SPHERA FUNDS MANAGEMENT LTD. Q4 2025 Filing
Filed February 17, 2026
Portfolio Value
$517.3M
Holdings
98
Report Date
Q4 2025
Filing Type
13F-HR
All Holdings (98 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | TEVATEVA PHARMACEUTICAL INDS LTD | 1,123,525 | $35.1M | 6.78% | |
| 2 | BIIBBIOGEN INC | 94,738 | $16.7M | 3.22% | |
| 3 | MLYSMINERALYS THERAPEUTICS INC | 449,003 | $16.3M | 3.15% | |
| 4 | SNDXSYNDAX PHARMACEUTICALS INC | 762,563 | $16.0M | 3.10% | |
| 5 | NVMINOVA LTD | 47,846 | $15.7M | 3.04% | |
| 6 | RAREULTRAGENYX PHARMACEUTICAL IN | 650,623 | $15.0M | 2.89% | Call |
| 7 | TSEMTOWER SEMICONDUCTOR LTD | 122,513 | $14.4M | 2.78% | |
| 8 | COGTCOGENT BIOSCIENCES INC | 378,500 | $13.4M | 2.60% | |
| 9 | AZNASTRAZENECA PLC | 135,060 | $12.4M | 2.40% | |
| 10 | PRAXPRAXIS PRECISION MEDICINES I | 40,000 | $11.8M | 2.28% | Call |
| 11 | SNYSANOFI SA | 239,515 | $11.6M | 2.24% | |
| 12 | LLYELI LILLY & CO | 9,040 | $9.7M | 1.88% | |
| 13 | AM6AMICUS THERAPEUTICS INC | 658,377 | $9.4M | 1.81% | |
| 14 | IMTXIMMATICS N.V | 861,105 | $9.0M | 1.75% | |
| 15 | BMRNBIOMARIN PHARMACEUTICAL INC | 147,000 | $8.7M | 1.69% | |
| 16 | XBISPDR SERIES TRUST | 70,000 | $8.5M | 1.65% | Put |
| 17 | BBIOBRIDGEBIO PHARMA INC | 107,746 | $8.2M | 1.59% | |
| 18 | ORICORIC PHARMACEUTICALS INC | 1,004,378 | $8.2M | 1.59% | |
| 19 | DYNDYNE THERAPEUTICS INC | 392,894 | $7.7M | 1.49% | |
| 20 | TRVITREVI THERAPEUTICS INC | 598,534 | $7.5M | 1.45% | |
| 21 | JNJJOHNSON & JOHNSON | 35,831 | $7.4M | 1.43% | |
| 22 | YB4PSAVARA INC | 1,178,164 | $7.1M | 1.37% | |
| 23 | SRRKSCHOLAR ROCK HLDG CORP | 158,265 | $7.0M | 1.35% | |
| 24 | WVEWAVE LIFE SCIENCES LTD | 408,166 | $6.9M | 1.34% | |
| 25 | HELPCYBIN INC | 825,576 | $6.8M | 1.31% | |
| 26 | ANNXANNEXON INC | 1,316,212 | $6.6M | 1.28% | |
| 27 | BCRXBIOCRYST PHARMACEUTICALS INC | 837,889 | $6.5M | 1.26% | |
| 28 | TCE2CELLDEX THERAPEUTICS INC NEW | 239,764 | $6.5M | 1.26% | |
| 29 | SLNOSOLENO THERAPEUTICS INC | 136,314 | $6.3M | 1.22% | |
| 30 | APLSAPELLIS PHARMACEUTICALS INC | 250,961 | $6.3M | 1.22% | |
| 31 | NSYNICE LTD | 55,700 | $6.3M | 1.22% | Call |
| 32 | GSKGSK PLC | 122,000 | $6.0M | 1.16% | |
| 33 | ENPHENPHASE ENERGY INC | 186,500 | $6.0M | 1.16% | |
| 34 | NVONOVO-NORDISK A S | 115,677 | $5.9M | 1.14% | |
| 35 | CYTKCYTOKINETICS INC | 91,717 | $5.8M | 1.13% | |
| 36 | ABBVABBVIE INC | 25,256 | $5.8M | 1.12% | |
| 37 | SEDGSOLAREDGE TECHNOLOGIES INC | 196,536 | $5.7M | 1.10% | |
| 38 | ACADACADIA PHARMACEUTICALS INC | 212,202 | $5.7M | 1.10% | |
| 39 | VORVOR BIOPHARMA INC | 410,417 | $5.4M | 1.04% | |
| 40 | MRKMERCK & CO INC | 48,600 | $5.1M | 0.99% | |
| 41 | NVSNNOVARTIS AG | 37,000 | $5.1M | 0.99% | |
| 42 | FBRXFORTE BIOSCIENCES INC | 185,869 | $5.1M | 0.98% | |
| 43 | KODKODIAK SCIENCES INC | 175,500 | $4.9M | 0.95% | |
| 44 | TNGXTANGO THERAPEUTICS INC | 544,563 | $4.8M | 0.93% | |
| 45 | SEDG 2.25 07/01/29SOLAREDGE TECHNOLOGIES INC | 4,000,000 | $4.7M | 0.91% | |
| 46 | CATBUSDASTRIA THERAPEUTICS INC | 355,725 | $4.7M | 0.90% | |
| 47 | MDWDMEDIWOUND LTD | 230,347 | $4.3M | 0.82% | |
| 48 | CAMTCAMTEK LTD | 39,498 | $4.2M | 0.81% | |
