EcoR1 Capital, LLC
CIK: 0001587114Latest portfolio: $2.2B · Q4 2025
Holdings
28
Total Value
$2.2B
New Positions
9
Closed Positions
11
Top Holdings
View All 28 Holdings →| # | Stock | Shares | Value | % Portfolio | Change | Type |
|---|---|---|---|---|---|---|
| 1 | ZYMEZYMEWORKS INC | 22,970,388 | $604.8M | 27.44% | — | |
| 2 | ANABANAPTYSBIO INC | 7,880,094 | $382.0M | 17.33% | — | |
| 3 | JAZZJAZZ PHARMACEUTICALS PLC | 1,706,469 | $290.1M | 13.16% | — | |
| 4 | CRNXCRINETICS PHARMACEUTICALS IN | 4,288,120 | $199.6M | 9.06% | — | |
| 5 | CNTACENTESSA PHARMACEUTICALS PLC | 3,115,000 | $77.9M | 3.53% | +2.6M | |
| 6 | CRSPCRISPR THERAPEUTICS AG | 1,389,276 | $72.9M | 3.31% | — | |
| 7 | MBXMBX BIOSCIENCES INC | 2,123,604 | $67.0M | 3.04% | — | |
| 8 | IMNMIMMUNOME INC | 2,855,590 | $61.3M | 2.78% | -1,223,825 | |
| 9 | ORICORIC PHARMACEUTICALS INC | 6,728,116 | $55.0M | 2.50% | — | |
| 10 | GLPGGALAPAGOS NV | 1,667,119 | $54.5M | 2.47% | — | |
| 11 | XNCRXENCOR INC | 3,318,612 | $50.8M | 2.31% | NEW | Call |
| 12 | CGONCG ONCOLOGY INC | 1,064,800 | $44.2M | 2.01% | NEW | Call |
| 13 | BBOTBRIDGEBIO ONCOLOGY THERAPEUT | 2,823,126 | $35.3M | 1.60% | — | |
| 14 | ETONETON PHARMACEUTICALS INC | 2,030,544 | $34.3M | 1.56% | — | |
| 15 | ZBIOZENAS BIOPHARMA INC | 789,500 | $28.7M | 1.30% | NEW | |
| 16 | NGNENEUROGENE INC | 1,271,342 | $26.2M | 1.19% | — | |
| 17 | GPCRSTRUCTURE THERAPEUTICS INC | 334,380 | $23.3M | 1.06% | NEW | |
| 18 | PCVXVAXCYTE INC | 450,000 | $20.8M | 0.94% | NEW | |
| 19 | AQSTAQUESTIVE THERAPEUTICS INC | 2,625,000 | $17.0M | 0.77% | — | |
| 20 | VYGRVOYAGER THERAPEUTICS INC | 4,002,847 | $15.7M | 0.71% | +3.3M | |
| 21 | ATRAATARA BIOTHERAPEUTICS INC | 573,183 | $10.4M | 0.47% | — | |
| 22 | MNKDMANNKIND CORP | 1,660,000 | $9.4M | 0.43% | NEW | |
| 23 | NUVB/WSNUVATION BIO INC | 963,333 | $8.6M | 0.39% | — | |
| 24 | EOLSEVOLUS INC | 675,000 | $4.5M | 0.20% | NEW | |
| 25 | IBIOIBIO INC | 2,228,000 | $4.3M | 0.20% | NEW |
Quarterly Changes
New Positions
Sector Breakdown
Healthcare0.0% ($6.048103820262901e+122T)
Unknown0.0% ($8.6M)
Filing History
| Quarter | Filing Date | Portfolio Value | Holdings |
|---|---|---|---|
| Q4 2025 | Feb 17, 2026 | $2.2B | 30 |
| Q3 2025 | Nov 14, 2025 | $2.1T | 30 |
| Q2 2025 | Aug 14, 2025 | $1.7T | 37 |
| Q1 2025 | May 15, 2025 | $1.7T | 46 |
| Q4 2024 | Feb 14, 2025 | $2.6T | 59 |
| Q3 2024 | Nov 14, 2024 | $2921.6T | 64 |
| Q2 2024 | Aug 14, 2024 | $3268.9T | 55 |
| Q1 2024 | May 15, 2024 | $3953.7T | 59 |
| Q4 2023 | Feb 14, 2024 | $3851.5T | 51 |
| Q3 2023 | Nov 14, 2023 | $2964.7T | 51 |
| Q2 2023 | Aug 14, 2023 | $4081.5T | 53 |
| Q1 2023 | May 15, 2023 | $3105.4T | 58 |
| Q4 2022 | Feb 14, 2023 | $3285.6T | 66 |
| Q3 2022 | Nov 14, 2022 | $3.4T | 76 |
| Q2 2022 | Aug 15, 2022 | $2.9T | 80 |
| Q1 2022 | May 16, 2022 | $3.2T | 87 |
| Q4 2021 | Feb 14, 2022 | $3.1T | 76 |
| Q3 2021 | Nov 15, 2021 | $2.9T | 71 |
| Q2 2021 | Aug 16, 2021 | $2.7T | 72 |
| Q1 2021 | May 17, 2021 | $2.3T | 71 |
| Q4 2020 | Feb 16, 2021 | $1.9T | 67 |
| Q3 2020 | Nov 16, 2020 | $1.4T | 50 |
| Q2 2020 | Aug 14, 2020 | $1.4T | 49 |
| Q1 2020 | May 15, 2020 | $957.2B | 51 |
| Q4 2019 | Feb 14, 2020 | $1.1T | 44 |
| Q3 2019 | Nov 14, 2019 | $791.9B | 41 |
| Q2 2019 | Aug 14, 2019 | $989.6B | 40 |
| Q1 2019 | May 15, 2019 | $1.1T | 41 |
| Q4 2018 | Feb 14, 2019 | $999.4B | 54 |
| Q3 2018 | Nov 14, 2018 | $1.1T | 51 |
| Q2 2018 | Aug 14, 2018 | $1.1T | 35 |
| Q1 2018 | May 15, 2018 | $997.0B | 32 |
| Q4 2017 | Feb 14, 2018 | $888.1B | 31 |
| Q3 2017 | Nov 14, 2017 | $750.3B | 40 |
| Q2 2017 | Aug 14, 2017 | $563.2B | 36 |
| Q1 2017 | May 15, 2017 | $395.6B | 33 |
| Q4 2016 | Feb 14, 2017 | $299.2B | 30 |
| Q3 2016 | Nov 14, 2016 | $325.9B | 31 |
| Q2 2016 | Aug 15, 2016 | $253.6B | 32 |
| Q1 2016 | May 16, 2016 | $286.2B | 37 |
Fund Information
EcoR1 Capital, LLC is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $2.2B across 28 holdings. The largest position is ZYMEWORKS INC (ZYME), representing 27.4% of the portfolio. Compared to the previous quarter, the fund opened 10 new positions and closed 12 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.