BAKER BROS. ADVISORS LP Q4 2022 Filing

Filed February 14, 2023

Portfolio Value

$16.7B

Holdings

113

Report Date

Q4 2022

Filing Type

13F-HR

All Holdings (113 positions)

#StockSharesValue% PortfolioType
1
SGENUSDSeagen Inc.
46,912,266$6.0T36205.37%
2
INCYIncyte Corporation
36,154,971$2.9T17439.80%
3
ONCBeiGene, Ltd.
11,668,897$2.6T15412.88%
4
BMRNBioMarin Pharmaceutical Inc.
7,620,494$788.6B4736.21%
5
ACADACADIA Pharmaceuticals Inc.
41,923,486$667.4B4008.20%
6
ASNDAscendis Pharma A/S
4,954,855$605.1B3634.15%
7
MDGLMadrigal Pharmaceuticals, Inc.
1,545,113$448.5B2693.28%
8
RYTMRhythm Pharmaceuticals, Inc.
6,354,608$185.0B1111.30%
9
BCRXBioCryst Pharmaceuticals, Inc.
12,710,818$145.9B876.32%
10
IMCRImmunocore Holdings plc
2,520,731$143.9B863.94%
11
AKROAkero Therapeutics, Inc.
2,368,378$129.8B779.44%
12
REPLReplimune Group, Inc.
4,578,280$124.5B747.86%
13
KODKodiak Sciences Inc.
17,310,490$123.9B744.34%
14
HZNPHorizon Therapeutics Public Ltd Co
969,727$110.4B662.73%
15
ARGXargenx SE
280,159$106.1B637.38%
16
ABCLAbCellera Biologics Inc.
10,450,180$105.9B635.74%
17
KYMRKymera Therapeutics, Inc.
2,879,825$71.9B431.68%
18
290AChinook Therapeutics, Inc.
2,534,102$66.4B398.72%
19
TRDAEntrada Therapeutics, Inc.
4,865,819$65.8B395.07%
20
MRTXEURMirati Therapeutics, Inc.
1,409,784$63.9B383.61%
21
PRLDPrelude Therapeutics Inc.
10,123,824$61.1B367.22%
22
CERSCerus Corporation
16,067,558$58.6B352.20%
23
AVTEAerovate Therapeutics, Inc.
1,976,868$57.9B347.85%
24
1K0IGM Biosciences, Inc.
3,156,102$53.7B322.41%
25
IMTXImmatics N.V.
5,187,081$45.2B271.32%
26
NRIXNurix Therapeutics, Inc.
3,882,125$42.6B255.98%
27
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$41.9B251.85%
28
SWTXSpringWorks Therapeutics, Inc.
1,528,538$39.8B238.76%
29
IDYAIDEAYA Biosciences, Inc.
1,668,355$30.3B182.05%
30
DNLIDenali Therapeutics Inc.
1,088,738$30.3B181.83%
31
XENEXenon Pharmaceuticals Inc.
751,639$29.6B177.99%
32
VERVVerve Therapeutics, Inc.
1,416,530$27.4B164.60%
33
DICE Therapeutics, Inc.
862,207$26.9B161.55%
34
TVTXTravere Therapeutics, Inc.
1,225,255$25.8B154.74%
35
BCYCBicycle Therapeutics plc
843,814$25.0B149.99%
36
ANABAnaptysBio, Inc.
775,924$24.0B144.40%
37
KRYSKrystal Biotech, Inc.
302,716$24.0B144.02%
38
DBV Technologies S.A.
14,614,264$22.4B134.28%
39
FGENEURFibroGen, Inc.
1,375,211$22.0B132.30%
40
RAREUltragenyx Pharmaceutical Inc.
470,974$21.8B131.04%
41
HRTXHeron Therapeutics, Inc.
8,131,678$20.3B122.09%
42
TSVT*2seventy bio, Inc.
2,062,744$19.3B116.07%
43
INSM 0.75 06/01/28Insmed Incorporated
23,500,000$19.2B115.48%
44
PRMEPrime Medicine, Inc.
1,028,466$19.1B114.75%
45
BMEABiomea Fusion, Inc.
2,104,559$17.7B106.54%
46
bluebird bio, Inc.
2,499,715$17.3B103.88%
47