| 49 | RVMDREVOLUTION MEDICINES INC | 52,500 | $4.2M | 0.81% | |
| 50 | TLTISHARES TR | 47,000 | $4.1M | 0.79% | Call |
| 51 | AMDADVANCED MICRO DEVICES INC | 18,040 | $3.9M | 0.75% | |
| 52 | CLYMCLIMB BIO INC | 932,247 | $3.7M | 0.72% | |
| 53 | ACOGALPHA COGNITION INC | 567,616 | $3.7M | 0.71% | |
| 54 | ELVNENLIVEN THERAPEUTICS INC | 226,765 | $3.5M | 0.68% | |
| 55 | TARAPROTARA THERAPEUTICS INC | 650,000 | $3.5M | 0.67% | |
| 56 | AVGOBROADCOM INC | 9,755 | $3.4M | 0.65% | |
| 57 | ELDNELEDON PHARMACEUTICALS INC | 2,132,131 | $3.2M | 0.62% | |
| 58 | BIOABIOAGE LABS INC | 243,035 | $3.2M | 0.62% | |
| 59 | CRVSCORVUS PHARMACEUTICALS INC | 407,709 | $3.1M | 0.61% | |
| 60 | ESLTELBIT SYS LTD | 5,340 | $3.1M | 0.60% | |
| 61 | KURAKURA ONCOLOGY INC | 295,522 | $3.1M | 0.59% | |
| 62 | MAZEMAZE THERAPEUTICS INC | 71,843 | $3.0M | 0.58% | |
| 63 | ZIMZIM INTEGRATED SHIPPING SERV | 136,005 | $2.9M | 0.56% | |
| 64 | GPCRSTRUCTURE THERAPEUTICS INC | 41,000 | $2.9M | 0.55% | |
| 65 | EVMNEVOMMUNE INC | 166,147 | $2.8M | 0.55% | |
| 66 | VSTMVERASTEM INC | 343,678 | $2.7M | 0.51% | |
| 67 | AMGNAMGEN INC | 7,500 | $2.5M | 0.47% | |
| 68 | NRIXNURIX THERAPEUTICS INC | 124,000 | $2.4M | 0.45% | |
| 69 | ASNDASCENDIS PHARMA A/S | 11,000 | $2.3M | 0.45% | |
| 70 | TENXTENAX THERAPEUTICS INC | 190,111 | $2.3M | 0.45% | |
| 71 | JANXJANUX THERAPEUTICS INC | 157,840 | $2.2M | 0.42% | |
| 72 | PFEPFIZER INC | 86,000 | $2.1M | 0.41% | |
| 73 | TSHATAYSHA GENE THERAPIES INC | 368,146 | $2.0M | 0.39% | |
| 74 | CTNMCONTINEUM THERAPEUTICS INC | 173,475 | $2.0M | 0.38% | |
| 75 | MDGLMADRIGAL PHARMACEUTICALS INC | 3,300 | $1.9M | 0.37% | |
| 76 | PHVSPHARVARIS N V | 63,953 | $1.8M | 0.34% | |
| 77 | VRNSVARONIS SYS INC | 52,500 | $1.7M | 0.33% | |
| 78 | DTILPRECISION BIOSCIENCES INC | 396,116 | $1.6M | 0.32% | |
| 79 | VTYXVENTYX BIOSCIENCES INC | 180,114 | $1.6M | 0.31% | |
| 80 | IBITISHARES BITCOIN TRUST ETF | 30,055 | $1.5M | 0.29% | |
| 81 | DAWNDAY ONE BIOPHARMACEUTICALS I | 145,371 | $1.4M | 0.26% | |
| 82 | VYGRVOYAGER THERAPEUTICS INC | 339,761 | $1.3M | 0.26% | |
| 83 | TRDAENTRADA THERAPEUTICS INC | 110,942 | $1.1M | 0.22% | |
| 84 | TNYATENAYA THERAPEUTICS INC | 1,500,000 | $1.1M | 0.21% | |
| 85 | CATXPERSPECTIVE THERAPEUTICS INC | 349,973 | $962K | 0.19% | |
| 86 | BMYBRISTOL-MYERS SQUIBB CO | 17,500 | $943K | 0.18% | |
| 87 | JSPRJASPER THERAPEUTICS INC | 485,401 | $888K | 0.17% | |
| 88 | PEPGPEPGEN INC | 121,467 | $790K | 0.15% | |
| 89 | STTKSHATTUCK LABS INC | 195,212 | $712K | 0.14% | |
| 90 | PALIPALISADE BIO INC | 184,100 | $432K | 0.08% | |
| 91 | HOWLWEREWOLF THERAPEUTICS INC | 626,810 | $397K | 0.08% | |
| 92 | SKYESKYE BIOSCIENCE INC | 478,928 | $359K | 0.07% | |
| 93 | PRLDPRELUDE THERAPEUTICS INC | 122,752 | $355K | 0.07% | |
| 94 | APREAPREA THERAPEUTICS INC | 270,000 | $230K | 0.04% | |
| 95 | OKURONKURE THERAPEUTICS INC | 60,454 | $175K | 0.03% | |
| 96 | MREOMEREO BIOPHARMA GROUP PLC | 255,400 | $106K | 0.02% | |
| 97 | PMNPROMIS NEUROSCIENCES INC | 11,807 | $80K | 0.02% | |
| 98 | APLTAPPLIED THERAPEUTICS INC | 50,000 | $5K | 0.00% |