Siren, L.L.C. Q4 2024 Filing
Filed February 14, 2025
Portfolio Value
$2.3T
Holdings
117
Report Date
Q4 2024
Filing Type
13F-HR
All Holdings (117 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | SRRKScholar Rock Holding Corp | 9,250,005 | $399.8B | 17.66% | |
| 2 | ONCBeigene Ltd | 653,721 | $120.7B | 5.33% | |
| 3 | KYMRKymera Therapeutics Inc | 2,969,733 | $119.5B | 5.28% | |
| 4 | APLSApellis Pharmaceuticals Inc | 2,816,258 | $89.9B | 3.97% | |
| 5 | CRNXCrinetics Pharmaceuticals Inc | 1,609,652 | $82.3B | 3.64% | |
| 6 | ARGXargenx SE | 115,045 | $70.8B | 3.13% | |
| 7 | BCAXBicara Therapeutics Inc | 3,272,827 | $57.0B | 2.52% | |
| 8 | ARWRArrowhead Pharmaceuticals Inc | 2,901,681 | $54.6B | 2.41% | |
| 9 | NAMSNewAmsterdam Pharma Company NV | 2,095,638 | $53.9B | 2.38% | |
| 10 | SEPNSepterna Inc | 2,202,514 | $50.4B | 2.23% | |
| 11 | CNTACentessa Pharmaceuticals PLC | 3,004,677 | $50.3B | 2.22% | |
| 12 | SWTXSpringWorks Therapeutics Inc | 1,377,701 | $49.8B | 2.20% | |
| 13 | NMRANeumora Therapeutics Inc | 4,396,100 | $46.6B | 2.06% | |
| 14 | WVEWAVE Life Sciences Ltd | 3,750,491 | $46.4B | 2.05% | |
| 15 | ASNDAscendis Pharma A/S | 297,321 | $40.9B | 1.81% | |
| 16 | MDGLMadrigal Pharmaceuticals Inc | 125,942 | $38.9B | 1.72% | |
| 17 | TBLATaboola.com Ltd | 9,969,495 | $36.4B | 1.61% | |
| 18 | APGEApogee Therapeutics Inc | 747,325 | $33.9B | 1.50% | |
| 19 | MRUSMerus NV | 784,412 | $33.0B | 1.46% | |
| 20 | RNAAvidity Biosciences Inc | 1,127,295 | $32.8B | 1.45% | |
| 21 | VERAVera Therapeutics Inc | 758,465 | $32.1B | 1.42% | |
| 22 | DYNDyne Therapeutics Inc | 1,347,456 | $31.7B | 1.40% | |
| 23 | XENEXenon Pharmaceuticals Inc | 743,769 | $29.2B | 1.29% | |
| 24 | LXRXLexicon Pharmaceuticals Inc | 38,918,903 | $28.8B | 1.27% | |
| 25 | BCYCBicycle Therapeutics PLC | 1,839,398 | $25.8B | 1.14% | |
| 26 | RVMDRevolution Medicines Inc | 571,548 | $25.0B | 1.10% | |
| 27 | PCVXVaxcyte Inc | 299,991 | $24.6B | 1.08% | |
| 28 | RCUSArcus Biosciences Inc | 1,612,077 | $24.0B | 1.06% | |
| 29 | ERASErasca Inc | 8,857,179 | $22.2B | 0.98% | |
| 30 | STOKStoke Therapeutics Inc | 2,000,000 | $22.1B | 0.97% | |
| 31 | 1K0IGM Biosciences Inc | 3,330,422 | $20.3B | 0.90% | |
| 32 | EWTXEdgewise Therapeutics Inc | 734,343 | $19.6B | 0.87% | |
| 33 | SLNSilence Therapeutics PLC | 2,831,770 | $19.5B | 0.86% | |
| 34 | CYTKCytokinetics Inc | 402,323 | $18.9B | 0.84% | |
| 35 | DNLIDenali Therapeutics Inc | 834,028 | $17.0B | 0.75% | |
| 36 | KRROKorro Bio Inc | 418,833 | $15.9B | 0.70% | |
| 37 | SLNOSoleno Therapeutics Inc | 351,818 | $15.8B | 0.70% | |
| 38 | PRTAProthena Corporation PLC | 1,099,840 | $15.2B | 0.67% | |
| 39 | SLDBSolid Biosciences Inc | 3,749,041 | $15.0B | 0.66% | |
| 40 | CGEMCullinan Therapeutics Inc | 1,211,357 | $14.8B | 0.65% | |
| 41 | UPBUpstream Bio Inc | 800,000 | $13.2B | 0.58% | |
| 42 | TRVITrevi Therapeutics Inc | 2,906,060 | $12.0B | 0.53% | |
| 43 | KURAKura Oncology Inc | 1,339,942 | $11.7B | 0.52% | |
| 44 | TSHATaysha Gene Therapies Inc | 6,602,475 | $11.4B | 0.50% | |
| 45 | RELYRemitly Global Inc | 490,449 | $11.1B | 0.49% | |
| 46 | RNACCartesian Therapeutics Inc | 572,236 | $10.2B | 0.45% | |
| 47 | MSFTMicrosoft Corp | 23,000 | $9.7B | 0.43% | |
