| 1 | 5AM Venture Management, LLC | 9,681,763 | $7.3M | 2.28% | Share |
| 2 | Versant Venture Management, LLC | 2,007,704 | $1.5M | 1.00% | Share |
| 3 | BAKER BROS. ADVISORS LP | 1,450,638 | $1.1M | 0.01% | Share |
| 4 | VANGUARD GROUP INC | 773,999 | $580K | 0.00% | Share |
| 5 | SPHERA FUNDS MANAGEMENT LTD. | 478,928 | $359K | 0.07% | Share |
| 6 | VANGUARD GROUP INC | 104,229 | $78K | 0.00% | Share |
| 7 | Schonfeld Strategic Advisors LLC | 93,407 | $70K | 0.00% | Share |
| 8 | GROUP ONE TRADING LLC | 17,697 | $13K | 0.00% | Share |
| 9 | R Squared Ltd | 14,782 | $11K | 0.01% | Share |
| 10 | CAPITAL ADVISORS INC/OK | 10,000 | $7K | 0.00% | Share |
| 11 | GROUP ONE TRADING LLC | 8,800 | $6K | 0.00% | Call |
| 12 | UBS Group AG | 6,800 | $5K | 0.00% | Share |
| 13 | UBS Group AG | 6,458 | $4K | 0.00% | Share |
| 14 | VANGUARD GROUP INC | 4,557 | $3K | 0.00% | Share |
| 15 | SIMPLEX TRADING, LLC | 6,331 | $0 | 0.00% | Share |
| 16 | SIMPLEX TRADING, LLC | 2,600 | $0 | 0.00% | Put |
| 17 | Rockefeller Capital Management L.P. | 39 | $0 | 0.00% | Share |
| 18 | XTX Topco Ltd | 53,040 | $0 | 0.00% | Share |
| 19 | BARCLAYS PLC | 21,251 | $0 | 0.00% | Share |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 172,868 | $0 | 0.00% | Share |
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 37,283 | $0 | 0.00% | Share |
| 22 | PLATINUM INVESTMENT MANAGEMENT LTD | 233,095 | $0 | 0.00% | Share |
| 23 | ROYAL BANK OF CANADA | 117 | $0 | 0.00% | Share |
| 24 | ROYAL BANK OF CANADA | 7 | $0 | 0.00% | Share |
| 25 | TWO SIGMA INVESTMENTS, LP | 51,706 | $0 | 0.00% | Share |
| 26 | MILLENNIUM MANAGEMENT LLC | 380,478 | $0 | 0.00% | Share |
| 27 | CITADEL ADVISORS LLC | 64,700 | $0 | 0.00% | Call |
| 28 | CITADEL ADVISORS LLC | 18,000 | $0 | 0.00% | Put |
| 29 | TWO SIGMA ADVISERS, LP | 40,982 | $0 | 0.00% | Share |
| 30 | FMR LLC | 748 | $0 | 0.00% | Share |
| 31 | BANK OF AMERICA CORP /DE/ | 22 | $0 | 0.00% | Share |
| 32 | BANK OF AMERICA CORP /DE/ | 7 | $0 | 0.00% | Share |
| 33 | BANK OF AMERICA CORP /DE/ | 557 | $0 | 0.00% | Share |
| 34 | NORTHERN TRUST CORP | 20,142 | $0 | 0.00% | Share |
| 35 | NATIONAL BANK OF CANADA /FI/ | 400 | $0 | 0.00% | Share |
| 36 | BNP PARIBAS FINANCIAL MARKETS | 510 | $0 | 0.00% | Share |
| 37 | GSA CAPITAL PARTNERS LLP | 22,877 | $0 | 0.00% | Share |
| 38 | MORGAN STANLEY | 3,900 | $0 | 0.00% | Share |
| 39 | MORGAN STANLEY | 2 | $0 | 0.00% | Share |
| 40 | MORGAN STANLEY | 367 | $0 | 0.00% | Share |
| 41 | BlackRock, Inc. | 3,385 | $0 | 0.00% | Share |
| 42 | BlackRock, Inc. | 45,582 | $0 | 0.00% | Share |
| 43 | BlackRock, Inc. | 232,870 | $0 | 0.00% | Share |
| 44 | BlackRock, Inc. | 4 | $0 | 0.00% | Share |
| 45 | JPMORGAN CHASE & CO | 66 | $0 | 0.00% | Share |
| 46 | Optiver Holding B.V. | 20 | $0 | 0.00% | Share |
| 47 | GROUP ONE TRADING LLC | 500 | $0 | 0.00% | Put |
| 48 | HARBOUR INVESTMENTS, INC. | 1 | $0 | 0.00% | Share |
| 49 | Plante Moran Financial Advisors, LLC | 3 | $0 | 0.00% | Share |
| 50 | Dynamic Wealth Strategies, LLC | 8 | $0 | 0.00% | Share |