SPRYARS Pharmaceuticals, Inc.
2,006,451$17.1B102.78%
48
NVTA1EURInvitae Corporation
8,402,035$15.6B93.85%
49
OPTEYOpthea Limited
2,691,391$14.4B86.63%
50
ADAPYAdaptimmune Therapeutics plc
9,830,877$14.4B86.20%
51
CBAYUSDCymaBay Therapeutics, Inc.
2,170,464$13.6B81.72%
52
ZYMEZymeworks Inc.
1,708,472$13.4B80.64%
53
WHWKAadi Bioscience, Inc.
989,928$12.7B76.27%
54
CABACabaletta Bio, Inc.
1,344,000$12.4B74.66%
55
VSTMVerastem, Inc.
26,988,898$10.9B65.24%
56
ALTAltimmune, Inc.
653,562$10.8B64.57%
57
STOKStoke Therapeutics, Inc.
1,108,913$10.2B61.47%
58
CinCor Pharma, Inc.
807,212$9.9B59.57%
59
VORVor Biopharma Inc.
1,465,925$9.7B58.54%
60
RNAAvidity Biosciences, Inc.
434,782$9.6B57.94%
61
PACBPacific Biosciences of California, Inc.
1,127,782$9.2B55.40%
62
POINT Biopharma Global Inc.
1,169,103$8.5B51.18%
63
RETAEURReata Pharmaceuticals, Inc.
223,976$8.5B51.09%
64
SMMTSummit Therapeutics Inc.
2,000,000$8.5B51.05%
65
VERUEURVeru Inc.
1,609,579$8.5B51.03%
66
Affimed N.V.
6,596,830$8.2B49.13%
67
Invitae Corporation
10,300,000$8.1B48.39%
68
CMPXCompass Therapeutics, Inc.
1,557,630$7.8B47.05%
69
DSGNDesign Therapeutics, Inc.
692,131$7.1B42.65%
70
BHVNBiohaven Ltd.
476,190$6.6B39.69%
71
VERAVera Therapeutics, Inc.
333,333$6.4B38.73%
72
ALECAlector, Inc.
681,991$6.3B37.80%
73
MGNXMacroGenics, Inc.
892,579$6.0B35.97%
74
Athira Pharma, Inc.
1,879,836$6.0B35.79%
75
IPSCCentury Therapeutics, Inc.
1,149,340$5.9B35.41%
76
ROIVRoivant Sciences Ltd.
716,653$5.7B34.39%
77
TNGXTango Therapeutics, Inc.
750,000$5.4B32.65%
78
RVMDRevolution Medicines, Inc.
222,222$5.3B31.79%
79
EWTXEdgewise Therapeutics, Inc.
500,000$4.5B26.84%
80
PRAXPraxis Precision Medicines, Inc.
1,830,315$4.4B26.16%
81
TCRXTScan Therapeutics, Inc.
2,784,792$4.3B25.92%
82
VSAREURAravive, Inc.
3,261,224$4.3B25.85%
83
CYTCyteir Therapeutics, Inc.
2,492,118$4.1B24.69%
84
NTRANatera, Inc.
100,000$4.0B24.12%
85
Talis Biomedical Corporation
7,624,835$3.4B20.41%
86
TILInstil Bio, Inc.
5,273,789$3.3B19.95%
87
XNCRXencor, Inc.
123,127$3.2B19.25%
88
5E7iTeos Therapeutics, Inc.
150,346$2.9B17.63%
89
KALAKala Pharmaceuticals, Inc.
76,813$2.9B17.60%
90
BCELAtreca, Inc.
3,532,760$2.8B16.98%
91
HOOKGBPHOOKIPA Pharma Inc.
3,475,535$2.8B16.91%
92
PMVPPMV Pharmaceuticals, Inc.
322,024$2.8B16.82%
93
ATRAGBXAtara Biotherapeutics, Inc.
744,186$2.4B14.65%
94
NKTXNkarta, Inc.
400,000$2.4B14.39%
95
PCVXVaxcyte, Inc.
48,885$2.3B14.08%
96
698Achilles Therapeutics plc
2,591,366$2.3B14.00%
97
FATEFate Therapeutics, Inc.
215,695$2.2B13.07%
98
ALGSAligos Therapeutics, Inc.
2,076,400$2.0B11.88%
99
Neoleukin Therapeutics, Inc.
3,821,740$1.9B11.68%
100
KRON1USDKronos Bio, Inc.
1,198,151$1.9B11.66%
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