SPHERA FUNDS MANAGEMENT LTD.
CIK: 0001496201Latest portfolio: $517.3M · Q4 2025
Holdings
98
Total Value
$517.3M
New Positions
24
Closed Positions
31
Top Holdings
View All 98 Holdings →| # | Stock | Shares | Value | % Portfolio | Change | Type |
|---|---|---|---|---|---|---|
| 1 | TEVATEVA PHARMACEUTICAL INDS LTD | 1,123,525 | $35.1M | 6.78% | -383,500 | |
| 2 | BIIBBIOGEN INC | 94,738 | $16.7M | 3.22% | +12K | |
| 3 | MLYSMINERALYS THERAPEUTICS INC | 449,003 | $16.3M | 3.15% | +229K | |
| 4 | SNDXSYNDAX PHARMACEUTICALS INC | 762,563 | $16.0M | 3.10% | +375K | |
| 5 | NVMINOVA LTD | 47,846 | $15.7M | 3.04% | +4K | |
| 6 | RAREULTRAGENYX PHARMACEUTICAL IN | 650,623 | $15.0M | 2.89% | NEW | Call |
| 7 | TSEMTOWER SEMICONDUCTOR LTD | 122,513 | $14.4M | 2.78% | -189,289 | |
| 8 | COGTCOGENT BIOSCIENCES INC | 378,500 | $13.4M | 2.60% | +280K | |
| 9 | AZNASTRAZENECA PLC | 135,060 | $12.4M | 2.40% | — | |
| 10 | PRAXPRAXIS PRECISION MEDICINES I | 40,000 | $11.8M | 2.28% | -67,901 | Call |
| 11 | SNYSANOFI SA | 239,515 | $11.6M | 2.24% | +20K | |
| 12 | LLYELI LILLY & CO | 9,040 | $9.7M | 1.88% | -1,000 | |
| 13 | AM6AMICUS THERAPEUTICS INC | 658,377 | $9.4M | 1.81% | -332,765 | |
| 14 | IMTXIMMATICS N.V | 861,105 | $9.0M | 1.75% | +278K | |
| 15 | BMRNBIOMARIN PHARMACEUTICAL INC | 147,000 | $8.7M | 1.69% | NEW | |
| 16 | XBISPDR SERIES TRUST | 70,000 | $8.5M | 1.65% | NEW | Put |
| 17 | BBIOBRIDGEBIO PHARMA INC | 107,746 | $8.2M | 1.59% | NEW | |
| 18 | ORICORIC PHARMACEUTICALS INC | 1,004,378 | $8.2M | 1.59% | +573K | |
| 19 | DYNDYNE THERAPEUTICS INC | 392,894 | $7.7M | 1.49% | -33,624 | |
| 20 | TRVITREVI THERAPEUTICS INC | 598,534 | $7.5M | 1.45% | NEW | |
| 21 | JNJJOHNSON & JOHNSON | 35,831 | $7.4M | 1.43% | -5,000 | |
| 22 | YB4PSAVARA INC | 1,178,164 | $7.1M | 1.37% | -172,169 | |
| 23 | SRRKSCHOLAR ROCK HLDG CORP | 158,265 | $7.0M | 1.35% | NEW | |
| 24 | WVEWAVE LIFE SCIENCES LTD | 408,166 | $6.9M | 1.34% | +358K | |
| 25 | HELPCYBIN INC | 825,576 | $6.8M | 1.31% | +455K |
Quarterly Changes
New Positions
Increased Positions
Sector Breakdown
Healthcare0.0% ($3.506416672162942e+289T)
Unknown0.0% ($93757104651162959872.0T)
Technology0.0% ($15712143854200386.0T)
Financial Services0.0% ($8535409.6T)
Energy0.0% ($59.8B)
Industrials0.0% ($30.8B)
Filing History
Fund Information
SPHERA FUNDS MANAGEMENT LTD. is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $517.3M across 98 holdings. The largest position is TEVA PHARMACEUTICAL INDS LTD (TEVA), representing 6.8% of the portfolio. Compared to the previous quarter, the fund opened 30 new positions and closed 37 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.