BAKER BROS. ADVISORS LP Q2 2023 Filing
Filed August 14, 2023
Portfolio Value
$17.3T
Holdings
107
Report Date
Q2 2023
Filing Type
13F-HR
All Holdings (107 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | SGENUSDSeagen Inc. | 44,554,162 | $8.6T | 49.63% | |
| 2 | INCYIncyte Corporation | 36,178,056 | $2.3T | 13.03% | |
| 3 | ONCBeiGene, Ltd. | 11,668,897 | $2.1T | 12.04% | |
| 4 | ACADACADIA Pharmaceuticals Inc. | 42,864,612 | $1.0T | 5.94% | |
| 5 | MDGLMadrigal Pharmaceuticals, Inc. | 1,545,113 | $356.9B | 2.07% | |
| 6 | BMRNBioMarin Pharmaceutical Inc. | 3,810,248 | $330.3B | 1.91% | |
| 7 | IMCRImmunocore Holdings plc | 2,520,731 | $151.1B | 0.87% | |
| 8 | —Invitae Corporation | 300,000,000 | $135.0B | 0.78% | |
| 9 | KODKodiak Sciences Inc. | 17,310,490 | $119.4B | 0.69% | |
| 10 | AKROAkero Therapeutics, Inc. | 2,368,378 | $110.6B | 0.64% | |
| 11 | ARGXargenx SE | 280,159 | $109.2B | 0.63% | |
| 12 | RYTMRhythm Pharmaceuticals, Inc. | 6,498,267 | $107.2B | 0.62% | |
| 13 | REPLReplimune Group, Inc. | 4,578,280 | $106.3B | 0.62% | |
| 14 | ABCLAbCellera Biologics Inc. | 16,450,180 | $106.3B | 0.62% | |
| 15 | KYMRKymera Therapeutics, Inc. | 4,375,340 | $100.6B | 0.58% | |
| 16 | ROIVRoivant Sciences Ltd. | 9,428,592 | $95.0B | 0.55% | |
| 17 | BCRXBioCryst Pharmaceuticals, Inc. | 12,710,818 | $89.5B | 0.52% | |
| 18 | SWTXSpringWorks Therapeutics, Inc. | 2,999,846 | $78.7B | 0.46% | |
| 19 | TRDAEntrada Therapeutics, Inc. | 4,865,819 | $73.7B | 0.43% | |
| 20 | RVMDRevolution Medicines, Inc. | 2,691,493 | $72.0B | 0.42% | |
| 21 | IMTXImmatics N.V. | 5,640,816 | $65.1B | 0.38% | |
| 22 | 290AChinook Therapeutics, Inc. | 1,455,202 | $55.9B | 0.32% | |
| 23 | MRTXEURMirati Therapeutics, Inc. | 1,409,784 | $50.9B | 0.29% | |
| 24 | —DICE Therapeutics, Inc. | 1,035,786 | $48.1B | 0.28% | |
| 25 | BMEABiomea Fusion, Inc. | 2,108,949 | $46.3B | 0.27% | |
| 26 | PRLDPrelude Therapeutics Inc. | 10,123,824 | $45.6B | 0.26% | |
| 27 | DNLIDenali Therapeutics Inc. | 1,455,322 | $42.9B | 0.25% | |
| 28 | KNSAKiniksa Pharmaceuticals, Ltd. | 2,809,577 | $39.6B | 0.23% | |
| 29 | CERSCerus Corporation | 16,067,558 | $39.5B | 0.23% | |
| 30 | NRIXNurix Therapeutics, Inc. | 3,882,125 | $38.8B | 0.22% | |
| 31 | RAREUltragenyx Pharmaceutical Inc. | 783,059 | $36.1B | 0.21% | |
| 32 | AVTEAerovate Therapeutics, Inc. | 1,963,479 | $33.7B | 0.19% | |
| 33 | 1K0IGM Biosciences, Inc. | 3,157,210 | $29.1B | 0.17% | |
| 34 | XENEXenon Pharmaceuticals Inc. | 751,639 | $28.9B | 0.17% | |
| 35 | IMGNEURImmunoGen, Inc. | 1,520,097 | $28.7B | 0.17% | |
| 36 | —DBV Technologies S.A. | 14,614,264 | $27.8B | 0.16% | |
| 37 | VERVVerve Therapeutics, Inc. | 1,416,530 | $26.6B | 0.15% | |
| 38 | TSVT*2seventy bio, Inc. | 2,497,526 | $25.3B | 0.15% | |
| 39 | IDYAIDEAYA Biosciences, Inc. | 1,062,123 | $25.0B | 0.14% | |
| 40 | STOKStoke Therapeutics, Inc. | 2,130,238 | $22.6B | 0.13% | |
| 41 | BCYCBicycle Therapeutics plc | 843,814 | $21.5B | 0.12% | |
| 42 | GLUEMonte Rosa Therapeutics, Inc. | 3,023,951 | $20.7B | 0.12% | |
| 43 | CABACabaletta Bio, Inc. | 1,594,000 | $20.6B | 0.12% | |
| 44 | KRYSKrystal Biotech, Inc. | 169,934 | $19.9B | 0.12% | |
| 45 | SMMTSummit Therapeutics Inc. | 6,304,705 | $15.8B | 0.09% | |
| 46 | ANABAnaptysBio, Inc. | 775,924 | $15.8B | 0.09% | |
| 47 | PRMEPrime Medicine, Inc. | 1,028,466 | $15.1B | 0.09% | |
| 48 | PACBPacific Biosciences of California, Inc. | 1,127,782 | $15.0B | 0.09% | |