| 48 | JANXJanux Therapeutics Inc | 175,000 | $9.4B | 0.41% | |
| 49 | SEERSeer Inc | 4,000,000 | $9.2B | 0.41% | |
| 50 | ISIIonis Pharmaceuticals Inc | 250,000 | $8.7B | 0.39% | |
| 51 | SYRESpyre Therapeutics Inc | 374,000 | $8.7B | 0.38% | |
| 52 | CRWDCrowdStrike Holdings Inc | 24,000 | $8.2B | 0.36% | |
| 53 | IOVAIovance Biotherapeutics Inc | 1,106,040 | $8.2B | 0.36% | |
| 54 | ORICOric Pharmaceuticals Inc | 1,007,575 | $8.1B | 0.36% | |
| 55 | TNGXTango Therapeutics Inc | 2,603,897 | $8.0B | 0.36% | |
| 56 | AMZNAmazon.com Inc | 36,500 | $8.0B | 0.35% | |
| 57 | RCKTRocket Pharmaceuticals Inc | 600,000 | $7.5B | 0.33% | |
| 58 | IONQIONQ Inc | 170,000 | $7.1B | 0.31% | |
| 59 | IHSIHS Holding Limited | 2,357,520 | $6.9B | 0.30% | |
| 60 | RAPPRapport Therapeutics Inc | 384,197 | $6.8B | 0.30% | |
| 61 | NVDANVIDIA Corp | 48,932 | $6.6B | 0.29% | |
| 62 | NOWServiceNow Inc | 5,605 | $5.9B | 0.26% | |
| 63 | SLRNACELYRIN Inc | 1,729,665 | $5.4B | 0.24% | |
| 64 | PDDPDD Holdings Inc | 52,901 | $5.1B | 0.23% | |
| 65 | GOSSGossamer Bio Inc | 5,415,968 | $4.9B | 0.22% | Call |
| 66 | DTDynatrace Inc | 82,729 | $4.5B | 0.20% | |
| 67 | BABoeing Co | 25,000 | $4.4B | 0.20% | |
| 68 | N1UANew Oriental Education & Technology Group Inc | 68,500 | $4.4B | 0.19% | |
| 69 | DDOGDatadog Inc | 30,425 | $4.3B | 0.19% | |
| 70 | PRQRProQR Therapeutics NV | 1,575,000 | $4.2B | 0.18% | |
| 71 | LXEOLexeo Therapeutics Inc | 603,435 | $4.0B | 0.18% | |
| 72 | ADBEAdobe Inc | 8,798 | $3.9B | 0.17% | |
| 73 | PHATPhathom Pharmaceuticals Inc | 460,753 | $3.7B | 0.17% | |
| 74 | TILInstil Bio Inc | 192,433 | $3.7B | 0.16% | |
| 75 | FROGJfrog Ltd | 120,116 | $3.5B | 0.16% | |
| 76 | FHTXFoghorn Therapeutics Inc. | 720,720 | $3.4B | 0.15% | |
| 77 | VIGLVigil Neuroscience Inc | 1,991,038 | $3.4B | 0.15% | |
| 78 | NBISNebius Group NV | 120,000 | $3.3B | 0.15% | |
| 79 | SGMTSagimet Biosciences Inc | 724,771 | $3.3B | 0.14% | |
| 80 | GBIOGBXGeneration Bio Co | 2,982,733 | $3.2B | 0.14% | |
| 81 | TSMTaiwan Semiconductor Manufacturing Co Ltd | 15,000 | $3.0B | 0.13% | |
| 82 | FCXFreeport-McMoRan Inc | 75,000 | $2.9B | 0.13% | |
| 83 | —Allovir Inc | 6,597,167 | $2.8B | 0.12% | |
| 84 | OVIDOvid Therapeutics Inc | 2,850,000 | $2.7B | 0.12% | |
| 85 | SESea Ltd | 25,000 | $2.7B | 0.12% | |
| 86 | ESTCElastic NV | 25,000 | $2.5B | 0.11% | |
| 87 | QCOMQualcomm Inc | 15,000 | $2.3B | 0.10% | |
| 88 | BIOABIOAGE Labs Inc | 388,000 | $2.2B | 0.10% | |
| 89 | BDTXBlack Diamond Therapeutics Inc | 1,046,517 | $2.2B | 0.10% | |
| 90 | RGNXRegenxbio Inc | 284,000 | $2.2B | 0.10% | |
| 91 | TRMLTourmaline Bio Inc | 91,426 | $1.9B | 0.08% | |
| 92 | PCORProcore Technologies Inc | 20,000 | $1.5B | 0.07% | |
| 93 | APLTApplied Therapeutics Inc | 1,633,768 | $1.4B | 0.06% | |
| 94 | GOOGLAlphabet Inc | 7,000 | $1.3B | 0.06% | |
| 95 | PYPLPayPal Holdings Inc | 15,000 | $1.3B | 0.06% | |
| 96 | HOOKHOOKIPA Pharma Inc | 566,640 | $1.1B | 0.05% | |
| 97 | HCAHCA Healthcare Inc | 3,750 | $1.1B | 0.05% | |
| 98 | BEKEKe Holdings Inc | 60,000 | $1.1B | 0.05% | |
| 99 | WKWorkiva Inc | 10,000 | $1.1B | 0.05% | |
| 100 | PANWPalo Alto Networks Inc | 6,000 | $1.1B | 0.05% |
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