call
35
CGONCG ONCOLOGY INC
1,431,114$41.0B0.84%
36
JANXJANUX THERAPEUTICS INC
758,566$40.6B0.84%
37
EXASEXACT SCIENCES CORP
679,816$38.2B0.79%
38
NPCENEUROPACE INC
3,406,335$38.1B0.78%
39
XENEXENON PHARMACEUTICALS INC
947,877$37.2B0.76%
40
CRVSCORVUS PHARMACEUTICALS INC
6,943,654$37.1B0.76%
41
XBISPDR SER TR
372,000$33.5B0.69%
42
CMPXCOMPASS THERAPEUTICS INC
22,362,850$32.4B0.67%
43
XTNTXTANT MED HLDGS INC
73,114,592$32.4B0.67%
44
RNAAVIDITY BIOSCIENCES INC
1,112,886$32.4B0.67%
45
VERAVERA THERAPEUTICS INC
742,572$31.4B0.65%
46
DYNDYNE THERAPEUTICS INC
1,227,080$28.9B0.59%
47
CGEMCULLINAN THERAPEUTICS INC
1,942,555$23.7B0.49%
48
VIRVIR BIOTECHNOLOGY INC
3,218,617$23.6B0.49%
49
RYTMRHYTHM PHARMACEUTICALS INC
400,000$22.4B0.46%
50
IMTXIMMATICS N.V
3,087,462$22.0B0.45%
51
GPCRSTRUCTURE THERAPEUTICS INC
802,028$21.8B0.45%Call
52
AM6AMICUS THERAPEUTICS INC
2,285,400$21.5B0.44%
53
SCPHSCPHARMACEUTICALS INC
6,059,528$21.5B0.44%
54
RAPTEURRAPT THERAPEUTICS INC
13,135,260$20.8B0.43%
55
TYRATYRA BIOSCIENCES INC
1,470,086$20.4B0.42%
56
MLYSMINERALYS THERAPEUTICS INC
1,611,637$19.8B0.41%
57
CCCCC4 THERAPEUTICS INC
4,527,900$16.3B0.34%Call
58
KROSKEROS THERAPEUTICS INC
1,018,734$16.1B0.33%
59
MEDPMEDPACE HLDGS INC
44,900$14.9B0.31%
60
VSTMVERASTEM INC
2,862,448$14.8B0.30%
61
PRLDPRELUDE THERAPEUTICS INC
10,909,256$13.9B0.29%
62
CRBPCORBUS PHARMACEUTICALS HLDGS
1,172,287$13.8B0.28%
63
FBRXFORTE BIOSCIENCES INC
600,000$13.6B0.28%
64
ITCIEURINTRA-CELLULAR THERAPIES INC
163,000$13.6B0.28%
65
SLRNACELYRIN INC
4,001,711$12.6B0.26%
66
ABCLABCELLERA BIOLOGICS INC
4,180,768$12.2B0.25%
67
ADCTADC THERAPEUTICS SA
5,968,451$11.9B0.24%
68
TORCEURADICET BIO INC
11,447,140$11.0B0.23%
69
IMAIKENA ONCOLOGY INC
6,368,587$10.4B0.21%
70
PMVPPMV PHARMACEUTICALS INC
6,475,291$9.8B0.20%
71
NMRANEUMORA THERAPEUTICS INC.
804,996$8.5B0.18%
72
QTTBQ32 BIO INC
2,252,987$7.8B0.16%
73
GONGERON CORP
2,168,000$7.7B0.16%
74
IMAPRELUDE THERAPEUTICS INC
5,680,186$7.2B0.15%
75
AVTXAVALO THERAPEUTICS INC
967,000$7.2B0.15%
76
CRDFCARDIFF ONCOLOGY INC
1,538,462$6.7B0.14%
77
PFEPFIZER INC
250,000$6.6B0.14%Call
78
SRRKSCHOLAR ROCK HLDG CORP
151,800$6.6B0.13%
79
IM8NINSMED INC
94,559$6.5B0.13%
80
ENGNENGENE HOLDINGS INC
920,339$6.1B0.13%
81
IKENA ONCOLOGY INC
3,539,358$5.8B0.12%
82
NSPRINSPIREMD INC
2,133,405$5.6B0.12%
83
TRAWTRAWS PHARMA INC
605,531$5.4B0.11%
84
BIOABIOAGE LABS INC
921,959$5.3B0.11%
85
ASNSUSDX4 PHARMACEUTICALS INC
7,133,515$5.2B0.11%
86
BCAXBICARA THERAPEUTICS INC
298,301$5.2B0.11%
87
MISTMILESTONE PHARMACEUTICALS IN
2,000,000$4.7B0.10%
88
RPTXREPARE THERAPEUTICS INC
3,322,488$4.4B0.09%
89
PASGPASSAGE BIO INC
7,404,869$4.2B0.09%
90
KRYSKRYSTAL BIOTECH INC
23,500$3.7B0.08%
91
ARDTARDENT HEALTH PARTNERS INC
206,000$3.5B0.07%
92
CMMBCHEMOMAB THERAPEUTICS LTD
1,741,273$3.2B0.06%
93
CBLLCERIBELL INC
112,500$2.9B0.06%
94
FATEFATE THERAPEUTICS INC
1,680,580$2.8B0.06%
95
PEPGPEPGEN INC
653,016$2.5B0.05%
96
TILINSTIL BIO INC
116,785$2.2B0.05%
97
NKTXNKARTA INC
821,400$2.0B0.04%
98
LYELLYELL IMMUNOPHARMA INC
3,103,623$2.0B0.04%
99
IMVTIMMUNOVANT INC
78,500$1.9B0.04%
100
AKROAKERO THERAPEUTICS INC
66,000$1.8B0.04%
Page 1 of 2Next