| 49 | RLAYRelay Therapeutics, Inc. | 1,160,117 | $14.6B | 0.08% | |
| 50 | SPRYARS Pharmaceuticals, Inc. | 2,006,451 | $13.4B | 0.08% | |
| 51 | DAWNDay One Biopharmaceuticals, Inc. | 1,000,000 | $11.9B | 0.07% | |
| 52 | SANASana Biotechnology, Inc. | 2,000,000 | $11.9B | 0.07% | |
| 53 | COGTCogent Biosciences, Inc. | 979,600 | $11.6B | 0.07% | |
| 54 | —POINT Biopharma Global Inc. | 1,169,103 | $10.6B | 0.06% | |
| 55 | ADAPYAdaptimmune Therapeutics plc | 10,969,282 | $10.1B | 0.06% | |
| 56 | NVTA1EURInvitae Corporation | 8,881,104 | $10.0B | 0.06% | |
| 57 | VSTMVerastem, Inc. | 1,336,485 | $9.9B | 0.06% | |
| 58 | GONGeron Corporation | 3,061,224 | $9.8B | 0.06% | |
| 59 | HRTXHeron Therapeutics, Inc. | 8,131,678 | $9.4B | 0.05% | |
| 60 | —Athira Pharma, Inc. | 3,153,807 | $9.3B | 0.05% | |
| 61 | RNAAvidity Biosciences, Inc. | 799,451 | $8.9B | 0.05% | |
| 62 | —bluebird bio, Inc. | 2,499,715 | $8.2B | 0.05% | |
| 63 | FATEFate Therapeutics, Inc. | 1,671,717 | $8.0B | 0.05% | |
| 64 | ALLOAllogene Therapeutics, Inc. | 1,576,901 | $7.8B | 0.05% | |
| 65 | OPTEYOpthea Limited | 2,691,391 | $7.5B | 0.04% | |
| 66 | IM8NInsmed Incorporated | 343,000 | $7.2B | 0.04% | |
| 67 | TCRXTScan Therapeutics, Inc. | 2,784,792 | $7.0B | 0.04% | |
| 68 | WHWKAadi Bioscience, Inc. | 989,928 | $6.8B | 0.04% | |
| 69 | SERASera Prognostics, Inc. | 1,777,435 | $5.9B | 0.03% | |
| 70 | ALECAlector, Inc. | 964,851 | $5.8B | 0.03% | |
| 71 | CMPXCompass Therapeutics, Inc. | 1,557,630 | $5.0B | 0.03% | |
| 72 | NTRANatera, Inc. | 100,000 | $4.9B | 0.03% | |
| 73 | MGNXMacroGenics, Inc. | 892,579 | $4.8B | 0.03% | |
| 74 | MREOMereo BioPharma Group PLC | 3,554,979 | $4.7B | 0.03% | |
| 75 | VSAREURAravive, Inc. | 3,261,224 | $4.1B | 0.02% | |
| 76 | —Affimed N.V. | 6,596,830 | $3.9B | 0.02% | |
| 77 | HOOKGBPHOOKIPA Pharma Inc. | 4,425,535 | $3.9B | 0.02% | |
| 78 | EWTXEdgewise Therapeutics, Inc. | 500,000 | $3.9B | 0.02% | |
| 79 | GRCLGracell Biotechnologies Inc. | 1,000,000 | $3.8B | 0.02% | |
| 80 | CYPHLeap Therapeutics, Inc. | 1,172,175 | $3.7B | 0.02% | |
| 81 | TLISTalis Biomedical Corporation | 7,624,835 | $3.7B | 0.02% | |
| 82 | IPSCCentury Therapeutics, Inc. | 1,149,340 | $3.6B | 0.02% | |
| 83 | —Mersana Therapeutics, Inc. | 1,086,115 | $3.6B | 0.02% | |
| 84 | BCELAtreca, Inc. | 3,532,760 | $3.5B | 0.02% | |
| 85 | —Neoleukin Therapeutics, Inc. | 3,821,740 | $3.2B | 0.02% | |
| 86 | DSGNDesign Therapeutics, Inc. | 500,000 | $3.1B | 0.02% | |
| 87 | XNCRXencor, Inc. | 123,127 | $3.1B | 0.02% | |
| 88 | TILInstil Bio, Inc. | 5,273,789 | $2.9B | 0.02% | |
| 89 | TNGXTango Therapeutics, Inc. | 750,000 | $2.5B | 0.01% | |
| 90 | PCVXVaxcyte, Inc. | 48,885 | $2.4B | 0.01% | |
| 91 | 698Achilles Therapeutics plc | 2,557,149 | $2.4B | 0.01% | |
| 92 | VERAVera Therapeutics, Inc. | 146,464 | $2.4B | 0.01% | |
| 93 | PRAXPraxis Precision Medicines, Inc. | 1,879,915 | $2.2B | 0.01% | |
| 94 | ALGSAligos Therapeutics, Inc. | 2,076,400 | $2.0B | 0.01% | |
| 95 | PMVPPMV Pharmaceuticals, Inc. | 322,024 | $2.0B | 0.01% | |
| 96 | 5E7iTeos Therapeutics, Inc. | 150,346 | $2.0B | 0.01% | |
| 97 | VORVor Biopharma Inc. | 633,848 | $2.0B | 0.01% | |
| 98 | KALAKala Pharmaceuticals, Inc. | 116,213 | $1.7B | 0.01% | |
| 99 | ISREURPerspective Therapeutics, Inc. | 2,319,286 | $1.5B | 0.01% | |
| 100 | AGLEUSDAeglea BioTherapeutics, Inc. | 3,410,106 | $1.5B | 0.01% |
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