Opaleye Management Inc. Q1 2025 Filing

Filed May 15, 2025

Portfolio Value

$449.2M

Holdings

45

Report Date

Q1 2025

Filing Type

13F-HR

All Holdings (45 positions)

#StockSharesValue% PortfolioType
1
HROWHARROW HEALTH INC
3,955,000$105.2M23.42%
2
ETONETON PHARMACEUTICALS INC
2,852,070$37.0M8.24%
3
SNWVSANUWAVE HEALTH INC
972,002$34.4M7.65%
4
LQDALIQUIDIA CORPORATION
2,260,000$33.3M7.42%
5
RYTMRHYTHM PHARMACEUTICALS INC
490,000$26.0M5.78%
6
CDXSCODEXIS INC
9,500,000$25.6M5.69%
7
IMNMIMMUNOME INC
3,550,000$23.9M5.32%
8
TGTXTG THERAPEUTICS INC
535,000$21.1M4.70%
9
ARVNARVINAS INC
1,975,000$13.9M3.09%
10
OCULOCULAR THERAPEUTIX INC
1,595,000$11.7M2.60%
11
EWTXEDGEWISE THERAPEUTICS INC
395,000$8.7M1.93%
12
TARAPROTARA THERAPEUTICS INC
1,730,000$7.4M1.64%
13
DNAGINKGO BIOWORKS HOLDINGS
1,195,000$6.8M1.52%
14
GOSS 5 06/01/27GOSSAMER BIO INC
11,500,000$6.3M1.41%
15
ANIKANIKA THERAPEUTICS INC
395,000$5.9M1.32%
16
PTGXPROTAGONIST THERAPEUTICS INC
105,000$5.1M1.13%
17
XOMAXOMA CORP DEL
253,043$5.0M1.12%
18
TRVITREVI THERAPEUTICS INC
795,000$5.0M1.11%
19
PVLAPALVELLA THERAPEUTICS INC
172,357$4.8M1.07%
20
GOSSGOSSAMER BIO INC
4,287,415$4.7M1.05%
21
ANABANAPTYS BIO INC
250,933$4.7M1.04%
22
KPTI 3 10/15/25KARYOPHARM THERAPEUTICS INC
6,000,000$4.6M1.01%
23
IRONDISC MEDICINE INC
85,000$4.2M0.94%
24
LRMRLARIMAR THERAPEUTICS INC
1,914,077$4.1M0.92%
25
CGONCG ONCOLOGY INC
163,988$4.0M0.89%
26
SLRNACELYRIN INC
1,615,000$4.0M0.89%
27
RCELAVITA MEDICAL INC
440,000$3.6M0.80%
28
EPIEURESSA PHARMA INC
2,209,998$3.5M0.78%
29
ZNTLZENTALIS PHARMACEUTICALS INC
1,985,000$3.2M0.70%
30
CRGXCARGO THERAPEUTICS INC
666,503$2.7M0.60%
31
ZYMEZYMEWORKS INC
175,000$2.1M0.46%
32
BDSXBIODESIX INC
3,225,000$2.0M0.45%
33
STOKSTOKE THERAPEUTICS INC
300,000$2.0M0.44%
34
MBXMBX BIOSCIENCES INC
250,000$1.8M0.41%
35
0OPOPTINOSE INC
193,039$1.8M0.39%
36
IRDOPUS GENETICS INC
1,175,000$1.5M0.34%
37
IBIOIBIO INC
375,000$1.5M0.34%
38
KNSAKINIKSA PHARMACEUTICALS INTL
62,501$1.4M0.31%
39
NRIXNURIX THERAPEUTICS INC
115,000$1.4M0.30%
40
RZLTREZOLUTE INC
465,000$1.3M0.30%
41
GBYSANGAMO THERAPEUTICS INC
1,055,000$691K0.15%
42
PEPGPEPGEN INC
420,000$590K0.13%
43
DERMJOURNEY MEDICAL CORP
69,323$409K0.09%
44
VTYXVENTYX BIOSCIENCES INC
190,000$218K0.05%
45
ADGMADAGIO MED HLDGS INC
110,571$92K0.02%