Sio Capital Management, LLC Q3 2025 Filing
Filed November 13, 2025
Portfolio Value
$395.2B
Holdings
51
Report Date
Q3 2025
Filing Type
13F-HR
All Holdings (51 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | MMSMAXIMUS INC | 557,615 | $50.9B | 12.89% | |
| 2 | CELCCELCUITY INC | 786,526 | $38.9B | 9.83% | |
| 3 | SNYSANOFI SA | 562,703 | $26.6B | 6.72% | |
| 4 | DNTHDIANTHUS THERAPEUTICS INC | 577,750 | $22.7B | 5.75% | |
| 5 | ALKSALKERMES PLC | 674,840 | $20.2B | 5.12% | |
| 6 | IRONDISC MEDICINE INC | 284,787 | $18.8B | 4.76% | |
| 7 | MRKMERCK & CO INC | 177,300 | $14.9B | 3.77% | |
| 8 | HSICHENRY SCHEIN INC | 219,207 | $14.5B | 3.68% | |
| 9 | CNCCENTENE CORP DEL | 387,600 | $13.8B | 3.50% | |
| 10 | KVUEKENVUE INC | 844,000 | $13.7B | 3.47% | |
| 11 | BMRNBIOMARIN PHARMACEUTICAL INC | 225,114 | $12.2B | 3.09% | |
| 12 | GSKGSK PLC | 268,873 | $11.6B | 2.94% | |
| 13 | DRUGBRIGHT MINDS BIOSCIENCES INC | 190,764 | $11.6B | 2.93% | |
| 14 | HAEHAEMONETICS CORP MASS | 198,035 | $9.7B | 2.44% | |
| 15 | AQSTAQUESTIVE THERAPEUTICS INC | 1,498,095 | $8.4B | 2.12% | |
| 16 | KALVKALVISTA PHARMACEUTICALS INC | 683,819 | $8.3B | 2.11% | |
| 17 | AVRANTERIS TECHNOLOGIES GLOBAL | 1,772,601 | $8.0B | 2.02% | |
| 18 | CRNXCRINETICS PHARMACEUTICALS IN | 174,841 | $7.3B | 1.84% | |
| 19 | TYRATYRA BIOSCIENCES INC | 514,947 | $7.2B | 1.82% | |
| 20 | RAPPRAPPORT THERAPEUTICS INC | 185,265 | $5.5B | 1.39% | |
| 21 | NVCRNOVOCURE LTD | 413,829 | $5.3B | 1.35% | |
| 22 | BSFAANI PHARMACEUTICALS INC | 55,723 | $5.1B | 1.29% | |
| 23 | EWTXEDGEWISE THERAPEUTICS INC | 307,181 | $5.0B | 1.26% | |
| 24 | TFXTELEFLEX INCORPORATED | 40,057 | $4.9B | 1.24% | |
| 25 | SLPSIMULATIONS PLUS INC | 320,307 | $4.8B | 1.22% | |
| 26 | PRQRPROQR THERAPEUTICS N V | 2,075,139 | $4.4B | 1.12% | |
| 27 | SISHOULDER INNOVATIONS INC | 350,000 | $4.4B | 1.11% | |
| 28 | PMVPPMV PHARMACEUTICALS INC | 2,636,548 | $3.7B | 0.93% | |
| 29 | SEPNSEPTERNA INC | 189,199 | $3.6B | 0.90% | |
| 30 | IDYAIDEAYA BIOSCIENCES INC | 124,230 | $3.4B | 0.86% | |
| 31 | ALGSALIGOS THERAPEUTICS INC | 335,937 | $3.3B | 0.83% | |
| 32 | ERASERASCA INC | 1,369,748 | $3.0B | 0.76% | |
| 33 | VIRVIR BIOTECHNOLOGY INC | 478,343 | $2.7B | 0.69% | |
| 34 | YB4PSAVARA INC | 726,851 | $2.6B | 0.66% | |
| 35 | VTYXVENTYX BIOSCIENCES INC | 829,178 | $2.6B | 0.65% | |
| 36 | NMTCNEUROONE MED TECHNOLOGIES CO | 2,360,635 | $2.1B | 0.53% | |
| 37 | OVIDOVID THERAPEUTICS INC | 1,427,495 | $1.9B | 0.47% | |
| 38 | BBOTBRIDGEBIO ONCOLOGY THERAPEUT | 130,628 | $1.5B | 0.38% | |
| 39 | CNTXCONTEXT THERAPEUTICS INC | 1,341,636 | $1.3B | 0.33% | |
| 40 | SENS1GBPSENSEONICS HOLDINGS INC | 2,315,749 | $1.0B | 0.26% | |
| 41 | TELATELA BIO INC | 636,300 | $948.1M | 0.24% | |
| 42 | AVTXAVALO THERAPEUTICS INC | 72,173 | $917.3M | 0.23% | |
| 43 | FHTXFOGHORN THERAPEUTICS INC | 122,889 | $600.9M | 0.15% | |
| 44 | MODDMODULAR MED INC | 785,824 | $549.9M | 0.14% | |
| 45 | NYXHNYXOAH S A | 50,839 | $233.9M | 0.06% | |
| 46 | BOLDBOUNDLESS BIO INC | 163,679 | $201.3M | 0.05% | |
| 47 | APREAPREA THERAPEUTICS INC | 112,223 | $165.5M | 0.04% | |
| 48 | TERNTERNS PHARMACEUTICALS INC | 10,100 | $75.9M | 0.02% | |
| 49 | NXTCNEXTCURE INC | 10,940 | $64.1M | 0.02% | |
| 50 | RCKTWROCKET PHARMACEUTICALS INC | 400,000 | $14.4M | 0.00% | |
| 51 | HUMAWHUMACYTE INC | 49,998 | $12.2M | 0.00% |