Opaleye Management Inc. Q3 2025 Filing
Filed November 14, 2025
Portfolio Value
$707.3M
Holdings
43
Report Date
Q3 2025
Filing Type
13F-HR
All Holdings (43 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | HROWHARROW HEALTH INC | 3,905,000 | $188.1M | 26.60% | |
| 2 | ETONETON PHARMACEUTICALS INC | 2,860,000 | $62.1M | 8.79% | |
| 3 | LQDALIQUIDIA CORPORATION | 2,615,000 | $59.5M | 8.41% | |
| 4 | RYTMRHYTHM PHARMACEUTICALS INC | 461,700 | $46.6M | 6.59% | |
| 5 | IMNMIMMUNOME INC | 3,185,000 | $37.3M | 5.27% | |
| 6 | SNWVSANUWAVE HEALTH INC | 980,000 | $36.7M | 5.19% | |
| 7 | CDXSCODEXIS INC | 12,795,000 | $31.2M | 4.41% | |
| 8 | TGTXTG THERAPEUTICS INC | 535,000 | $19.3M | 2.73% | |
| 9 | OCULOCULAR THERAPEUTIX INC | 1,595,000 | $18.6M | 2.64% | |
| 10 | CGONCG ONCOLOGY INC | 410,000 | $16.5M | 2.33% | |
| 11 | STOKSTOKE THERAPEUTICS INC | 682,017 | $16.0M | 2.27% | |
| 12 | APGEAPOGEE THERAPEUTICS INC | 363,257 | $14.4M | 2.04% | |
| 13 | ALKSALKERMES PLC | 450,000 | $13.5M | 1.91% | |
| 14 | IRONDISC MEDICINE INC | 193,773 | $12.8M | 1.81% | |
| 15 | SRPTSAREPTA THERAPEUTICS INC | 585,000 | $11.3M | 1.59% | |
| 16 | LRMRLARIMAR THERAPEUTICS INC | 3,720,867 | $10.6M | 1.49% | |
| 17 | XOMAXOMA CORP DEL | 255,087 | $9.8M | 1.39% | |
| 18 | RZLTREZOLUTE INC | 903,442 | $8.5M | 1.20% | |
| 19 | ARVNARVINAS INC | 987,818 | $8.4M | 1.19% | |
| 20 | EWTXEDGEWISE THERAPEUTICS INC | 500,000 | $8.1M | 1.15% | |
| 21 | ANNXANNEXON INC | 2,600,000 | $7.9M | 1.12% | |
| 22 | GOSSGOSSAMER BIO INC | 2,725,000 | $7.2M | 1.01% | |
| 23 | PTGXPROTAGONIST THERAPEUTICS INC | 105,000 | $7.0M | 0.99% | |
| 24 | DERMJOURNEY MEDICAL CORP | 971,064 | $6.9M | 0.98% | |
| 25 | SLGLSOL GEL TECHNOLOGIES | 204,835 | $6.0M | 0.84% | |
| 26 | PLXPROTALIX BIOTHERAPEUTICS INC | 2,580,556 | $5.7M | 0.81% | |
| 27 | TMCITREACE MEDICAL CONCEPTS INC | 702,245 | $4.7M | 0.67% | |
| 28 | RVMDREVOLUTION MEDICINES INC | 100,000 | $4.7M | 0.66% | |
| 29 | KPTI 3 10/15/25KARYOPHARM THERAPEUTICS INC | 6,000,000 | $4.6M | 0.65% | |
| 30 | MBXMBX BIOSCIENCES INC | 253,000 | $4.4M | 0.63% | |
| 31 | TRVITREVI THERAPEUTICS INC | 390,000 | $3.6M | 0.50% | |
| 32 | ADCTADC Therapeutics SA | 682,529 | $2.7M | 0.39% | |
| 33 | ALMSALUMIS INC | 665,000 | $2.7M | 0.38% | |
| 34 | CABACABALETTA BIO INC | 808,882 | $1.9M | 0.27% | |
| 35 | IRDOPUS GENETICS INC | 1,100,000 | $1.8M | 0.26% | |
| 36 | ZYMEZYMEWORKS INC | 100,000 | $1.7M | 0.24% | |
| 37 | SYRESPYRE THERAPEUTICS INC | 65,000 | $1.1M | 0.15% | |
| 38 | RI2RIGEL PHARMACEUTICALS | 37,787 | $1.1M | 0.15% | |
| 39 | ACOGALPHA COGNITION INC | 115,142 | $749K | 0.11% | |
| 40 | ZNTLZENTALIS PHARMACEUTICALS INC | 316,550 | $477K | 0.07% | |
| 41 | PEPGPEPGEN INC | 75,000 | $346K | 0.05% | |
| 42 | IBIOIBIO INC | 375,000 | $310K | 0.04% | |
| 43 | ADGMADAGIO MED HLDGS INC | 110,571 | $214K | 0.03% |